Reactive Proliferation Of White Cells And Lymph Nodes

Question 1

Leukocytosis means an increase in number of WBCs. What factors influence the peripheral blood leukocyte count?

Answer 1

1. Size of myeloid and lymphoid precursors
2. Storage pool
3. Marginal pool
4. Rate of extravasation of cells from blood to tissues

Question 2

Major cause of neutrophilic leukocytosis is __________

Answer 2

Infection

Question 3

What cytokines are involved in neutrophilia in acute infection?

Answer 3

TNF AND IL1

Question 4

What is the role of IL1 and TNF in prolonged infection?

Answer 4

They stimulate macrophages and other cells to make hematopoietic growth factors to increase the number of WBCs

Question 5

IL5 stimulate the production of ____________

Answer 5

Eosinophils

Question 6

G-CSF causes ____________

Answer 6

Neutrophilia

Question 7

In severe inflammatory diseases, there is neutrophilic leukocytosis with special features. What are the cytoplasmic features?

Answer 7

Toxic granules
Döhle bodies
Cytoplasmic vacuoles

Question 8

How can we distinguish toxic granules from the normal granules in neutrophils?

Answer 8

Toxic granules are coarser and darker than normal granules. They are azurophilic

Question 9

What are Döhle bodies?

Answer 9

Dilated endoplasmic reticulum with sky blue appearance

Question 10

Sometimes in acute viral infections, the leukocytosis can resemble ____________

Answer 10

Neoplastic condition