Arbovirus Flashcards
Dengue virus is a _________ (phlebovirus/flavivirus)
flavivirus
Classic dengue fever is also called __________ fever
breakbone fever
Classic dengue fever begins suddenly with influenza-like syndromes consisting of fever, malaise, headache, and _________ (abdominal/retro-orbital) pain
retro-orbital pain
Dengue virus is transmitted from _________ to humans by mosquitoes
monkeys
Humans and monkeys are the ___________ (definitive/reservoir) host
reservoir
Antibodies (called ”enhancing” antibodies) to one serotype __________ (increase/decrease) the efficiency of infection by another serotype, resulting in more serious disease. {DENGUE VIRUS}
increase
Enlarged __________ (liver/spleen/lymph nodes), facial flushing, a maculopapular rash and leukopenia are common in dengue fever.
lymph nodes
Dengue hemorrhagic fever is more severe, with a fatality rate of ____% in which shock occurs and hemorrhage develops in GIT and skin.
10%
Dengue hemorrhagic fever is more common in ____________ whereas the classic form is found in tropical areas worldwide.
Southern Asia
Hemorrhagic shock syndrome occurs the _________ (first/second) time infection occurs.
second
Hemorrhagic shock syndrome is due to the production of large amounts of ____________ at the time of second dengue infection.
cross-reacting antibodies
A patient gets infected with one serotype of dengue and he recovers (he produces antibodies). Then he gets infected with another serotype of dengue and he makes antibodies to the first serotype leading to ____________ activation.
complement activation
The complement activation leads to _________ (increased/decreased) vascular permeability and thrombocytopenia when second dengue infection occurs.
increased
How does shock occurs in dengue?
The viral-antibody complex gets into the monocyte or macrophage —> leading to the liberation of cytokines that produce shock or hemorrhage.
Dengue virus is transmitted by the Aedes ________ (anopheles/aegypti) mosquito.
aegypti
