Non Hodgkin Lymphoma Flashcards
1
Q
Median age at dx of SLL/CLL is _____ years
A
60
2
Q
________ is commonly associated with immune function abnormalities like hemolytic anemia
A
SLL/CLL
3
Q
IHC of SLL/CLL?
A
CD5+
CD19+
CD20+
CD23+
4
Q
Transformation of SLL/CLL into diffuse B cell lymphoma is called __________
A
Ritcher syndrome
5
Q
Origin of B cells in SLL/CLL is ___________ or ___________
A
naive B cell
postgerminal center memory B cell
6
Q
What is more common, CLL or SLL?
A
CLL is more common
7
Q
What are the features of SLL?
A
Lymph node has small lymphocytes along with large activated lymphocytes
8
Q
What is the characteristic features of CLL?
A
On peripheral blood smear, there is lymphocytosis along with smudge cells
9
Q
What are the genetic mutations in SLL/CLL?
A
Trisomy 12q
Deletion of 11q, 13q, 17p
10
Q
What is the presentation of SLL/CLL?
A
Fatigue, anorexia, weight loss Autoimmune hemolytic anemia Thrombocytopenia (bleeding tendency) Hypogammaglobulinemia (infections) Generalized lymphadenopathy Hepatosplenomegaly
