RBC Morphology Flashcards
1
Q
Erythropoiesis
A
Production of RBCs
2
Q
Erythropoiesis
Where is Happens
A
Occurs in the bone marrow with aid of erythropoietin
* stored in kidneys
3
Q
Erythropoiesis
Cellular Changes
A
- Cytoplasm size decreases
- Nucleus size decreases
- Chromatin clumps
- Basophilic –> Eosinophilic
4
Q
RBC Cell Stages
(5)
A
- Rubriblast
- Prorubricyte
- Rubricyte
- Metarubricyte
- Reticulocyte
5
Q
Reticulocyte
A
- Cytoplasm stains bluish-buff (ribosomes)
- No central pallor
- Only 50% will carry oxygen
6
Q
Cat RBC
A
- 90 day lifespan
- Round shape
- Little to no central pallor
- Smaller than dogs
7
Q
Dog RBC
A
- 100-110 day lifespan
- Biconcave shape (discocyte)
- Larger than cats
8
Q
Anisocytosis
A
- Abnormal variation in RBC size
- Slight, Moderate, or Marked
9
Q
Polychromasia
A
- Variation in cell colors
- Immature RBC stains blue
10
Q
Howell-Jolly Bodies
A
- Nuclear remnant material inside RBC
- Sign of regeneration
- If no reticulocytes seen - sign of macrophage dysfunction (spleen supposed to filter out)
11
Q
A
Howell-Jolly Bodies
12
Q
Nucleated RBC
A
- Counted as WBC on cell counter
- May be seen in regeneration, CHF, IMHA, lead poisoning, hemangiosarcoma, liver disease
13
Q
Poikilocytosis
A
- Abnormally shaped RBCs
- Exact shape should be used for specific diseases
- Don’t report on lab forms
14
Q
Leptocytes
A
- Large cells with thin membrane and fold easily
- Target cells - codocytes
- Barr cells - knizocytes
- Sign of liver disease
- Report as either target or barr cells
15
Q
A
Barr Cell - Knizocytes
17
Q
A
Acanthocytes
19
Q
A
Spherocytes
21
Q
A
Heinz Bodies
23
Q
A
Echinocytes
25
Q
A
Schistocytes
31
Q
A
Keratocyte
33
Q
A
Eccentrocyte
