RBC and Bleeding, Lung and Pleura, Head and Neck Flashcards
1
Q
Differentials for microcytic anemia (MCV <80 fL)
A
TAILS
*Thalassemia
*Anemia of chronic inflammation
*Iron deficiency anemia
*Lead poisoning
*Sideroblastic anemia
2
Q
Splenomegaly in the case of hemolytic anemia can be seen in what type of hemolysis?
A
*Extravascular hemolysis
*Chronic hemolysis
For intravascular and acute, usually hemoglobinemia, hemoglobinuria, hemosiderinuria due to hemoglobin being liberated inside the blood vessel (soon be cleared by kidney)
3
Q
Defect in hereditary spherocytosis
A
Intrinsic - defect in membrane skeleton (spectrin, ankyrin, Band 3, Band 4.2) making them less deformable and easily lysed in spleen due to entrapment there
4
Q
Etiology of G6PD
A
Intrinsic - G6PD deficiency –> ↓ NADPH –> ↓ reduced glutathione –> ↑ RBC susceptibility to oxidative stress
Triggers: infections, drugs, foods
5
Q
Cell findings in G6PD
A
Heinz bodies (precipitated denatured Hb) - asplenic
Bite cells - intact spleen
Spherocytes
6
Q
Etiology of Sickle cell disease
A
Autosomal recessive (SA is asymptomatic, SS is symptomatic)
Intrinsic: 6th codon of B-globin chain has point mutation (glutamate –> valine) –> hemoglobin S (HbS)
7
Q
Situations favoring sickling of RBCs in Sickle cell disease
A
↓ intracellular pH
↓ O2 tension
8
Q
Lab findings in Sickle Cell Anemia
A
Microcytic anemia
Target cell
Sickle cell
↓ HbA
↑ HbS
9
Q
Thalassemia general etiology and pathogenesis
A
Etiology
↓ Globin chains –> ↓ Hb synthesis –> anemia
Pathogenesis
↓ in one globin chain –> excess of other globin chain –>precipitate inclusions –> membrane damage –> apoptosis within marrow –> anemia
10
Q
Thalassemia morphology and lab:
CBC:
PBS:
Skull X-ray:
Others:
A
CBC: Microcytic hypochromic
PBS:Poikilocytosis, anisocytosis, Target cells
Skull xray: Crew cut appearance
Secondary hemochromatosis (liver, pancreas, heart)
11
Q
Etiology:
Beta Thalassemia
Alpha Thalassemia
A
Beta thalassemia:
B-globin mutations (2 copies in Chromosome 11)
Alpha thalassemia:
A-globin gene deletions (4 copies in Chromosome 16)
12
Q
Beta thalassemia that is transfusion dependent
A
Beta thalassemia major (2 mutated)
*Beta thalassemia intermedia (variable mutated), transfusion in special situations
*Beta thalassemia minor (1 mutated), asymptomatic or mild
13
Q
Alpha thalassemia trait, how many alpha globin gene deletions
A
2
14
Q
HbH, how many alpha globin gene deletions
A
3
(B4)
15
Q
Hydrops fetalis, how many alpha globin gene deletions
A
4
(γ4)
16
Q
When does anemia occur in those with Beta thalassemia? How about Alpha thalassemia
A
Beta thalassemia: 6-9 months after birth (shift from HbF –> HbA)
Alpha thalassemia: At birth (need of alpha globin chains even for HbF)
17
Q
Why is Alpha thalassemia less severe than Beta thalassemia?
A
Because it only misses B-globin chains (and γ-globin chains) which are more soluble than a chains –> lesser inclusions –> ↓ membrane damage –> ↓ apoptosis in marrow –> less severe anemia
18
Q
Defect in Paroxysmal Nocturnal Hemoglobinuria
A
PIGA mutations –> ↓ GPI anchor –> ↓ CD55, CD59, C8 binding protein –> ↑ susceptibility to complement mediated lysis
19
Q
Antibody in Warm-Antibody Type Autoimmune Hemolytic Anemia
A
IgG active at 37C
*Associated with SLE, drugs, CLL
20
Q
Antibody in Cold Agglutinin Disease
A
IgM active at <37C
*Associated with infections of Mycoplasma pneumoniae, CMV, EBV, HIV, and CLL
21
Q
Antibody in Paroxysmal Cold Hemoglobinuria
A
IgG Anti P (Donath-Landsteiner antibody)
22
Q
Coomb’s test that detects antibodies present in patient’s serum
A
Indirect Coombs’ Test
Used for compatibility testing, bloodbank etc.
*Direct Coombs’ Test detects antibodies attached to RBCs
ex: Hemolytic disease of fetus and newborn
23
Q
Type of hemolysis in Cell finding in Hemolytic Anemia 2ndary to red cell trauma
A
Intravascular due to sheer stress
24
Q
Cell finding in Hemolytic Anemia 2ndary to red cell trauma
A
Schistocytes (fragmented red cell)
Echinocytes (Burr cell)
25
General pathogenesis of megaloblastic anemia
Impaired DNA synthesis --> ineffective hematopoiesis --> premature death of precursor cells --> Peripheral blood cytopenias
*Morphology: Hypercellular marrow with megaloblastoid changes
26
Chem finding in Vitamin B12 deficiency (Pernicious anemia)
↑ Homocysteine
↑ Methylmalonate
27
Between Vitamin B12 deficiency and Vitamin B9 deficiency, __________________ has neurologic symptoms
Vitamin B12 deficiency
28
Chem finding in Vitamin B9 deficiency
↑ Homocysteine
NORMAL Methylmalonate
29
Iron studies: IDA
↓ Fe
↑ TIBC
↓ Ferritin
30
Iron studies: Anemia of Chronic Inflammation
↓ Fe
↓ TIBC
↑ Ferritin
31
Normal values
MCV
MCH
MCHC
MCV: 80-100
MCH: 26-32
MCHC: 32-36
32
Variability in red cell size
Anisocytosis
33
Variability in red cell shape
Poikilocytosis
34
Etiology and pathogenesis of Thrombotic Thrombocytopenic Purpura (ITP)
Deficient ADAMTS13 —> inc vWF polymers —> inc platelet activation —> inc thrombosis —> microangiopathic hemolytic anemia
35
Clinical features of TTP
FATRN
Fever
Microangiopathic hemolytic anemia
Thrombocytopenia
Renal failure
Neurologic deficits
36
Etiology of ITP
Anti GpIIB/IIIA and Gp1b/IX IgG
37
HUS pathogenesis
Typical: E. Coli O157:H7 (Shiga-like toxin)
Atypical: complement activation inhibitors deficiency
*thrombocytopenia, anemia, renal failure
*Normal ADAMTS13 levels
38
DISORDER OF PLT FXN: Autosomal recessive inherited GpIIB/IIIa deficiency (problem in plt aggregation)
*inc BT, N PC
Glanzmann Thrombastenia
39
DISORDER OF PLT FXN: Autosomal recessive inherited GPIB/IX deficiency (problem in plt adhesion)
*inc BT, dec PC
Bernard-Soulier Syndrome (BSS)/Giant Platelet Syndrome
40
Most common inherited bleeding disorder
Von Willebrand Disease
(Autosomal dominant)
vWF factor deficiency —> FVIII deficiency
*inc BT, inc aPTT, normal PT
41
Most common hereditary disease associated with life-threatening complications
Hemophilia
(X-linked recessive)
A: Factor VIII deficiency
B: Xmas dse; Factor IX deficiency
C: Factor XI deficiency
Normal BT and PT, inc aPTT
42
Treatmed for vWD
Desmopressin
Factor VIII replacement
43
Heyde syndrome triad
Aortic stenosis
GI bleeding
Acquired vWD
44
DIC + Giant Hemangiomas
Kasabach-Merritt syndrome
45
Bilateral adrenal hemorrhage in meningococcemia
Waterhouse-Friderichsen syndrome
46
Acute DIC manifestation
Bleeding
47
Chronic DIC manifestation
Thrombosis
48
Most common indication for lung transplantation
Idiopathic Pulmonary Fibrosis
49
Masson bodies
Cryptogenic Organizing Pneumonia
50
Particle size most dangerous for pneumoconiosis
1-5 um (smaller particles can reach distal airways)
51
Exposure to what element causes silicosis
Silica (Quartz)
*building
*road demolition
*stone carvers
*jewellers
52
Exposure to roof insulation predisposes to
Asbestos
53
Silicosis affects the ________ lobes of the lungs while asbestosis affects the __________ lobes of the lungs
Upper; lower
54
Laminated concretions seen in sarcoidosis
Schaumann bodies
55
Stellate inclusions seen in sarcoidosis
Asteroid bodies
56
Most common organs involved in sarcoidosis
Lymph nodes (hilar and mediastinal) > lung
57
A lung condition that can look like pneumonia but does not resolve with antibiotics
Acute hypersensitivity pneumonitis
58
Macrophages with dusty brown pigment seen in smoking-related interstitial diseases (Desquamative interstitial pneumonia and respiratory bronchiolitis associated interstitial lung disease)
Smoker's macrophages
59
WHO classification of pulmonary HTN secondary to autoimmune dse (BMPR2 mutations)
Group 1
60
WHO classification of pulmonary HTN secondary to unclear and multifactorial mechanisms
Group 5
61
Pulmonary hypertension has a mean pulmonary artery pressure of _________ mmHg at rest
>= 25 mmHg
62
Most common bacterial cause of acute exacerbations of COPD, otitis media and pink eye in children
Haemophilus influenzae
63
Bacterial cause of pneumonia in the elderly, and 2nd most common cause of acute exacerbations of COPD
Moraxella catarrhalis
64
Secondary bacterial pneumonia post-viral respiratory illnesses (measles and influenza)
Staphylococcus aureus
65
Most common cause of gram negative beacterial pneumonia, in chronic alcoholics, and with currant jelly like sputum
Klebsiella pneumoniae
66
Stage of lobar pneumonia
where the lungs are heavy
and boggy; Vascular
engorgement, intra-alveolar
fluid with few neutrophils,
numerous bacteria
Congestion
67
Stage of lobar pneumonia
where the lungs are red, firm,
airless with a liver-like
consistency. (+) intra alveolar
PMNs, RBCs, fibrin
Red hepatization
68
Stage of lobar pneumonia
where the lungs are grayish brown lobe, progressive RBC disintegration, with fibrinosuppurative exudate
Gray hepatization
69
Stage of lobar pneumonia
where exudate is broken down by enzymatic digestion into granular, semifluid debris
Resolution
70
Microscopic finding of the
lungs in bronchopneumonia
Neutrophilic rich exudate within airways
71
Most common symptoms of lung carcinoma
Cough > Wt loss > Chest pain > Dyspnea
72
Distant spread of lung carcinoma organs affected
ALBB
Adrenals
Liver
Brain
Bone
73
Most common mutations in nonsmokers with adenocarcinoma
EGFR
74
Adenocarcinoma mutation with worst prognosis
KRAS
75
IHC stain in lung adenocarcinoma
(+) TTF-1, Napsin A
76
Lung carcinomas that have a central site of predilection
Squamous cell carcinoma
Small cell carcinoma
Carcinoid/endocrine tumor
77
Lung carcinomas that have a peripheral site of predilection
Adenocarcinoma
Large cell carcinoma
Carcinoid/endocrine tumor
78
Mutations in Squamous cell carcinoma of lung
TP53, CDKN2A, FGFR-1
79
IHC stain in squamous cell carcinoma of lung
(+) p40, p63
80
Mutations in Small cell carcinoma of lung
(+) TP53, RB
81
Lung carcinomas with salt and pepper chromatin
Small cell carcinoma (inc mitosis)
Carcinoid/neuroendocrine tumor (dec mitosis)
82
Carcinoids arise from
Kulchitsky cells (neuroendocrine cells on basement membrane of bronchi/bronchioles)
83
A tumor that encases the lung
Diffuse pleural mesothelioma
84
>95% of adult hemoglobin is
composed of this type
HbA1/HbA (Adult
hemoglobin): α2β2
85
Type of hemolytic anemia
that occurs due to inherent
defects in red cells
Intrinsic hemolysis
86
Type of hemolysis that occurs
in the spleen
Extravascular hemolysis
87
Clinical features observed in
intravascular hemolysis
Hemoglobinemia,
Hemoglobinuria,
Hemosiderinuria
88
Viral infection associated
with aplastic crisis
Parvovirus B19 infection
89
Most likely diagnosis in a
patient presenting with
jaundice and gallstones; Lab
findings include ↑ MCHC, ↑
RBC osmotic fragility
Hereditary Spherocytosis
90
Most common trigger of red
cell hemolysis in G6PD
deficiency
Infection
91
Precipitated denatured
hemoglobin seen in G6PD
deficiency
Heinz bodies
92
Having G6PD deficiency
and/or sickle cell trait is
protective against which
parasitic infection
Malaria
93
Pattern of inheritance of
sickle cell anemia
Autosomal recessive
94
Etiology of sickle cell anemia
Point mutation in the β-
globin gene (glu→val)
95
Most common cause of
morbidity and mortality in
sickle cell anemia
Vaso-occlusive (Pain)
crises
96
Autosplenectomy causes
increased susceptibility to
which type of organisms
encapsulated organisms (S.
pneumoniae and H.
influenzae)
97
Beta-thalassemia syndrome
with 2 mutated β globin
genes in chromosome 11
β- thalassemia major
98
Alpha-thalassemia syndrome
with 3 deleted α-globin gene
mutations
HbH disease
99
Alpha-thalassemia syndrome
with 4 deleted α-globin gene
mutations
Hydrops fetalis
100
Red cell surface proteins
absent in patients with
paroxysmal nocturnal
hemoglobinuria which
increases susceptibility to
complement-mediated lysis
CD55, CD59
101
Most common cause of
disease-related death in PNH
Venous thrombosis
102
Most common form of
immunohemolytic anemia;
Associated with autoimmune
diseases (SLE), Lymphoid
neoplasms (CLL)
Warm Autoimmune
Hemolytic Anemia
(WAIHA)
103
Type of antibody in WAIHA
IgG active at 37°C
104
Infections associated with
cold agglutinin disease
Mycoplasma pneumoniae,
EBV, CMV, HIV
105
Type of antibody in CAD
IgM active below 37°C
106
Disease-causing antibody in
paroxysmal cold
hemoglobinuria, which is
common in children postviral
infection
IgG anti-P (Donath-
Landsteiner antibody)
107
Possible deficient vitamins in
patients with megaloblastic
anemia
Vitamin B12, B9
108
Gastrectomy and
autoimmune atrophic
gastritis causes vitamin B12
deficiency due to the absence
of
Intrinsic factor
109
Parasite that competes with
vitamin B12 absorption
Diphyllobothrium latum
110
Features that differentiate
Vitamin B12 deficiency from
Vitamin B9 deficiency
(+) neurologic symptoms
due to subacute combined
degeneration of spinal cord
+ ↑ methylmalonate
(normal in Vit B9
deficiency)
111
DMARD used in the
management of RA that
causes Vitamin B9 deficiency
Methotrexate (a folate
antagonist)
112
Most common nutritional
disorder in the world
Iron deficiency anemia
113
Peptide hormone increased
in anemia of chronic disease
that prevents mobilization of
stored iron
Hepcidin
114
BMA: Hypocellular marrow
with fat cells and scattered
lymphocytes and plasma
cells; CBC:Pancytopenia with
normocytic, normochromic
anemia
Aplastic anemia
115
Most common cause of
aplastic anemia
Drugs
116
(+) Parvovirus B19
infection/autoimmune
disease; BMA: Absent
erythroblasts with normal
granulocytic and
megakaryocytic lineages
Pure red cell aplasia
117
Space-occupying lesions
displace bone marrow
elements
Myelophthisic anemia
118
Most common cause of secondary
myelophthisic anemia
Metastasis
119
A 5-year-old patient presents
with multiple petechiae. He
had a URTI 3 days ago and
has no significant medical
history. CBC: Low platelets
Immune thrombocytopenic
purpura (ITP)
120
Etiology of immune
thrombocytopenic purpura
Anti-GPIIb-IIIa and GPIb-IX
(80%) IgG
121
Form of ITP that is more
common in adults and is
associated with SLE, HIV, CLL
Chronic ITP
122
Thrombotic disease that
occurs due to decreased
ADAMTS13 level or activity
Thrombotic
thrombocytopenic purpura
(TTP)
123
Action of ADAMTS12
Degrades von Willebrand
factor (vWF) multimers
124
Causative agent of typical
hemolytic uremic syndrome
E. coli O157:H7
125
Autosomal recessive
inherited GPIb/IX deficiency;
defective platelet adhesion
Bernard-Soulier Syndrome
/ Giant Platelet Syndrome
126
Autosomal recessive
inherited GPIIb/IIIa
deficiency; defective platelet
aggregation
Glanzmann
Thrombasthenia
127
Most common inherited
bleeding disorder
Von Willebrand Disease
128
Clinical and laboratory
features of VWD
Mucocutaneous>Internal
bleeding, ↑ BT, ↑ aPTT,
Normal PT
129
Most common hereditary
disease associated with lifethreatening
bleeding
Hemophilia
130
Christmas Disease
Hemophilia B (Factor IX
deficiency)
131
Most common adverse
transfusion reaction
Febrile non-hemolytic
anemia
132
Most common reaction in
platelet transfusions
Allergic reactions
133
Transfusion-transmitted
infections are more common
in this blood product due to
its storage at room
temperature
Platelet concentrate
134
Type of atelectasis due to
airway obstruction
Resorption atelectasis
135
Type of atelectasis associated
with fluid, air, or mass inside
the pleural cavity
Compression atelectasis
136
Type of atelectasis that occurs
as a result of
pulmonary/pleural fibrosis
Contraction atelectasis
137
Abrupt onset of hypoxemia
and bilateral pulmonary
edema in the absence of heart
failure
Acute lung injury
138
Histologic hallmark for the
acute phase of acute
respiratory distress
syndrome
Diffuse Alveolar Damage
139
Irreversible enlargement of
airspaces distal to terminal
bronchiole
Emphysema
140
Type of emphysema
associated with smoking
Centriacinar
141
Type of emphysema
associated with α-1-
antitrypsin deficiency
Panacinar
142
Type of emphysema
associated with spontaneous
pneumothorax in young
adults
Distal acinar (Paraseptal)
143
Persistent cough with sputum
production for at least 3
months in at least 2
consecutive years in the
absence of any other cause
Chronic bronchitis
144
Ratio of thickness of the
mucus gland layer to the wall
thickness
Reid index (N = 0.4)
145
Chronic inflammatory airway
disease that produces
episodic variable expiratory
airflow obstruction
Asthma
146
Extruded mucus plugs seen in
sputum examination of
asthmatic patients
Curschmann's spiral
147
Microscopic crystals made up
of galectin-10 from
eosinophils
Charcot-Leyden crystals
148
A known cystic fibrosis
patient presents with severe,
persistent cough with foulsmelling
mucopurulent
sputum. Episodes of
hemoptysis were also noted.
What is the most likely
diagnosis?
Bronchiectasis
149
Bronchiectasis, Sinusitis, Situs
inversus, Sperm dysmotility
Kartagener syndrome
150
Clinicopathologic syndrome
marked by progressive
interstitial pulmonary fibrosis
and respiratory failure; (+)
Honeycomb fibrosis
Idiopathic pulmonary
fibrosis (IPF)
151
Most important
environmental factor of IPF
Cigarette smoking
152
Black discoloration of the
bronchi due to carbon
deposits; accentuated in coal
workers’ pneumoconiosis
Anthracosis
153
Most common
pneumoconiosis and chronic
occupational disease
worldwide; (+) Eggshell
calcifications in lymph nodes
Silicosis
154
Hallmark of silicosis
Whorled collagen fibers
surrounded by dust-laden
macrophages
155
Most common manifestation
of asbestosis
Pleural plaques
156
Golden brown rods with
translucent core containing
asbestos coated with an ironprotein
complex
Asbestos bodies
157
X-ray finding in sarcoidosis
Bilateral hilar adenopathy
158
WHO classification of
pulmonary HTN secondary to
thromboembolism
Group 4
159
Most common cause of
community- acquired acute
pneumonia and lobar
pneumonia
Streptococcus pneumoniae
160
Bacteria associated with
hospital-acquired infections,
cystic fibrosis and
neutropenic patients
Pseudomonas aeruginosa
161
Viral pneumonia linked to
Parkinson's disease later in
life
Influenza virus type A
162
Stage of lobar pneumonia
where the lungs are heavy
and boggy; Vascular
engorgement, intra-alveolar
fluid with few neutrophils,
numerous bacteria
Congestion
163
Stage of lobar pneumonia
where the lungs are red, firm,
airless with a liver-like
consistency. (+) intra alveolar
PMNs, RBCs, fibrin
Red Hepatization
164
Microscopic finding of the
lungs in viral pneumonia
Interstitial mononuclear
inflammation
165
Most common cause of lung
abscess
Aspiration
166
Most common primary lung
tumor
Lung carcinoma
167
Type of lung carcinoma
associated with
paraneoplastic syndromes;
strongest association with
smoking
Small cell carcinoma
168
Most common histologic type
of lung cancer; most common
type in never smokers;
peripheral in location
Adenocarcinoma
169
Type of lung cancer that is
central in location; (+)
keratinization, keratin pearls,
intercellular bridges
Squamous cell carcinoma
170
IHC stains positive in
carcinoid tumor
Synaptophysin,
Chromogranin
171
Cannon-ball lesions or
multiple discrete lesions in
the lung is typical of
Metastatic neoplasm
172
Most common cause of noninflammatory
transudative
effusions
Congestive heart failure
173
Mechanism of pleural effusion
in CHF
↑Capillary hydrostatic
pressure
174
Type of effusion associated
with radiation, autoimmune
disease, uremia
Serous, serofibrinous,
fibrinous
175
Type of effusion associated
with thoracic duct trauma
Chylous
176
Pneumothorax sufficient to
cause circulatory collapse due
to compression of mediastinal
structures
Tension pneumothorax
177
Type of pneumothorax that
occur due to rupture of
subpleural blebs in young
patients
Spontaneous idiopathic
pneumothorax
178
Most common pleural tumors
Secondary tumors (common
sources: lung, breast)
179
Most common cause of tooth
loss < 35 years old
Dental caries
180
Associated conditions with
recurrent/persistent
aphthous ulcers
Celiac disease,
Inflammatory bowel
disease, Behçet disease,
immunocompromised
181
Most common fungal
infection of oral cavity
Candida albicans
182
White pseudomembrane that
can be scraped off
Thrush
183
A white patch or plaque that
cannot be scraped off and
cannot be characterized
clinically or pathologically as
any other disease
Leukoplakia
184
Most common head and neck
cancer
Squamous cell carcinoma
185
Etiology of oral cavity SCCa
Tobacco, Alcohol, Betel
chewing, Sunlight, Pipe
smoking
186
Most common site of local
metastasis of oral cavity SCCa
Cervical lymph nodes
187
Etiology of oropharyngeal
SCCa
High-risk HPV
188
Odontogenic cysts located in
impacted/unerupted tooth
Dentigirous cyst
189
Condition associated with
multiple odontogenic
keratocyst
Gorlin syndrome (Nevoid
basal cell carcinoma
syndrome)
190
Odontogenic cyst associated
with history of dental
caries/trauma; location: apex
of non-viable tooth
Radicular cyst
191
Most common odontogenic
tumor
Odontoma
192
A patient presents with a
mass on the right mandible
in the posterior molar area.
Biopsy: epithelial cells
palisading around a stellate
reticulum.
Ameloblastoma
193
Most common cause of
bacterial
pharyngitis/tonsillitis
Group A beta-hemolytic
streptococci (GABHS)
194
An adolescent male presents
with recurrent epistaxis and
nasal obstruction. A mass
was seen in the posterior
roof of the nasal cavity
Sinonasal tract
angiofibroma
195
Virus associated with
nasopharyngeal carcinoma
(NPCA)
Epstein-Barr virus
196
Most common location of
NPCA
Rosenmuller fossa
197
Most radiosensitive type of
NPCA
Undifferentiated NPCA
198
Laryngeal lesion associated
with voice abuse
Reactive nodules
199
Most common benign
laryngeal epithelial tumor
Squamous papilloma
200
Etiology of laryngeal
papilloma
Low-risk HPV (6 and 11)
201
Common bacterial causes of
acute otitis media
S. pneumoniae, H.
influenzae, M. catarrhalis
202
Origin of branchial cleft cyst
2nd branchial arch
remnant
203
Most common cause of
xerostomia
Drugs (Anticholinergics,
Antihistamines,
Antipsychotics,
Antidepressants)
204
Most common inflammatory
salivary gland lesion
Mucocele
205
Salivary gland lesions that
occurs following sublingual
duct damage
Ranula
206
Most common viral
sialadenitis
Mumps
207
Bacterial sialadenitis can
occur in the presence of
Sialolithiasis
208
Most common salivary gland
tumor
Pleomorphic adenoma or
benign mixed tumor
209
Salivary gland tumor
associated with smoking;
Morphology: papillary
structures with central
lymphoid stroma covered by
double layer of oncocytic
cells
Warthin Tumor
210
Most common primary
malignant salivary gland
tumor
Mucoepidermoid
carcinoma
211
Most common location of
pleomorphic adenoma,
mucoepidermoid carcinoma,
and Warthin tumor
Parotid gland
212
A cancer arising from a
primary or recurrent
pleomorphic adenoma
Carcinoma ex pleomorphic
adenoma
213
Most common location of
adenoid cystic carcinoma
Minor (palatine) glands
214
Most common form of
adenoid cystic carcinoma
Cribriform
