Radiation oncology Flashcards

1
Q

what are the top 3 cancer cases for men in the US?

A
  1. prostate
  2. lung
  3. colon and rectum
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2
Q

what are the top 3 cancer cases for women in the US?

A
  1. breast
  2. lung
  3. colon and rectum
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3
Q

what are the top 3 cancer deaths for men in the US?

A
  1. lung
  2. prostate
  3. colorectal
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4
Q

what are the top 3 cancer deaths for women in the US?

A
  1. lung
  2. breast
  3. colorectal
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5
Q

what is the staging for lymph node mets?

A

N

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6
Q

what is the staging for hematogenous mets?

A

M

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7
Q

what is the staging for adjacent organ tumor invasion?

A

T3-4

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8
Q

what is the role of radiation in tumor treatment?

A

to replace or complement surgery

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9
Q

what particle is used for deep seated tumors?

A

photons (x rays)

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10
Q

what particle is used for superficial tumors?

A

electrons

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11
Q

definition: radiosensitive

A

tumor melts with RT - does not depend on kinetics

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12
Q

definition: radioresponsive

A

tumor melts quickly

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13
Q

what are classic examples of tumors that are both radiosensitive and radioresponsive?

A

lymphoma, small cell lung

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14
Q

what is the main target for radiation therapy? what is the most important lesion produced?

A
  1. DNA of well oxygenated tumors in M/G2 phase

2. double strand DNA break

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15
Q

what is the radiosensitive phase of a tumor?

A

M/G2

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16
Q

what is the radioresponsive phase of a tumor?

A

S

17
Q

what biological process is essential to radiation cell kill over time?

A

reoxygenation

18
Q

GTV

A

gross tumor volume - seen with naked eye

19
Q

CTV

A
  1. margin on GTV to account for tissue with presumed tumor / typical site of disease spread
  2. assumes no tumor cells outside this volume
20
Q

ITV

A

CTV plus internal margin for physiological movements / error

21
Q

PTV

A

CTV or ITV plus setup margin uncertainty / error

22
Q

what is IGRT?

A

a way to verify with greater precision the tumor’s position to allow for more accurate treatment

23
Q

what are the indications for IGRT?

A
  1. tumors that move

2. tumors abutting critical structures such as spinal cord and brainstem

24
Q

what are the two types of IGRT?

A
  1. stereoscopic / bony

2. cone beam / soft tissue

25
Q

what is stereoscopic / bony IGRT?

A

uses bone structure as template for alignment

26
Q

what is cone beam / soft tissue IGRT?

A

uses a same-day CT for fusion to simulation image