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Year 2 Hematology > Pathology of lymphomas > Flashcards

Pathology of lymphomas Flashcards

1
Q

follicular lymphomas are composed of what cell types?

A

follicle germinal center cells - centroblasts and centrocytes

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2
Q

follicular lymphoma is positive for what main markers?

A

CD10, Bcl-2

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3
Q

follicular lymphoma is negative for what markers?

A

CD5, CD3

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4
Q

how does mantle cell lymphoma present?

A

male, 5th to 6th decade

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5
Q

mantle cell lymphoma is positive for what main markers?

A

CD5, cyclin D1

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6
Q

mantle cell lymphoma is negative for what markers?

A

CD23, CD3

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7
Q

all patients with Burkitt lymphoma are at risk of disease involvement with which system?

A

CNS

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8
Q

what is the morphology of Burkitt lymphoma?

A
  1. diffuse monomorphic infiltrate of intermediate sized round to slightly irregular lymphoid cells with multiple peripherally placed nucleoli
  2. tingible body macrophages (“starry sky”)
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9
Q

what is a tingible body macrophage? where are they normally found?

A
  1. contains phagocytized, apoptotic cells in various states of degradation
  2. germinal centers
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10
Q

Burkitt lymphoma is positive for which markers?

A

CD10, CD19, CD20

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11
Q

Burkitt lymphoma is negative for which markers?

A

Bcl-2

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12
Q

what is the cause of adult T cell leukemia / lymphoma?

A

human T cell leukemia virus type 1 (HTLV-1) retrovirus

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13
Q

adult T cell leukemia often presents with what condition?

A

hypercalcemia

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14
Q

adult T cell leukemia is a neoplastic proliferation of what cell type?

A

CD4 positive T cells

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15
Q

flower cells are indicative of what condition?

A

adult T cell leukemia

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16
Q

what is the morphology of mycosis fungoides?

A

cerebriform nuclei - folded nuclear membrane

17
Q

what are the phases of mycosis fungoides?

A

plaque and tumor phases

18
Q

what is the morphology of T cell ALL?

A
  1. monotonous population of blasts
  2. may have more clumped chromatin
  3. sheets of blasts in lymph node, soft tissue, BM
19
Q

T cell ALL is positive for what markers?

A

CD34, TdT, CD1a, cytoplasmic CD3

20
Q

anaplastic large cell lymphoma is positive for what marker in younger patients?

A

ALK-1 (anaplastic lymphoma kinase 1)

21
Q

what is the morphology of anaplastic large cell lymphoma?

A

pleomorphic with characteristic “Hallmark” cells:

  1. medium
  2. abundant cytoplasm
  3. kidney shaped nuclei
  4. paranuclear eosinophilic region
22
Q

anaplastic large cell lymphoma is positive for what markers?

A

CD30 and ALK

23
Q

mycosis fungoides is a neoplastic proliferation of what cell type?

A

CD 4 positive T cells

Year 2 Hematology (34 decks)

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