Hemolytic anemia

Question 1

what are the haptoglobin levels in hemolytic anemia? why?

Answer 1

1. decreased

2. taking away all the Hb

Question 2

what are the LDH levels in hemolytic anemia? why?

Answer 2

1. elevated

2. RBC breakdown

Question 3

what are the reticulocyte levels in hemolytic anemia? why?

Answer 3

1. elevated

2. hyperproliferative bone marrow

Question 4

what is the result of a Coomb’s test in hemolytic anemia? why?

Answer 4

1. positive

2. Ab or complement mediated hemolysis

Question 5

what are the indirect bilirubin levels in hemolytic anemia? why?

Answer 5

1. elevated

2. RBC breakdown

Question 6

what are the urine hemosiderin levels in hemolytic anemia? why?

Answer 6

1. high

2. intravascular hemolysis

Question 7

what is the most common enzymatic disorder of hemolytic anemia? what is the inheritance?

Answer 7

1. G6PD

2. x linked

Question 8

heinz bodies and bite cells are seen with what condition?

Answer 8

G6PD deficiency hemolytic anemia

Question 9

what is the pathogenesis of sickle cell anemia?

Answer 9

1. mutation in B globin gene
2. both B globin genes affected
3. deoxygenated Hb S stiffens RBC membrane

Question 10

patient who have sickle cell anemia are prone to what type of organisms?

Answer 10

encapsulated and salmonella

Question 11

what are the drug associated hemolysis?

Answer 11

penicillins, quinine, methyldopa, certain cephalosporin abx