Rabdovirus Flashcards
Retroviruses have a diploid genome. This means:
- They have two segments of dingle stranded, positive sense RNA
- They have two nucleocapsids
- They have a double stranded RNA
- They have a double envelop
They have two segments of dingle stranded, positive sense RNA
The reverse transcriptase is required for:
- Copying cDNA from viral RNA during retroviral replication
- Retroviral exocytosis
- Retroviral entry into cells
- Retroviral integration into host genome
Copying cDNA from viral RNA during retroviral replication
Where does the reverse transcriptase required for copying cDNA from viral RNA come from?
- It is de novo synthesized in the infected cell mitochondria
- Since RNA viruses use cellular mechanisms for replication, the source of RT is the host cell
- RT is found on the surface of the infected cell
- The RT is virion-associated
RT is found on the surface of the infected cell
Where in the infected cell does reverse transcription of the retroviral RNA take place?
- Cytoplasm
- Nucleus
- Mitochondria
- Endothelial reticulum
Cytoplasm
What is a provirus?
- The genetic material of a virus as incorporated into, and ale to replicate with, the genome of a host cell
- RNA derived from a bacterial virus
- Another name for prions
- Any type of DNA incorporated into a cell
The genetic material of a virus as incorporated into, and ale to replicate with, the genome of a host cell
Where in the host genome does the retroviral dsDNA integrate?
- There is no one site specificity for viral dsDNA integration
- Only at sites where proto-oncogenes are located
- At sites where introns are situated
- Integration takes place only between exons
There is no one site specificity for viral dsDNA integration
What does the pol gene of retroviruses encode?
- Reverse transcriptase and integrase
- Protease
- Surface (SU) and transmembrane (TM)
- Capsid (CA), nucleocapsid (NC), matrix (MA)
Reverse transcriptase and integrase
FIV can infect
- CD4+ T lymphocytes
- All of the above
- Platelets
- Microglial cells
- CD4+ T lymphocytes
The most important route of FIV in domestic cats is:
- Sexual contact
- Grooming, exclusively
- Fomites
- Bite wounds
- Bite wounds
FELV has tropism to cells of the immune system such as T cells
- True or false
True
During which virus infection can lymphoma and leukemia develop?
- NDV
- FeLV
- Influenza A
- Swine poxvirus
- FeLV
What outcome of retrovirus infection do you know?
- Cellular transformation
- Latent infection
- Chronic infection
- All of the above
- All of the above
Acute transformation by retroviruses is mediated y oncogenes
- True or false
True
What type of cellular transformation do retroviruses cause by insertion or mutation through random integration
- None of the above
- Chronic transformation
- Blastic transformation
- Acute transformation
- Chronic transformation
A non-vaccinated cat can have antibodies against FeLV even though it has not been infected with an exogenous FeLV
- True or false
True
