Paramyxoviridae

Question 1

Paramyxoviruses can replicate in enucleated cells or cells treated with actinomycin D
True
False

Answer 1

True

Question 2

Which of the following replication strategies fit the paramyxovirus?
A. Cytoplasmic uncoating and reverse transcription, nuclear dsDNA integration in host genome and transcription, cytoplasmic protein translation, virion assembly and budding
B. Nuclear uncoating, cytoplasmic synthesis of mRNA and RNA(+), translation of non-structural proteins, assembly of virions
C. Cytoplasmic uncoating, nuclear synthesis of mRNA, and cRNA(+) and vRNA(-), cytoplasmic translation of proteins, virion assembly and budding
D. Cytoplasmic uncoating, cytoplasmic synthesis of both mRNA and +RNA, cytoplasmic translation of structural proteins from mRNA, cytoplasmic synthesis vRNA(-) from +RNA, virion assembly and budding

Answer 2

D. Cytoplasmic uncoating, cytoplasmic synthesis of both mRNA and +RNA, cytoplasmic translation of structural proteins from mRNA, cytoplasmic synthesis vRNA(-) from +RNA, virion assembly and budding

Question 3

Replication of paramyxovirus occurs primarily in this location: 
A. Mitochondria
B . Nucleus
C. Endothelial reticulum
D.  Cytoplasm

Answer 3

D. Cytoplasm

Question 4

How many types of glycoprotein spikes are there on the surface envelope of Paramyxoviridae? 
A. 2
B. 1
C. 4
E. 3

Answer 4

A. 2

Question 5

According to the FAO and OIE, Rinderpest has been eradicated
True
False

Answer 5

True

Question 6

Giant, multinucleated cells that develop during paramyxovirus replication are also known as a what? 
A.Synclines
B. Syncytia
C.Syncopates
D. Synchrotrons

Answer 6

B. Syncytia

Question 7

AVPM-1 is a member of what sub-family of viruses?
 A.Paramyxovirinae
B. Filovirinae
C.Retrovirinae
D. Orthomyxovirinae

Answer 7

A.Paramyxovirinae

Question 8

Nipah virus naturally infects fruit bats, humans and swine are NOT susceptible.
True
False

Answer 8

False

Question 9

To which family of viruses do the Paramyxovirinae and Pneumovirinae belong? 
  A.Paramyxvoviridae
B.Birnaviridae
C.Orthomyxoviridae
D. Rhabdovirdae

Answer 9

A.Paramyxvoviridae

Question 10

Members of the Paramyxoviridae do not require nuclear function to replicate
True
False

Answer 10

True

Question 11

Syncytium is formed in cell culture following infection with Paramyxovirus. Syncytium is:

A.Formation of large, multinucleated cells in culture
B.Formation of synchrotrons in cells infected with APMV-1
C. Formation of synclines in infected cells
D. Formation of syncopates in cell culture

Answer 11

B.Formation of synchrotrons in cells infected with APMV-1

Question 12

12. Which of the following are pathotypes of APMV-1 (NDV)? (Points : 2)

Lentogenic
Mesogenic
Velogenic (viscerotropic/neurotropic)
All of the above

Answer 12

All of the above

Question 13

Nipah virus is an emerging zoonosis
True
False

Answer 13

True

BSL -4**

Question 14

Secondary immunodeficiency is likely to develop during canine distemper. Why?
destruction of nasal epithelial tissue
destruction of nasal associated lymphoid tissue
destruction of dendritic cells, macrophages, thymocytes and activated T cells
destruction of the nervous system

Answer 14

destruction of dendritic cells, macrophages, thymocytes and activated T cells

Question 15

What receptor should be expressed on a cells for the canine distemper virus to infect that cell? 
CD4
CD150
CXCR4
CCR5

Answer 15

CD150

Question 16

Canine distemper in dogs is now a rare disease in North America. Why?
all virus reservoirs have been eliminated
quarantine and elimination of infected dogs
systematicvaccination of dogs
the virus has been eradicated

Answer 16

systematicvaccination of dogs

Question 17

17. You are called on to a puppy that has been bitten by a raccoon. The client managed to capture the raccoon. Upon visual examination of the raccoon you notice neurological signs similar to canine distemper. Is there anything you could do to prevent canine distemper in the non-vaccinated puppy?
    Yes, administer hyperimmune serum against canine distemper virus
    Nothing can be done, just dress the bite wound and hope for the best.
    Yes, vaccinate immediately
    No, the puppy should be quarantined and eliminated if canine distemper develops

Answer 17

Yes, administer hyperimmune serum against canine distemper virus

Question 18

Further consider the events in the previous question. What other suspicion could arise regarding the state of the raccoon?

it could be infected with the rabies virus
it could be infected with a feline retrovirus
the raccoon could have drunk some alcohol found in the dumpster, hence gait abnormality
it could be infected with the classical swine fever virus

Answer 18

it could be infected with the rabies virus

Question 19

Samples from chicken suspected of velogenic NDV infection should be sent to:

any laboratory that can process the samples
nearest diagnostic laboratory as soon as possible
the best diagnostic laboratory in the country
a reference laboratory

Answer 19

a reference laboratory

Question 20

During an outbreak of FMD, what disinfectant, in form of soaked mats, would you choose to safeguard the entrance to animal houses? 
picric acid
sodium hydrogen sulphate
sulphuric acid
soda ash

Answer 20

soda ash