RAAS

Question 1

What is the role of the RAAS in homeostasis? (3 marks)

Answer 1

regulates blood pressure, fluid volume and electrolyte levels e.g. sodium and potassium

Question 2

What are the components of the RAAS system?

Answer 2

Angiotensinogen, Renin, ANG1, ACE, ANG2 and aldosterone

Question 3

What are the effects of ANG2 on AT1 receptors (6 marks)

Answer 3

vasoconstriction, release of aldosterone, noradrenaline release, hypertrophy, thirst and release of ADH.

Question 4

What are the effects of ANG2 on AT2 receptors (3 marks)

Answer 4

increased sodium and water resorption and potassium excretion

Question 5

What is the effect of an ACEI on the RAAS?

Answer 5

reduce ANG2 levels (inhibit production) and increase bradykinin (inhibits breakdown)

Question 6

What is the effect of ANG2 receptor antagonists (sartans) on the RAAS?

Answer 6

competitive antagonist of ANG2 at AT1 receptors. They don’t antagonise ang2 effects when stimulated at AT2 receptors or inhibit ANG2 production or bradykinin breakdown