quiz 4 (exam 2)

Question 1

potency

Answer 1

= efficacy + affinity

Question 2

Endocanabinoid Receptor

Answer 2

endogenous ligand of camabinoid receptors

Question 3

anandamide

Answer 3

endocanabinoid
endogenous substance that binds the cannabinoid receptor molecule

Question 4

Psilocybin

Answer 4

partial agonist of 5-HT2A Receptors in visual cortex
change in activity of frontal & occipital cortex
Hallucinogen

Question 5

Ketamine

Answer 5

Block NDMA receptors (antagonist)
stimulate opiod and Ach receptors
help treat depression
Hallucinogen

Question 6

MDMA

Answer 6

partial agonist of 5-HT2A Receptors in visual Cortex
stimulate release of dopamine
decrease symptoms of PTSD w/ psych therapy
Hallucinogen

Question 7

LSD `

Answer 7

resembles serotonin
partial agonist of 5-HT2A receptor in visual Cortex
activates DA Receptors

Question 8

1st generation antipsychotics

Answer 8

block D2 receptors
relieve positive symptoms

Question 9

2nd generation antipsychotics

Answer 9

relieve negative symptoms
block some serotonin receptors & D2

Question 10

Benzodiazepines

Answer 10

agonist of GABAa Receptors (inhibitory)
decreases excitability of neurons
xanax and active
anti anxiety drug

Question 11

Barbiturate

Answer 11

anti anxiety drug
sleep aid
addictive
phenobarbital

Question 12

Novel Anxiolytics

Answer 12

anti anxiety drug
hormones that interact w GABA receptors
subtle alter antidepressants

Question 13

Low Ligand Binds to what kind of affinity

Answer 13

high affinity
how strongly receptor binds

Question 14

Functional Tolerance

Answer 14

up / down regulation

Question 15

down regulation

Answer 15

decreased number of receptors
after repeated dose of agonist drug

Question 16

up-regulate

Answer 16

increase number of receptors
repeated dose of antagonist drug

Question 17

Cocaine

Answer 17

blocks reuptake of & enhances DA & NE transmitters
stimulant

Question 18

Nicotine

Answer 18

simulates nicotine acetylcholine receptors
agonist on large class of cholinergic receptors
stimulant

Question 19

Methamphetamine

Answer 19

Reverses the function of DA, SA, NE transporters
results in more DA,SA,NE in the synapse

Question 20

Ingestion

Answer 20

slow - moderate

Question 21

inhalation

Answer 21

moderate - fast

Question 22

peripheral injection

Answer 22

vaccine
moderate - fast

Question 23

Central Injection

Answer 23

Fast - very fast

Question 24

Autoreceptor

Answer 24

tells axon terminal how much transmitter has been released
feedback system
presynaptic transmitter release

Question 25

Reuptake Inhibitors

Answer 25

Block presynaptic system that normally reabsorbs transmitter molecules after their release
presynaptic transmitter clearance

Question 26

Presynaptic Drug Effects: Production

Answer 26

inhibit neurotransmitter synthesis
block axonal transport
interfere w/ storage of transmitters

Question 27

Postsynaptic drug effects on transmitter receptors

Answer 27

block receptors - antagonist
activate receptors - agonist

Question 28

postsynaptic intracellular processes

Answer 28

alter # of postsynaptic receptors
modulate 2nd messengers

Question 29

nucleus accumbens

Answer 29

reward & pleasure

Question 30

insula

Answer 30

addiction, craving, pleasure
within folds of frontal cortex

Question 30

insula

Answer 30

addiction, craving, pleasure
within folds of frontal cortex

Question 31

synesthesia

Answer 31

music notes look a certain color

Question 32

polymodal neurons

Answer 32

`info from more than 1 sensory system converge

Question 33

hierarchy of motor planning system

Answer 33

1. primary motor cortex - initiates
2. non primary motor cortex - indirect
3. cerebellum and basal ganglia - modulate activities via thalamus
4. brainstem - integrates motor commands & relay to spinal cord
5. spinal cord - contracts skeletal muscle response to motor commands
6. skeletal system - determines which movements are possible