Quiz 10, Chapter 10 Flashcards
The aim of preclinical pharmacological studies is to obtain data on the safety and effectiveness of the lead compound.
True.
Toxicity information in preclinical studies helps provide confidence about a drug’s safety.
True.
Pharmacological studies using animals are regulated under Good Laboratory Practice.
True.
Why do drugs administered to patients only contain APIs?
They don’t.
A drug’s vesicles affect it’s ability to permeate membranes.
True.
Through which barriers can lipid-soluble drugs usually pass?
Cell membranes.
How are weak acid drugs generally absorbed by the stomach?
More quickly than weak basic drugs.
Which route of administration does not completely bypass the liver?
Rectal administration.
Why are intravenous drug dosages easier to control than drugs administered transdermally?
The entire dose is available in the bloodstream to be distributed to the target site.
A drug’s lipid-solubility, polarity, and the __________ ___________ of the drug’s target tissue affect it’s distribution.
vascular nature
What medical term means “to apply the drug on the surface of the skin”?
Transdermal.
Carcinogenicity studies are carried out to identify the tumor-causing potential of a drug.
True.
