Quinolones

Question 1

Mechanism of action of quinolones

Answer 1

Broad spectrum and bactericidal, inhibits DNA synthesis

Question 2

MHRA alerts for quinolones (what increases risks)

Answer 2

• May induce convulsions w or w/ history. Taking NSAIDs concurrently can induce
• Tendon damage (within 48 hours or several months after). CI in those with quinolone-related tendon disorders, >60 (more prone to tendon dmg), increased risk of also taking corticosteroids, stop immediately if suspected
• Aortic aneruysm and dissection
• Disabling and potential long-lasting irreverislbe SEs (MSK and NS)
• Heart valve regurgitation - report SoB (esp when lying down), swelling ankles, feet, abdomen, new palpitations)

Question 3

Ciprofloxacin counselling

Answer 3

Do not take milk, indigestion remedies, or medicines containing iron or zinc, 2 hours before or after you take this med

Question 4

General SEs of quinolones

Answer 4

Convulsions, QT interval prolongation, c.diff, hypersensitivty, GI upset, rupture of muscle tendons

Question 5

Interactions of quinolones

Answer 5

Drugs that pro-long QT interval - corticosteroids, Methotrexate, NSAIDs, theophylline

Question 6

Interaction ciprofloxacin

Answer 6

Decrease phenytoin levels