Penicillins

Question 1

Mechanism of action of penicillins

Answer 1

Broad spectrum and bactericidal - interfere with cell wall synthesis

Question 2

Penicillin G vs Penicillin V and their assoc. properties

Answer 2

Pen G - Benzylpenicillin (inactivated by gastric acid and therefore given parentally
Pen V - Phenoxymethylpenicillin (similiar spectrum less active than pen g, active orally, should be taken on an empty stomach

Question 3

Penicillinase-resistant penicillin

Answer 3

Flucloxacillin and Temocillin

Question 4

Flucloxacillin counselling

Answer 4

Take on an empty stomach, QDS dosing

Question 5

MHRA flucloxacillin

Answer 5

Hepatic disorders

- cholestatic jaundice and hepatitis occur very rarely up to two months after tx stopped. RF >2 weeks and age

Question 6

Why should broad-spectrum penicillins not be used as blind treatment of sore throats

Answer 6

Maculopapular rash in people with glandular fever

Question 7

Examples of broad-spectrum penicillins

Answer 7

Ampicillin, amoxicillin and co-amoxiclav

Question 8

Out of amoxicllin and ampicilin, which is better absorbed

Answer 8

Amoxicillin

Question 9

Antipseudomonal penicillins

Answer 9

Piperacillin + tazobactam (b lactamase inhibitor)

Question 10

Allergic reactions penicillins - what %

Answer 10

1-10%