Carbapenems

Question 1

Name some carbapenems

Answer 1

Meropenem
Ertapenem
Imipenem

Question 2

What does imipenem need to be co-administered with and why?

Answer 2

Cilastatin as partially inactivated in the kidney by enzymatic activity, which is an enzyme inhibitor, blocking the activity

Question 3

What kind of antibacterials are carbapenems, what spectrum of activity do they have and what bacteria do they targret?

Answer 3

beta-lactam

broad spectrum including g- and g+ anaerobes

Question 4

What serious side effect can carbapenems cause (which one least likely to cause this)

Answer 4

Seizures - meropenem (can actually be used to treat CNS infections)

Question 5

Which carbapenems and are active pseudomonas aeruginosa

Answer 5

Meropenem and imipenem

Question 6

Interactions

Answer 6

Decrease the conc of sodium valporate to as low as 10% (increasing dose of sodium valporate does not counteract this interaction)