Glycopeptides

Question 1

Name some glycopeptides

Answer 1

Dalbavancin, telavancin, teicoplanin and vancomycin

Question 2

Which of these glycopeptides are active against anaerobic and aerobic g+ bacteria (incl MRSA)

Answer 2

Telavancin, teicoplanin and vancomycin

Question 3

What glycopeptide has a long duration of action so can be given OD (after loading dose)

Answer 3

Teicoplanin

Question 4

What glycopeptide is associated with the most nephrotoxicity

Answer 4

Vancomycin

Question 5

What have late reports shown as a bacteria becoming more resistant to glycopeptides

Answer 5

Staph aureus

Question 6

Which bacteria do these glycopeptides target

Answer 6

G- (cannot penetrate porins of g- organisms)

Question 7

Glycopeptide infusion vs bolus

Answer 7

Vancomycin - Infusion

Teicoplanin - bolus

Question 8

Side effects of glycopeptides

Answer 8

Red man syndrome - if infused too fast
Nephrotoxicity
Ototoxicity

Question 9

Vancomycin trough level

Answer 9

10-15 (15-20 in more deep seated infections, endocarditis and osteomyltitis)

Question 10

Vancomycin c diff dose

Answer 10

125mg QDS for 10-14 days