Questions (Random) - UWorld

Question 1

Kussmaul sign

Answer 1

Increased JVP on inspiration

Right heart failure

Question 2

Direct thrombin inhibitors

Answer 2

Dabigatran (oral)
Bivalirudin
Argatroban

Question 3

Factor Xa inhibitors

Answer 3

Rivaroxaban
Apixaban
Fondaparinux (indirect)

Question 4

Drugs that enterococcus is often resistant to

Answer 4

Vancomycin
Aminoglycosides
Penicillins
TMP-SMX

Question 5

Aminoglycosides - resistance

Answer 5

Chemical alteration (acetylation, adenylation, phosphorylation)

Question 6

Rifamycin - resistance

Answer 6

Mutated RNA polymerase

Question 7

Tropical spastic paresis

Answer 7

HTLV-1 w/ upper motor neuron symptoms

Question 8

LAD, HSM, rash, hypercalcemia

Answer 8

Adult T-cell Leukemia/Lymphoma

Question 9

Pneumatosis intestinalis

Answer 9

Air in the bowel wall - necrotizing enterocolitis

Question 10

MI…

• 4-12 hours
• 2-3 days
• 5-7 days
• 7 weeks

Answer 10

Coag. necrosis (wavy fibers/contraction bands)
Neutrophils
Histiocytes, lymphocytes, granulation tissue
Scar

Question 11

MCTD - genetic issue?

Answer 11

U1-RNP – splicing issue

Question 12

Desmoplasia

Answer 12

Injured normal tissue by cancer, etc. –> fibrosis, etc.

Question 13

Frontal balding
Gonadal atrophy
Cataracts
Rigid muscle(s)

Genetics?

Answer 13

Myotonic dystrophy

CTG repeat

Question 14

Function of dystrophin

Answer 14

Protects from degradation of glycoprotein complexes in the cytoplasm of skeletal muscle cells

Question 15

Cardiac output/Venous return curve…

• Increased slope of the lines?
• Rightward shift of venous return curve?

Answer 15

Increased slope = decreased TPR

Rightward VR curve = increased systemic pressure

Question 16

Expected CO2 following metabolic acidosis

If it’s higher than the real value?
Example?

Answer 16

Winters formula: 1.5(CO2) + 8 +/- 2

Respiratory alkalosis also
Salicylate poisoning

Question 17

Calmodulin-dependent adenylate cyclase toxin (2)

Answer 17

Edema factor (anthrax)
Adenylate cyclase toxin (pertussis)

Question 18

Subarachnoid hemorrhage –> 2-3 days later ischemic infarct

Answer 18

Vasospasm

Question 19

MC anal fissure location

Answer 19

Posterior, midline below the dentate line

Question 20

Familial Alzheimer’s - early vs. late

Answer 20

Early = APP, Presenilin 1 or 2
Late = Apo-E4