Immuno

Question 1

CD28

Fxn

Answer 1

T cells

Binds B7 on APCs

Question 2

CD40L

Fxns

Answer 2

Helper T cells

Bind B cells for class switching
Bind Macrophages for increased intracellular killing

Question 3

CD25

Answer 3

T helper cells (w/ CD4)

Question 4

CD21

Answer 4

B cells - EBV receptor

Question 5

CD40

Answer 5

B cells, Macrophages

Question 6

B7

Fxn

Answer 6

B cells, Macrophages

Binds CD28 – Co-receptor w/ MHC II-TCR binding

Question 7

CD14
Fxn

Result?

Answer 7

Macrophages, Dendritic cells
Receptor for LPS (PAMP) - endotoxin

NF-kB upregulation –> cytokines, etc.

Question 8

CCR5

Fxn

Answer 8

Cytotoxic T cells, Macrophages

Co-receptor for HIV

Question 9

Fc and C3b receptors

Fxn

Answer 9

Macrophages

Enhanced phagocytosis

Question 10

CD16

Fxn

Answer 10

NK cells and Macrophages

Binds Fc portion of IgG

Question 11

CD56

Answer 11

NK cells (unique)

Question 12

Fxn of superantigens

Answer 12

Cross-link TCR-MHC II binding –> enhanced CD4 T cell activation –> massive cytokine release

Question 13

Fxn of endotoxin/LPS

Answer 13

Binds CD14 on Macrophages to stimulate cytokine release (no T cells involved)

Question 14

Live attenuated vaccines (8)

What type of response?

Answer 14

BCG, influenza (nasal), MMR, Polio (Sabin), Varicella, Yellow fever

Cellular and Humoral

Question 15

Inactive/killed vaccines (4)

What type of response?

Answer 15

Rabies, Influenza (injection), Polio (Salk), Hep A

Question 16

Anti-phospholipase A2 antibody

Answer 16

Primary membranous nephropathy

Question 17

Anti-smooth muscle antibody

Answer 17

Autoimmune hepatitis type 1

Question 18

When to give pre-formed antibodies?

Answer 18

After unvaccinated exposure to…

- Tetanus, Botulinum, HBV, Varicella, Rabies

Question 19

HLA-B8

Answer 19

Addison’s Disease

Myathenia Gravis

Question 20

RA - HLA?

Answer 20

DR4 (“4 walls in a rheum”)

Question 21

Pernicious anemia - HLA?

Answer 21

DR5

Question 22

Graves disease - HLA?

Answer 22

DR3