Pyrimidine Synthesis (Nucleotide Synthesis)

Question 1

what is the parent molecule of Pyrimidine synthesis?

Answer 1

UMP

(Uracil Monophosphate)

Question 2

sources of Nitrogen atoms in Pyrimidine synthesis

Answer 2

Aspartate, Glutamine

Question 3

sources of Carbon atoms in Pyrimidine synthesis

Answer 3

CO2, Aspartate

Question 4

what 2 enzymes are needed for Pyrimidine synthesis?

Answer 4

CAD, UMP-Synthase

Question 5

what AA + high energy molecule is needed to convert UMP –> CTP

Answer 5

Glutamine + ATP

Question 6

what enzyme converts dUMP –> dTMP

Answer 6

N5 N10 Methylene-THF

(4Hfolate) or (tetra-hydra-folate)

Question 7

what classification of drugs blocks the conversion of dUMP –> dTMP ? give one example of this class of drugs

Answer 7

Cancer drugs

(folate inhibitors, ex: Methotrexate)

Question 8

what is the energy source to convert TMP –> TTP

Answer 8

ATP

Question 9

what enzyme + coenzyme converts Ribonucleotides –> Deoxynucleotides ?

Answer 9

Ribonucleotide reductase; NADPH

Question 10

what diseases are caused by degradation of Pyrimidines?

Answer 10

None