Degradation of Purines (Nucleotide Synthesis) Flashcards

Nucleotide Synthesis

1
Q

what water-soluble molecule is produced from Purine degradation?

A

Xanthine

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2
Q

what less water-soluble molecule is produced from Purine degradation?

A

Uric Acid

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3
Q

what enzyme degrades Purines, and what does it require?

(does the conversion Hypoxanthine –> Xanthine –> Uric Acid)

A

Xanthine Oxidase; Mo

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4
Q

what drug blocks the enzyme Xanthine Oxidase?

A

Allopurinol

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5
Q

what natural food acts like Allopurinol?

(blocks enzyme Xanthine Oxidase)

A

Bing Cherry Juice

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6
Q

define Gout

A

increased Uric Acid in the blood; termed Uricemia

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7
Q

what is the cause of gouty arthritis?

A

Na+ Urate Crystals deposit in joints

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8
Q

what is Gout in the big toe termed

A

Podagra

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9
Q

what is the Genetic predisposition for gout?

A

X-linked recessive gene (90% male sufferers)

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10
Q

what foods are high in Purines?

A

organ meats, aged cheese, alcohol

(beer, wine)

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11
Q

what disease is caused by genetic enzyme deficiency of HGPRT?

A

Lesch-Nyhan Syndrome

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12
Q

what are the symptoms of Lesch-Nyhan Syndrome?

A

Gouty arthritis, mentally challenged, self mutilation (ex. chew finger tips off)

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13
Q

what disease is caused by genetic enzyme deficiency of Glucose-6-Phosphatase?

A

Von Gierke’s Disease

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14
Q

what are the symptoms of Von Gierke’s Disease?

A

Hypoglycemia, gout, glycogen build up

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