Degradation of Purines (Nucleotide Synthesis)

Question 1

what water-soluble molecule is produced from Purine degradation?

Answer 1

Xanthine

Question 2

what less water-soluble molecule is produced from Purine degradation?

Answer 2

Uric Acid

Question 3

what enzyme degrades Purines, and what does it require?

(does the conversion Hypoxanthine –> Xanthine –> Uric Acid)

Answer 3

Xanthine Oxidase; Mo

Question 4

what drug blocks the enzyme Xanthine Oxidase?

Answer 4

Allopurinol

Question 5

what natural food acts like Allopurinol?

(blocks enzyme Xanthine Oxidase)

Answer 5

Bing Cherry Juice

Question 6

define Gout

Answer 6

increased Uric Acid in the blood; termed Uricemia

Question 7

what is the cause of gouty arthritis?

Answer 7

Na+ Urate Crystals deposit in joints

Question 8

what is Gout in the big toe termed

Answer 8

Podagra

Question 9

what is the Genetic predisposition for gout?

Answer 9

X-linked recessive gene (90% male sufferers)

Question 10

what foods are high in Purines?

Answer 10

organ meats, aged cheese, alcohol

(beer, wine)

Question 11

what disease is caused by genetic enzyme deficiency of HGPRT?

Answer 11

Lesch-Nyhan Syndrome

Question 12

what are the symptoms of Lesch-Nyhan Syndrome?

Answer 12

Gouty arthritis, mentally challenged, self mutilation (ex. chew finger tips off)

Question 13

what disease is caused by genetic enzyme deficiency of Glucose-6-Phosphatase?

Answer 13

Von Gierke’s Disease

Question 14

what are the symptoms of Von Gierke’s Disease?

Answer 14

Hypoglycemia, gout, glycogen build up