Degradation of Purines (Nucleotide Synthesis) Flashcards
Nucleotide Synthesis
what water-soluble molecule is produced from Purine degradation?
Xanthine
what less water-soluble molecule is produced from Purine degradation?
Uric Acid
what enzyme degrades Purines, and what does it require?
(does the conversion Hypoxanthine –> Xanthine –> Uric Acid)
Xanthine Oxidase; Mo
what drug blocks the enzyme Xanthine Oxidase?
Allopurinol
what natural food acts like Allopurinol?
(blocks enzyme Xanthine Oxidase)
Bing Cherry Juice
define Gout
increased Uric Acid in the blood; termed Uricemia
what is the cause of gouty arthritis?
Na+ Urate Crystals deposit in joints
what is Gout in the big toe termed
Podagra
what is the Genetic predisposition for gout?
X-linked recessive gene (90% male sufferers)
what foods are high in Purines?
organ meats, aged cheese, alcohol
(beer, wine)
what disease is caused by genetic enzyme deficiency of HGPRT?
Lesch-Nyhan Syndrome
what are the symptoms of Lesch-Nyhan Syndrome?
Gouty arthritis, mentally challenged, self mutilation (ex. chew finger tips off)
what disease is caused by genetic enzyme deficiency of Glucose-6-Phosphatase?
Von Gierke’s Disease
what are the symptoms of Von Gierke’s Disease?
Hypoglycemia, gout, glycogen build up