Pulmonary Signs and Symptoms Flashcards
Dyspnea
Definition
A subjective sensation of breathlessness, air hunger, or shortness of breath.
Not a physical exam finding.
Dyspnea
Associated Findings
- Tachypnea
- Labored breathing
- High minute ventilation
- No physical signs
Dyspnea
Physiological Causes
-
↑ Ventilatory requirement
- Exercise, hypoxia, metabolic acidosis
-
↑ Airway resistance
- COPD, asthma, upper airway obstruction
-
↓ Lung compliance
- Interstitial lung disease, pulmonary fibrosis
-
↓ Chest wall compliance
- Kyphoscoliosis
-
Psychogenic dyspnea
- “Hyperventilation syndrome”
- Low CO2 causes sensation that you need to breathe faster
- “Hyperventilation syndrome”
Dyspnea
History
-
Duration of sx
- Chronic vs acute
-
Rate of onset
- Acute (mins-hrs), subacute (days-weeks), chronic (months-yrs)
-
Exposures
- Smoking, occupational, environmental
- Organic dust ⇒ allergic alveolitis
- Inorganic dust ⇒ pulmonary fibrosis
- Smoking, occupational, environmental
Acute Dyspnea
Causes

Subacute Dyspnea
Causes

Chronic Dyspnea
Causes

Exertional Dyspnea
Causes
-
Obstructive lung disease
- Exertion → ↑ RR → ↓ expiratory time
- Obstruction → ↓ expiratory flow
- Trapped air exerts pressure on lungs
-
Interstitial lung disease
- Exertion → ↑ HR
- ↓ Time for O2 to diffuse across diseased alveolar-capillary membrane
- Exercise-induced asthma
- CHF
-
Peripheral vascular disease
- Anaerobic threshold sooner → ↑ CO2 → dyspnea

Exertional Dyspnea
History
- Quantify amount of exertion → distance
- Rate of decline
- Severity
-
Timing/duration of sx
- During or after exercise
-
Associated symptoms
- CP, cough, edema
- Effect of position change
Orthopnea
Definition
Dyspnea in a recumbent position which is relieved by sitting up.
Orthopnea
Causes
-
CHF
- More fluid into the lungs
-
COPD
- Diaphragm works better when sitting up
- Diaphragm weakness
Paroxysmal Nocturnal Dyspnea
Definition
Episodic dyspnea that awakens patient from sleep.
PND
Causes
-
CHF
- Shift of fluid from BLE ⇒ ↑ venous return to the heart ⇒ ↑ fluid in lungs
-
COPD
- Diaphragm works better upright
Platypnea
Definition
Dyspnea in the upright position which is relieved in a recumbent position.
Orthodeoxyplatypnea
Platypnea associated with positional hypoxia.
Platypnea
Causes
-
Right-to-left shunt
- Usually at the lung base
- Sitting up pulls more blood into the lower lung
- Liver disease
Trepopnea
Definition
Dyspnea in one lateral position but not the other.
Trepopnea
Causes
Seen in unilateral lung disease.
Ex. PNA
Good lung down ⇒ gravity improves ventilation and perfusion
Cough
Definition
Reflex initiated by stimulation of irritant airway receptors to expel secretions and irritants.
Cough
Mechanism
- Initial inspiration
- Occlude glottis with vocal cord closure
- Contraction of expiratory muscles against a closed glottis
- Rapid opening of glottis with release of air under pressure
Cough
History
- Smoking hx
-
Duration/onset of cough
- Acute ⇒ < 3 weeks
- Subacute ⇒ 3-8 weeks
- Chronic ⇒ > 8 weeks
-
Position/time of day
- Recumbent cough ⇒ post-nasal drip, CHF, GERD
- Presence/quality of sputum
Sputum
Qualifications
-
Dry cough
- Viral URI, asthma, GERD, post-nasal drip
- Clear frothy sputum ⇒ normal saliva
- Pink frothy sputum ⇒ pulmonary edema
-
Mucoid sputum
- Lower airway secretions, chronic bronchitis, asthma
-
Purulent sputum
- Infection ⇒ PNA, bronchitis, bronchiectasis
Acute Cough
Causes

Subacute Cough
Causes

Chronic Cough
Causes

Chronic Cough
Management
CXR ⇒ r/o serious pathology
History and physical may guide approach:
-
Smoker
- CXR, PFT, smoking cessation
-
Post-nasal drip
- Trial antihistamine/decongestant, allergy testing, sinus CT
-
Reflux or cough worse with meals/recumbency
- Trial H2 blocker or PPI, 24 hour pH probe
-
Wheezy dry cough precipitated by asthma triggers
- PFT, bronchodilator trial, methacholine challenge
-
Prolonged cough following URI
- Trial bronchodilator ± inhaled steroid
-
History of ACEi or β-blocker
- Trial of drug cessation
Hemoptysis
Definition
Expectoration of blood.
Hemoptysis
Look Alikes
-
Epistaxis ⇒ blood in nares and/or nasopharynx
- Blood may be inhaled then expectorated
-
Hematemesis ⇒ vomiting blood
- Acidic pH
- Food particles
- Dark blood
- Epigastric complaints
Hemoptysis
History
- Bright red and frothy sputum
- Associated cough
- Alkaline pH
- Contains alveolar macrophages
- Pt can often ID source and location
Hemoptysis
Causes
-
Common
-
Infectious
- TB, PNA, bronchitis, abscess
- Bronchogenic cancer
- PE with infarction
- Bronchiectasis
-
Infectious
-
Unusual
-
Occupational exposures
- Trimellite anhydride ⇒ heated metal surfaces sprayed with epoxy paints
- Isocyanates
-
Catamenial hemoptysis ⇒ pulmonary endometriosis
- Pieces of endometrium ends up in the lungs
- Undergoes cyclical bleeding similar to uterus
- Free base cocaine
- Vasculitis
- Trauma
-
Occupational exposures
Bronchiectasis
Definition
Abnormal dilation of bronchi with destruction of elastic/muscular components of the bronchial wall.
Hemoptysis
Management
-
Quantify hemoptysis
-
Massive hemoptysis: > 600 ml/24 hrs
- Position bleeding side down
- May worsen bleeding but protects good lung
- Position bleeding side down
-
Massive hemoptysis: > 600 ml/24 hrs
- CBC, platelets, PT/PTT
- Urinalysis ⇒ check for RBC/casts
- Start codeine 15-30 mg q4h ⇒ suppress cough
- CXR
-
Sputum culture and sensitivity
- AFB (Acid fast bacillus) ⇒ check for TB
- Isolation if suspected
- AFB (Acid fast bacillus) ⇒ check for TB
- Start broad spectrum abx
- Avoid chest percussion
Hemoptysis
Evaluation
- Acute management
- Bronchoscopy ⇒ localize bleeding
- Vasculitis work-up if suspected
- Collagen vascular panel
- ANCA (Anti-neutrophil cytoplasmic autoantibody)
Pleuritic Chest Pain
Definition
Sharp knife-like chest pain associated with coughing or breathing.
Pleuritic CP
Mechanism
-
Stimulation of pain fibers in parietal pleura
- Visceral pleura and lungs have no pain fibers
-
Caused by inflammation or trauma involving any thoracic structure affected by respiratory movement
- Ribs, cartilage, muscles, nerves, pleura, pericardium
Pleuritic CP
History
- Duration and onset
- Severity
- Location
- Associated sx
- Fever, SOB, hemoptysis
- Smoking hx
Pleuritic CP
Causes
-
Infection
- Associated w/ fever, cough, purulent sputum
-
Pulmonary infarction
- Acute-onset, dyspnea, hemoptysis
-
Pleurisy ⇒ viral infection of the pleura
- Acute-onset, often with other viral sx
-
Malignancy
- Usually subacute or chronic
- Pleuritis ⇒ associated with collagen vascular disease
-
Pneumothorax ⇒ collapse of lung d/t air in the pleural space
- Acute-onset, dyspnea, ↓ breath sounds with hyperinflation of affected side
-
MSK pain
- Mostly acute-onset
- Rib fx, costochondritis, myositis, nerve pain
Pleuritic CP
Evaluation
- CXR / rib films
- Cultures and viral serologic studies
- Collagen vascular disease work-up
- Possible work-up for PE
Wheezing
Definition
Continuous adventitous breath sounds.
- Vibration of air through narrowed airways
- Most prominent during expiration
Wheezing
Characteristics
-
Pitch
- High pitch ⇒ stiff, narrow obstruction
- Low pitch ⇒ large, floppy airways
- Complexity ⇒ monophonic vs polyphonic
- Duration ⇒ short vs long
- Timing ⇒ inspiratory vs expiratory
Wheezing
History
- Smoking hx
- Duration and onset
- Triggers / exposures
- Severity
- Location
- Focal or diffuse
- Upper airway
Wheezing
Causes
- Asthma
- COPD
-
Fixed airway obstruction
- FB aspiration
- Upper airway obstruction or tumor
-
CHF
- “Cardiac asthma” ⇒ caused by edema of the airways
- Acute inhalation of irritant gas
- “Laryngeal asthma” ⇒ paradoxical motion of the vocal cords
Wheezing
Evaluation
- Complete hx
- CXR
- PFTs
- Evaluation for CHF
Stridor
Definition
Loud continuous inspiratory breath sounds.
- Often heard without a stethoscope
- Usually loudest in the neck
Stridor
Causes
Usually a sign of an extra-thoracic upper airway obstruction:
- Goiter
- Vocal cord polyp
- Upper airway tumor
- Croup
Clubbing
Definition
Painless bulbous enlargement of the distal fingers ± toes, with softening of the nail bed.

Clubbing
Diagnosis
-
Check nail bed for sponginess
- Occurs before loss of angle
-
Evaluate angle between nail and adjacent dorsal surface of the distal phalynx
- Normal angle ⇒ diamond space between thumbs

Clubbing
Pulmonary Etiologies
- Lung cancer
- Chronic infection
- TB, bronchiectasis, lung abscess
- Idiopathic pulmonary fibrosis
- Cystic fibrosis
- Alveolar proteinosis
***COPD does not cause clubbing, must look for other causes in a smoker.