Pulmonary Pathology

Question 1

What is the new name for Hamman-Rich Syndrome?

Answer 1

AIP / ARDS

Question 2

What gene increases the risk for UIP? And by how much?

Answer 2

MUC5B gene, by 30%

Question 3

What cell markers are present in Langerhan’s Cell Histiocytosis?

Answer 3

S-100

CD-1a

Question 4

What 2 ILDs with granulomas?

Answer 4

• HP (acute): noncaseating, sparse. Bronchiolocentric interstitial infiltrate.
• Sarcoid - noncaseating along bronchovascular bundles & intralobular septa. No interstitial infiltrate.

Question 5

PFT findings in subacute HP?

Answer 5

Restrictive

Question 6

BAL pattern with subacute HP?

Answer 6

Lymphocytic

Question 7

Chronic HP BAL?

Answer 7

loss of lymphocytosis

Question 8

Chronic HP anatomic location?

Answer 8

upper lobe

Question 9

Which stages of HP are nonfibrotic? Fibrotic?

Answer 9

Acute / subacute = nonfibrotic

Chronic = fibrotic

Question 10

What are the biopsy findings of LAM?

Answer 10

smooth muscle cells associated with cysts

Question 11

What is the cellular marker for LAM?

Answer 11

HMB-45, CD1a, S-100

Question 12

Tuberous Sclerosis is associated with what pulmonary diseae?

Answer 12

LAM

Question 13

CT findings of Pulmonary Alveolar Proteinosis?

Answer 13

Crazy Paving

Question 14

Serologic marker for primary Pulmonary Alveolar Proteinosis?

Answer 14

Anti-GMCSF antibodies

Question 15

What is Loeffler’s Syndrome?

Answer 15

Eosinophilic accumulation in the lungs in response to parasitic infection, most commonly Strongyloides or Ascaris

Question 16

BAL Eosinophil count for acute eosinophilic pneumonia?

Answer 16

> 25%

Question 17

Treatment of acute eosinophilic pneumonia?

Answer 17

steroids