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ABIM Pulmonary > Eosinophilic Lung Disease > Flashcards

Eosinophilic Lung Disease Flashcards

1
Q

Lab value for ABPA?

A

IgE > 1,000

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2
Q

Buzzword: “Finger in Glove” on CT. What disease?

A

ABPA or CF (but really any dilated bronchus due to obstruction, usually mucous)

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3
Q

Treatment for ABPA?

A

Steroids. Itraconazole not required. Treat underlying Asthma.

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4
Q

Treatment for Loeffler Syndrome?

A

None needed. Self-limited.

-Pulmonary Eosinophilia due to parasites, Rx, idiopathic.

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5
Q

Symptoms of Tropical Pulmonary Eosinophilia?

A

cough at night (due to migration of parasite)

+/- refractory asthma

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6
Q

Causative agent of Tropical Pulmonary Eosinophilia?

A

Wucheria Bancrofti

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7
Q

Treatment for Tropical Pulmonary Eosinophilia?

A

Anti-parasitic’s

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8
Q

Most common drugs to cause pulmonary eosinophilia?

A

Antibiotics (usu daptomycin)
NSAIDs
Recreational drugs
Macrobic (w/ eosinophilic pleural effusion)

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9
Q

BAL findings in Acute Eosinophilic Pneumonia?

A 
Eosinophils >25%
IgE
VEGF
IL-18
IL-5
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10
Q

What must be excluded to diagnose Acute Eosinophilic Pneumonia?

A

parasitic infection, drugs, asthma

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11
Q

Treatment and prognosis for Acute Eosinophilic Pneumonia?

A
  • Prednisone for 2-8 weeks

- Good prognosis. Does not relapse after prednisone course.

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12
Q

Biopsy findings in Acute Eosinophilic Pneumonia?

A

Diffuse alveolar damage + eosinophils in bronchial walls and intersitium.

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13
Q

BAL findings in Chronic Eosinophilic Pneumonia?

A

Eosinophils > 30%

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14
Q

Buzzword: “Photo-negative pulmonary edema”. What disease?

A

Chronic Eosinophilic Pneumonia

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15
Q

Treatment & prognosis in Chronic Eosinophilic Pneumonia?

A

Prednisone for 3-6 months. Relapses in 50% after taper.

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16
Q

Diagnosic criteria for idiopathic hypereosinophilc syndrome?

A

Eosinophils > 1500

17
Q

Treatment options for Idiopathic Hypereosinophilic Syndrome?

A 
Steroids
IFN-alpha
Chemo
Hydroxyurea
Imatinib
Mepolizumab (Anti-IL-5)
18
Q

Mononeuritis Multiplex in eosinophilic lung disease. What underlying condition?

A

EGPA

19
Q

Diagnostic criteria for EGPA?

A

4 of 6:

  • Asthma
  • Peripheral Eosinophilia > 10% or 1500
  • Paranasal sinus abnormalities
  • Mono- or poly-neuropathy
  • Migratory Pulmonary Opacities
  • Extravascular eosinophils on biopsy
20
Q

Serologic positivity in EGPA?

A

P-ANCA / MPO

21
Q

Treatment for EGPA?

A
  • Steroids
  • Azathioprine
  • Methotrexate
  • Mepolizumab
  • Severe: Rituxan, cyclophosphamide or plasmapharesis

ABIM Pulmonary (37 decks)

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