Pulmonary Med Chem: COPD Flashcards
Chronic lower respiratory diseases are the ___ leading cause of death in the U.S.
4th
Chronic obstructive pulmonary disease (COPD) is a/an (reversible/irreversible) disease of the airway
Irreversible
Characterizations of COPD
Obstruction of airflow, bronchoconstriction, mucosal edema, and mucosal hypersecretion
Which clinical form of COPD is bronchitis predominant? Emphysema predominant?
Type A: Pink Puffer - Emphysema predominant
Type B: Blue Bloater - Bronchitis predominant
Genetic susceptibility for COPD involves a deficiency of what?
Alpha 1 anti-trypsin
What are the two main receptors targeted in the treatment of COPD?
Beta 2 receptors and muscarinic M3 receptors
Which of the following treatment regimens is not used to treat COPD?
a. ICS and LABA
b. LAMA monotherapy
c. LAMA and LABA
d. ICS monotherapy
d. ICS monotherapy
Salmeterol is a ______ agonist
Partial
Formoterol is a _______ agonist
Full
True or false: Formoterol is more lipophilic than salmeterol
False. Less lipophilic
Arformoterol is a _______ agonist and is the (R/S) enantiomer of formoterol
Full, R
Arformoterol is _______ as potent as racemic formoterol
a. twice
b. three times
c. four times
a. twice
Indacaterol and olodaterol are both _________ agonists and ________ beta 2 agonists
Nearly full. ultra long acting
What is the difference between the dosage forms of indacaterol and olodaterol?
Indacaterol comes as a dry powder inhaler while olodaterol comes as a mist
Which enantiomer of olodaterol is the active component?
R enantiomer
