GI Disorders N/V

Question 1

What diagnostic test is used to diagnose nausea and vomiting?

Answer 1

None

Question 2

When is prophylactic treatment normally used for N/V?

Answer 2

. Pre-op
. Chemotherapy

Question 3

5HT3 receptor antagonist MOA and adverse effects

Answer 3

MOA - block serotonin receptors
AE - QTc prolongation, serotonin syndrome possibly

Question 4

What is the most commonly seen 5HT3 receptor antagonist used for N/V?

Answer 4

Ondansetron

Question 5

Which medication is gold standard treatment for post operative N/V?

Answer 5

Ondansetron

Question 6

Ondansetron off label uses

Answer 6

. Gastroparesis
. Pregnancy associated N/V
. Vertigo

Question 7

Which 5HT3 antagonist has lowest risk of QTc prolongation?

Answer 7

Palonosetron

Question 8

Which 5HT3 antagonist comes as a transdermal patch?

Answer 8

Granisetron

Question 9

Triad associated with adverse events of serotonin syndrome

Answer 9

. Altered mental status
. Abnormalities of neuromuscular (rigidity, reflexes)
. Autonomic hyperactivity

Question 10

What are the 3 classes of dopamine 2 receptor antagonists?

Answer 10

Phenothiazines, butyrophenones, and metoclopramide

Question 11

Black box warning for droperidol

Answer 11

QTc prolongation

Question 12

Metoclopramide MOAs

Answer 12

. Dopamine 2 receptor antagonist in CTZ
. Stimulates GI activity (prokinetic)

Question 13

Metoclopramide black box warning

Answer 13

Tardive dyskinesia

Question 14

Substance P/ Neurokinin 1 receptor antagonist MOA

Answer 14

Inhibits the substance P/ Neurokinin 1 receptor and augments activity of serotonin receptor antagonists and corticoids

Question 15

Substance P/ Neurokinin 1 receptor antagonist indication

Answer 15

Chemotherapy induced N/V

Question 16

Corticosteroids that can be used for N/V?

Answer 16

. Dexamethasone
. Methylprednisolone

Question 17

Site of action for antihistamines for indication of N/V

Answer 17

Vestibular nuclei

Question 18

Which antihistamine for N/V has least occurrence of drowsiness?

Answer 18

Meclizine

Question 19

Scopolamine drug classification

Answer 19

Anticholinergic

Question 20

Active ingredient in children’s formulation of Pepto Bismol?

Answer 20

Calcium carbonate

Question 21

Active ingredient in adult formulation of Pepto Bismol?

Answer 21

Bismuth subsalicylate

Question 22

Cautions with pepto bismol

Answer 22

Increased bleeding risk. Use with caution in patients on anticoagulants

Question 23

Ginger has a major drug interaction with which medication?

Answer 23

Warfarin