Dyslipidemia Flashcards
What is the rate limiting step of the formation of cholesterol?
The conversion of β -hydroxyl-β -methylglutaryl
coenzyme A (HMG-CoA) to mevalonic acid
Which lipids that serve as an important source of stored energy in adipose tissue?
Triglycerides
What is the most common type of heart disease in the U.S?
Coronary artery disease
True or false: HDL-C is inversely related to CHD risk
False
What test is often used to diagnose dyslipidemia?
Fasting lipid panel
What is the Friedewald equation? What is it used for?
. LDL = TC – HDL – (TG/5)
. Calculate LDL
What is the main protein component of LDL?
Apo B
In what population should FLPs be routinely checked?
a. 20-50
b. 30-50
c. 20+
d. 30+
c. 20+
How often should a FLP be taken?
At least once every 5 years
True or false: The Framingham 10 year CHD risk tool is a fully comprehensive tool currently used to assess ASCVD risk
False. Currently the 10 year ASCVD risk tool, which is more comprehensive than the Framingham
Which of the following is an appropriate goal of dyslipidemia therapy?
a. Raise TC and lower LDL
b. Raise TC and LDL
c. Lower TC and raise LDL
d. Lower TC and LDL
d. Lower TC and LDL
Select all treatments that are currently more recommended according to current guidelines?
▪HMG-CoA Reductase Inhibitors (Statins)
▪Cholesterol Absorption Inhibitor
▪Niacin
▪Apo B Antisense Oligonucleotides
▪Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors
▪Microsomal Triglyceride Protein Inhibitors
▪HMG-CoA Reductase Inhibitors (Statins)
▪Cholesterol Absorption Inhibitor
▪Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors
Which HMG-CoA reductase inhibitors are prodrugs?
Lovastatin and simvastatin
What is the most common adverse effect of HMG-CoA reductase inhibitors?
Myalgia (muscle pain)
Which statin drug and at what dose is highly associated with rhabdomyolysis?
Simvastatin 80mg