Pulmonary II - Chronic Bronchitis and Emphysema Flashcards
General features of chronic bronchitis - what does a typical patient present like?
patient with persistent cough + sputum production for at least 3 mo in at least 2 consecutive years
simple chronic bronchitis
productive cough but no evidence of airway obstruction
chronic asthmatic bronchitis
intermittent bronchospasm, wheezing - hyper-reactive airways
obstructive chronic bronchitis (heavy smokers)
physiologic obstruction +emphysema
Pathogenesis of chronic bronchitis
–what are the two important factors?
two factors:
1) chronic irritation by inhaled substances,
2) microbiologic infections
4-10X more common in smokers
hypersecretion of mucus with mucous plugging
- –secondary obstruction to air flow
- –secondary infection
Chronic damage to the epithelium that occurs with chronic bronchitis can lead to …
metaplasia
- –large airways – squamous metaplasia
- –small airways – goblet cell metaplasia
Increased mucus production seen with chronic bronchitis
- -associated with …
- -what accompanying alterations are there?
associated with hypertrophy of submucosal glands in
trachea and bronchi
accompanying alterations small airways (2-3 mm)
–marked increase in goblet cells of small airways; mucus plugging of the lumen
–inflammatory infiltration
–fibrosis of the bronchiolar wall
–mucosal secretion is under autonomic (vagal) control;
?hypersecretion caused by neurohormonal pathways (also bronchoconstriction)
Pathogenesis of chronic bronchitis
- -causes
- -can coexist with
- -what is the role of infection
smoking and irritants also cause bronchiolitis - early
and relatively mild airflow obstruction
when bronchitis is accompanied by moderate to severe airflow obstruction, coexistent emphysema is the dominant lesion
role of infection is secondary
–not responsible for initiation of chronic bronchitis
–significant in maintaining bronchitis; acute
exacerbations
–cigarette smoke interferes with ciliary action
–also inhibits bronchial and alveolar leukocytes
Gross features of chronic bronchitis
hyperemia, swelling, bogginess of mucous
membranes
excessive mucinous to mucopurulent secretions
heavy casts of secretions and pus
Morphology of chronic bronchitis involving the large airways
enlargement of mucus-secreting glands of the trachea and bronchi (Reid Index)
- –ratio of the thickness of mucosal glands to the thickness of wall between the epithelium and the cartilage; normally < 0.4
- –increased in proportion to severity and duration of the disease
squamous metaplasia and dysplasia of large airways
Morphology of chronic bronchitis involving the small airways
marked narrowing of bronchioles - goblet cell metaplasia,mucous plugging, inflammation, and fibrosis
most severe cases - bronchiolitis obliterans
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