HEPATOBILIARY Flashcards

1
Q

When Jaundiced in hepatitis, what is liver ALT levels?

A

super high in the 1000s

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2
Q

what causes high ALT?

A

hepatocyte membrane damage

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3
Q

When do you get Mallory bodies?

A

alcoholic hepatitis

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4
Q

when do you get centrilobular necrosis?

A

paracetomol toxicity

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5
Q

what is a Councilman body?

A

hepatocyte undergoing apoptosis

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6
Q

2 giveaways of alcoholic hepatitis?

A

Mallory bodies

Neutrophils

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7
Q

Cholestasis histologically see?

A

yellow brown dots (bile plug) in dilated biliary canaliculi

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8
Q

what is a hallmark feature of acute viral hepatitis B?

A

APOPTOSIS and ground glass hepatocytes

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9
Q

what happens to portal tracts in chronic hepatitis C? 4 things

A
  1. lymphocytes infiltration
  2. Fatty change
  3. interface hepatitis
  4. bridging fibrosis
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10
Q

Two examples of Non-alcoholic fatty liver disease?

A

DM and CHF

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11
Q

What is steatosis?

A
just fat (triglyceride) in the liver
fatty liver
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12
Q

3 types of steatosis are?

A

macrovesicular/large droplet
microvesicular/small droplet
Mixed type

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13
Q

Liver failure skin findings

A

Erythema, spider angioma, jaundice

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14
Q

Rusty smell in liver failure

A

mercaptans

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15
Q

Renal failure in liver failure

A

Hepatorenal syndrome

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16
Q

Hemochromatosis- organ involvement

A

liver, joint, skin, pancreas, heart

17
Q

Fulminant hepatitis- cause

A

Drug, superinfection, pregnancy, Wilson,

18
Q

Causes of alcoholic steatosis

A

decreased apoprotein decreased lipoprotein secretion, , increased fat biosynthesis, increased peripheral catabolism of fat