CNS Flashcards
cells involved in JC virus infection?
oligodendrocyte
mech of PML (progressive multifocal leukoencephalopathy)?
- demyelination of CNS due to destruction of oligodendrocytes - associated with JC virus - rapidly progressive
2 structures from neural crest?
- PNS neurons 2. Schwann cells
structure from mesoderm?
microglia
what pathology is associated with hyperphosphorylated tau protein?
Alzheimer
what pathology is associated with silver staining spherical tau protein with an aggressive change in behavior?
Frontotemporal dementia (Pick’s dz)
what path is associated with alpha synuclein defect with visual hallucination?
Lewy body dementia
is ACh increased or decreased in Alzheimer?
decreased
what is the cause for communicating hydrocephalus?
decreased CSF absorption by arachnoid granulations
what 2 structures make CSF?
- ependymal cells 2. choroid plexus
what condition is associated with arachnoid scarring post-pyogenic meningitis?
communicating hydrocephalus
what is normal pressure hydrocephalus?
- affects elderly 2. CSF pressue elevated only episodically 3. no increased subarachnoid space volume 4. expansion of ventricles –> distorts fibers of corona radiata
what is the mech of clinical symptoms in normal pressure hydrocephalus?
expansion of ventricles –> distorts fibers of corona radiata leading to urinary incontinence, ataxia, cognitive dysfunction
mechanism of ex vacuo hydrocephalous
the appearance of inc CSF due to decreased brain tissue is seen in Alzheimer diseases etc
is ICP increased or decreased in communicating hydrocephalus?
increased
