MSK Pathology Flashcards
Achondroplasia is a defect in
cartilage = failure of long bone growth
Specific achondroplasia mutation
AD, Activating mutation in FGF23 –> FGF23 inhibits chondrocytes
Achondroplasia presentation
Short arms and legs (endochondral ossificaiton), normal torso and head (intramembranous ossification is unaffected)
Osteogenesis imperfecta defect
AD mutation resulting in defective Type I collagen synthesis
The classic triad of OI- type 3
Multiple Fractures in strange places Blue sclera Hearing loss (inner ear bones Fx)
Examples of type 1 collagen
tendons, ligaments, the endomysium of myofibrils, interstitial stroma, the organic part of the bone, the dermis, the dentin, and organ capsules.
Labs for Osteopetrosis
Pancytopenia
2 Neuro complications of osteopetrosis
Vision/hearing impariment due to compression of nerves by foramina
Pathogenesis of osteopetrosis. Mechanism?
Lack of osteoclast function
Rickets/Osteomalacia defect
Excessive unmineralized osteoid; bad quality bone
MCC of Rickets/OM
Vitamin D deficiency
Osteomalacia lab values (Ca, Phos, PTH, Alk Phos)
Low Ca and Phos (low vitD) High PTH High Alk Phos (osteoblasts are driven by PTH. They are still working fine)
Osteoporosis is a reduction in
Trabecular bone mass (endosteal and periosteal resorption)
3 major Risk factors for osteoporosis
weight bearing exercise, menopause, Age
Effect of estrogen on bone development
Estrogen inhibits RANK, Loss of estrogen after menopause = more active osteoclasts
2 fracture-related complications of osteoporosis
Vertebral compression Fx Hip Fx
besides vertebral fractures which vertebral complications do osteoporosis pts have
Kyphosis and decreased height
Osteoporosis labs (Ca, Phos, PTH, alk phos)
All normal! Normal labs in the face of bone pain distinguishes this from osteomalacia
Paget disease of bone underlying problem
Imbalance b/w osteoblasts and osteoclasts (too much), viral infection, genetics
paget disease progression
Overactive osteoclasts –> osteoclasts start burning out –> osteoblasts activate –> lay down poor structure bone
A 58-year-old male patient reported to the dental hospital with a complaint of difficulty in vision.
History revealed that there were swellings in the skull bones, which started 6 years back. All swellings gradually increased in size. X-Ray skull attached. Diagnosis?
Pagets
4 classic SSx of paget’s disease of bone
Bone Pain Hearing loss/ Vision changes Increasing hat size Coarsening of facial features
Characteristic lab abnormality in paget’s disease
Isolated elevated ALk Phos with everything else normal
histology of paget’s
mosaic pattern of lamellar bone
2 major complications of paget disease
High output heart failure, Osteosarcoma
location of hematogenous osteomyelitis in kids (< 2 years) vs adults
Kids = epiphysis, Adults = metaphysis
MCC (most common cause) of osteomyelitis overall
S. aureus
MCC of osteomyelitis in diabetic or IV drug user
Psudomonas
MCC of osteomyelitis in sickel cell
salmonella typhi
Xray appearance of osteomyelitis
Lytic bone lesion surrounded by sclerosis (lytic lesion = sequstrum) (sclerosis = involurcrum)
The diagnosis is strongly suggested by the characteristic radiographic findings of a lytic focus of bone destruction surrounded by a zone of sclerosis.
Osteoma association
Gardner syndrome (FAP, fibromatosis, osteomas)
Osteoid osteoma is a tumor of
Osteoblasts
Gross appearance of osteoid osteoma
Tumor of osteoblasts surrounded by a ring of reactive bone
Osteoid osteoma imaging
Bony mass with a radiolucent core (osteioid from the osteoblasts)
Classic location of osteoid osteoma
Cortex of long bones
The classic presentation of osteoid osteoma
Humerus or femur pain that resolves with aspirin
Osteoblastoma location
Everything is the same as an ostoid osteoma, but it is located in the vertebra
Osteoblastoma presentation
Back pain that does not respond to aspirin (r/o osteoid osteoma)
diagnosis and location of origin
Osteochondroma arises from the lateral projection of the epiphyseal plate
Structure of osteochondroma
Bone with an overlying cartilage cap
Giant cell tumor location
Epiphysis of long bones. ONLY TUMOR IN THE EPIPHYSIS
Giant cell tumor is a proliferation of
Stromal cells
Xray of Giant cell tumor
“bubble” appearance of the epiphysis
osteosarcoma AKA
osteogenic sarcoma
Osteogenic sarcoma is a proliferation of
osteoblasts
primary osteosarcoma location
METAPHYSIS of long bones (unlike giant cell tumors)