Puberty And Menopause Flashcards

1
Q

Define thelarche

A

Development of breasts

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2
Q

Define pubarche

A

Development of pubic and axillary hair

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3
Q

Define menarche

A

First menstrual period

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4
Q

Define adrenarche

A

Onset of an increase in the secretion of androgens

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5
Q

Define puberty

A

Stage of development when sexual maturation and growth are complete and result in the ability to reproduce

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6
Q

What are the events of puberty?

A

Accelerate somatic growth
Maturation of primary sexual characteristics
Appearance of secondary sexual characteristics
Menstruation/spermatogenesis begins

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7
Q

What is the difference in the growth spurt between the sexes?

A
Females = starts earlier but is shorter
Males = starts later but is longer and faster
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8
Q

What marks the end of growth spurt?

A

Closure of epiphyseal growth plates in bones

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9
Q

What is the critical weight that it is unlikely puberty will start before?

A

47 kg

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10
Q

Describe what happens to the HPG axis in puberty

A

Gradual activation of GnRH
Increased frequency and amplitude of LH pulses
Gonadtropins stimulate sex steroid secretion
Extragonadal hormone changes

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11
Q

Which area in brain signals puberty?

A

Arcuate area

Releases kiss peptide

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12
Q

Give some effects of increased GH secretion

A
Increases TSH 
Increases metabolic rate 
Promotes tissue growth 
Increases androgens 
Growth spurt
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13
Q

What are the first phenotypic changes in males and females?

A
Breast development (females)
Testicular enlargement (males)
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14
Q

At what age in males does LH and FSH start to rise?

A

~10 years

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15
Q

What is the approximate age range of puberty in girls?

A

9 - 13 years

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16
Q

What is the approximate age range of puberty in boys?

A

10 - 14 years

17
Q

What is the average age of start of puberty in boys and girls?

A
Boys = 12.5
Girls = 11.5
18
Q

What is the average duration of puberty in boys and girls?

A
Boys = 3.2 years
Girls = 2.4 years
19
Q

What is precocious puberty?

A

Occurring younger, more common occurrence in girls
Girls < 8 years
Boys < 9 years
Majority have unknown cause

20
Q

Give some known causes of precocious puberty

A

Gonadotropin dependent: Hormone secreting tumours, CNS trauma, congenital disorders
Gonadotropin independent: pineal tumours, meningitis, congenital adrenal hyperplasia, testotoxicosis

21
Q

What is delayed puberty?

A

Initial physical changes are not present by age 13 in girls or age 14 in boys

22
Q

Give some causes of delayed puberty

A

Gonadal failure - Turner’s, post-chemo, autoimmune

Gonadal insufficiency - congenital, hypothalamic/pituitary lesions

23
Q

Describe Turner syndrome

A

Karyotype 45, X
Short stature, gonadal dysgenesis, skeletal abnormalities, cardiac and kidney malformation
No mental defect
Give growth hormone and sex hormone substitutions

24
Q

What are the 7 common problems with menopause?

A
Itchy 
Twitch 
Sweaty 
Sleepy 
Bloated 
Moody 
Forgetful
25
Q

Describe pre-menopause

A

Typically from age 40 years
Follicular phase shortens
Ovulation is early or absent - less oestrogen, more LH and FSH
Reduced fertility

26
Q

Describe menopause

A
Cessation of menstrual cycle 
Absent for 12 months = into menopause 
Average age 49-50 years 
No more follicles to develop - oestrogen levels fall dramatically 
FSH and LH rise 
No inhibin
27
Q

What are the effects of menopause?

A

Hot flushes - vascular changes - often at night
Transient rises in skin temp and flushing
Relieved by oestrogen treatment

28
Q

What are the effects of menopause on bone?

A

Bone mass reduces by 2.5% per year
Reduced oestrogen - enhanced osteoclasts therefore more bone resorption
Type 1 osteoporosis

29
Q

How does hormone replacement therapy work?

A

Relives Sx of menopause and can improve well being
Orally or topically
Give slowly decreasing doses
Can limit osteoporosis