Puberty Flashcards
What are the important sex hormones in females?
Oestradiol
Progesterone
Adrenal androgen precursors
What are the important sex hormones in males?
Testosterone
DHT
Adrenal androgens
Oestradiol
What is gonadarche?
Activation of gonads by FSH and LH
What is thelarche?
Appearance of breast tissue
What causes pubarche?
Androgens
What is ‘mini-puberty’ of infancy?
Activation of HPG axis during neonatal period
What are the Tanner stages?
Standards for rating pubertal changes
How is precocious puberty defined?
Boys - before age 9
Girls - before age 8
What is the first sign of puberty for boys?
Testes enlargement
What is the first sign of puberty for girls?
Breast budding
Which sex is delayed puberty more common in?
Boys
vv for early in girls
What is true central precocious puberty? (TCPP)
Right order of pubertal events but happening early
Gonadotropin dependent
What is peripheral precocity?
Wrong order of puberty
Gonadotropin independent
What is McCune Albright syndrome?
Triad of symptoms:
- Peripheral precocious puberty
- Irregular cafe au lait spots
- Fibrous dysplasia of bone
How is early puberty treated?
if true puberty - blocked with DNRH agonists
if gonadotrophin independent, anti-androgens