puberty

Question 1

GnRH neurons start in the _______ and migrate through the _________ to final destination

Answer 1

GnRH neurons start in the nose and migrate through the forebrain to final destination

Question 2

GnRH neurons are already mature at birth

Answer 2

yep

Question 3

follicular GnRH pulsatility

Answer 3

low amplitude and high frequency

Question 4

luteal GnRH pulsatility

Answer 4

high amplitude and low frequency

Question 5

GnRH secretion is governed by ________

Answer 5

kisspeptin

Question 6

The secretion of both LH and FSH sharply decline as GnRH secretion is changed from pulsatile to ________, but restoring pulsatile secretion of GnRH rapidly restores secretion of both hormones

Answer 6

continuous

Question 7

process of puberty takes __years

Answer 7

4

Question 8

_______ classification of sexual maturity commonly used

Answer 8

Tanner

Question 9

Tanner developed a scale in 1962 that divides the pubertal changes (SMR’s) into 5 classes based on

Answer 9

• Pubic hair* and breasts in females

- Pubic hair* and genitalia in males

Question 10

Adrenarche

Answer 10

At age 6 to 8 years increase in production of androgens in the adrenal glands

Question 11

By___ years most young women have completed puberty, the growth rate slows, there is pubic and body hair, a rounded and curved figure because of widened pelvis, hips and breasts

Answer 11

16

Question 12

First somatic sign

Answer 12

growth spurt (lasts 24-36 months) due to growth hormone and sex steroids

Question 13

adipose changes

Answer 13

increase in girls and decrease in boys

Question 14

brain matures at

Answer 14

25

Question 15

negative feedback system before puberty is

Answer 15

very sensitive thus less estrogen is needed to activate system

Question 16

(produced largely by adipocytes) is one factor that affects maturation of GnRH pulse generator and probably is associated with the initiation of puberty

Answer 16

Leptin

Question 17

Mechanisms initiating adrenarche are NOT associated with the mechanisms initiating gonadarche

Answer 17

yep

Question 18

adrenarche occurs despite absence of gonadarche

genetic condition where the primary symptom is a failure to start puberty or a failure to fully complete puberty. It occurs in both males and females and has the additional symptoms of hypogonadism and almost invariably infertility.

Answer 18

Kallman’s syndrome:

Question 19

gonadarche occurs despite absence of adrenarche

Answer 19

Addison’s Disease:

Question 20

gonadarche precedes adrenarche

Answer 20

Precocious Puberty: