PSYCHIATRY Flashcards

1
Q

Features of PTSD?

A

1 month of…
Re-experiencing - flashbacks, nightmares, repetitive/distressing intrusive images
Avoidance - avoiding people, situations or circumstances associated with the event
Hyperarousal - hypervigilance for threat, exaggerated startle response, sleep problems, irritability, difficulty concentrating
Emotional numbing - lack of ability to experience feelings, feeling detached

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2
Q

When does acute stress disorder occur?

A

Within the first 4 weeks after a person has been espoused to a traumatic event

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3
Q

Which foods should be avoided when on MAOI? why?

A

Tyramine containing foods e.g. cheese, marmite, broad beans, oxo, bovril, pickled herring
Can cause hypertensive reactions!

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4
Q

Factors suggesting pseudodementia?

A

Short history & rapid onset
Biological symptoms e.g. weight loss, sleep disturbance
Pt worrying about their bad memory
Reluctant to take tests and disappointed with the results
Global memory loss rather than recent memory loss

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5
Q

Features of borderline personality disorder?

A

Efforts to avoid real or imagined abandonment
Unstable interpersonal relationships which alternate between idealization and devaluation
Unstable self image
Impulsivity in potentially self damaging area (e.g. Spending, sex, substance abuse)
Recurrent suicidal behaviour and self-harm
Affective instability
Chronic feelings of emptiness
Difficulty controlling temper
Quasi psychotic thoughts - non-bizarre short-lived hallucinations/delusions

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6
Q

Features of antisocial personality disorder?

A

Failure to conform to social norms e.g. laws
Deception: repeated lying, using aliases, conning others
Impulsiveness
Irritability and aggressiveness -> repeated physical fights
Reckless disregard for safety of self or others
Consistent irresponsibility -> failure to sustain work/finance obligations
Lack of remorse

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7
Q

Features of paranoid personality disorder?

A

Hypersensitivity and an unforgiving attitude when insulted
Unwarranted tendency to questions the loyalty of friends
Reluctance to confide in others
Preoccupation with conspirational beliefs and hidden meaning
Unwarranted tendency to perceive attacks on their character

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8
Q

Features of schizoid personality disorder?

A

Indifference to praise and criticism
Preference for solitary activities
Lack of interest in sexual interactions
Lack of desire for companionship
Emotional coldness
Few interests
Few friends or confidants other than family

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9
Q

Features of schizotypal personality disorder?

A

Ideas of reference (differ from delusions in that some insight is retained)
Odd beliefs and magical thinking
Unusual perceptual disturbances
Paranoid ideation and suspiciousness
Odd, eccentric behaviour
Lack of close friends other than family members
Inappropriate affect
Odd speech without being incoherent

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10
Q

Features of histrionic personality disorder?

A

Inappropriate sexual seductiveness
Need to be the centre of attention
Rapidly shifting and shallow expression of emotions
Suggestibility
Physical appearance used for attention seeking purposes
Impressionistic speech lacking detail
Self dramatization
Relationships considered to be more intimate than they are

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11
Q

Features of narcissistic personality disorder?

A

Grandiose sense of self importance
Preoccupation with fantasies of unlimited success, power, or beauty
Sense of entitlement
Taking advantage of others to achieve own needs
Lack of empathy
Excessive need for admiration
Chronic envy
Arrogant and haughty attitude

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12
Q

Features of obsessive-compulsive personality disorder?

A

Is occupied with details, rules, lists, order, organization, or agenda to the point that the key part of the activity is gone
Demonstrates perfectionism that hampers with completing tasks
Is extremely dedicated to work and efficiency to the elimination of spare time activities
Is meticulous, scrupulous, and rigid about etiquettes of morality, ethics, or values
Is not capable of disposing worn out or insignificant things even when they have no sentimental meaning
Is unwilling to pass on tasks or work with others except if they surrender to exactly their way of doing things
Takes on a stingy spending style towards self and others; and shows stiffness and stubbornness

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13
Q

Features of avoidant personality disorder?

A

Avoidance of occupational activities which involve significant interpersonal contact due to fears of criticism, or rejection.
Unwillingness to be involved unless certain of being liked
Preoccupied with ideas that they are being criticised or rejected in social situations
Restraint in intimate relationships due to the fear of being ridiculed
Reluctance to take personal risks due to fears of embarrassment
Views self as inept and inferior to others
Social isolation accompanied by a craving for social contact

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14
Q

Features of dependant personality disorder

A

Difficulty making everyday decisions without excessive reassurance from others
Need for others to assume responsibility for major areas of their life
Difficulty in expressing disagreement with others due to fears of losing support
Lack of initiative
Unrealistic fears of being left to care for themselves
Urgent search for another relationship as a source of care and support when a close relationship ends
Extensive efforts to obtain support from others
Unrealistic feelings that they cannot care for themselves

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15
Q

The age group for highest rates of suicide in the UK?

A

Highest among people aged 45-54

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16
Q

What severity rating scale can be used for OCD?

A

Yale-Brown Obsessive-Compulsive Scale (Y-BOCS)

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17
Q

Symptoms of serotonin syndrome?

A

Neuromuscular excitation - hyperreflexia, myoclonus, rigidity
ANS excitation - hyperthermia, sweating
Altered mental state - confusion

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18
Q

What is Hoover’s sign?

A

A test to differentiate between the organic and functional weakness of pyramidal origin - for functional neurological disorder

It is based on the principle of crossed extensor reflex - when one hip is flexed, the contralateral hip is extended eg. if a person in supine is asked to lift the right leg with knee extended, the left heel will be observed to dig into the bed/onto your hand if its underneath their foot

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19
Q

Schneider’s first rank symptoms

A

Auditory hallucinations - voices discussing the pt in third person, thought echo or voices commenting on pt behavior
Thought disorders - insertion, withdrawal, broadcasting
Passivity phenomena - being controlled by an external source
Delusional perceptions

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20
Q

Negative symptoms of schizophrenia?

A

5As:
Affected blunted
Anhedonia
Alogia (Poverty of speech)
Avolition (Poor motivation)
Avoiding society (Social withdrawal)

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21
Q

What is catatonia

A

Abnormal movements - waxy flexibility, posturing, stereotypy etc
Immobility & mutism
Abnormal behaviours
Withdrawal

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22
Q

What is conversion disorder also known as?

A

Functional neurological disorder

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23
Q

What questionnaire can be used to assess the nature and severity of alcohol misuse

A

AUDIT
Alcohol Use Disorders Identification Test\

(AUDIT-C is a shorter version!)

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24
Q

What questionnaire can be used to screen for excessive alcohol drinking and alcoholism

A

CAGE

Cut down
Annoyed when people critique
Guilty about drinking
Eye-opener

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25
Q

What questionnaire can be used to assess risk of alcohol harm quickly?

A

FAST - Fast Alcohol use Screening Test

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26
Q

Outline features of alcohol withdrawal and their timings?

A

6-12 hrs - tremor, sweats, tachycardia, anxiety
36 hrs - seizures
48-72 hrs - coarse tremor, confusion, delusions, auditory and visual hallucinations, fever, tachycardia (this is DT)

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27
Q

Interpret PHQ9

A

<15 = less severe
>15 = more severe

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28
Q

Peak times for symptoms, seizures and DT after alcohol withdrawal?

A

6-18 hours - Sx
36 hours - seizures
72 hours - DT

(Half hours: 72 -> 36 -> 18 (6+12))

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29
Q

Causes of pseudohallucinations

A

Normal grieving process
Trauma
BPD

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30
Q

What type of hallucinations are pseudohallucinations typically?

A

Auditory or visual

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31
Q

Features of mania?

A

Psychotic symptoms - delusions of grandeur, auditory hallucinations
Elevated mood
Irritable
Pressure speech, flight of ideas and poor attention
Insomnia
Loss of inhibitions: risk-taking, sexual promiscuity, overspending
Increased appetite

32
Q

Mania vs hypomania?

A

Mania lasts at least 7 days, causes severe functional impairment, and may present with psychotic symptoms
Hypomania lasts for <7 days, can be high functioning and does not exhibit any psychotic symptoms

33
Q

Physiological abnormalities of anorexia nervosa?

A

Hypokalaemia
Low FSH, LH, oestrogen and testosterone
Raised cortisol and GH
Impaired glucose tolerance
Hypercholesterolaemia
Hypercarotinaemia
Low T3

34
Q

Diagnostic criteria for anorexia nervosa?

A

Restriction of energy intake relative to requirements leading to significantly low body weight
Intense fear of gaining weight or becoming fat, even though underweight
Disturbance in the way in which ones body weight or shape is experienced, denial of seriousness of current low body weight

35
Q

Features of PTSD?

A

Re-experiencing e.g. nightmares and flashbacks
Avoidance of things associated with the event
Hyperarousal e.g. hypervigilance, exaggerated startle response, sleep problems, irritability, diffiuclty concentrating
Emotional numbing e.g. feeling detached, lack of ability to experience feelings

36
Q

Examples of non-selective MAOIs?

A

Tranylcypromine
Phenelzine
Isocarboxazid

37
Q

Examples of selective MAOIs?

A

Selegiline
Rasagiline

38
Q

Moa of non-selective vs selective MAOIs?

A

Non-selective - inhibit MAO-A and B = increase serotonin, norepinephrine and dopamine
Selective - only inhibit MAO-B = increase dopamine so used to Tx parkinsons

39
Q

Features of acute stress disorder?

A

Within 4 weeks of the event…
Intrusive thoights
Dissociation
Negative mood
Avoidance
Arousal e.g. hypervigilance and sleep disturbance

40
Q

What is catatonia?

A

A neuropsychiatric syndrome characterised by abnormal movements, immobility, abnormal behaviours and withdrawal
E.g. Sitting or standing in the same position for hours

Usually caused by schizophrenia

41
Q

What is an oculogyric crisis?

A

An acute dystonia reaction to certain drugs or medical conditions
Causes restlessness, agitation and involuntary upward deviation of the eyes

42
Q

What can cause oculogyric crises?

A

Antipsychotics
Metoclopramide
Postencephalitic parkinsons disease

43
Q

Features of paranoid personality disorders?

A

Hypersensitivity and unforgiving attitude when insulted
Unwarranted tendency to question the loyalty of friends
Reluctance to confide in others
Preoccupation with conspirational beliefs and hidden meaning
Unwarranted tendency to perceive attacks on their character

44
Q

Moa of chlordiazepoxide?

A

It’s a long acting benzodiazepine
It works by enhancing the effects of the inhibitory neurotransmitter GABA by increasing the frequency of chloride channels

45
Q

Adverse effects of clozapine?

A

Agranulocytosis and neutropenia
Reduced seizure threshold
Constipation and risk of intestinal obstruction & perforation
Myocarditis
Hypersalivation

46
Q

Monitoring before starting clozapine?

A

Baseline ECG
FBC, LFT, U&E, CRP
Troponin
Random BG
Lipids and weight

47
Q

Monitoring whilst on clozapine?

A

FBC for leukocytes every week for 18 weeks and then fortnightly for up to 1 year and then monthly
Blood lipids and weight every 3 months for the first year and then yearly
Fasting BG after 1 month and then every 4-6 months

48
Q

Why is it important to know if a pt has stopped or started smoking whilst on clozapine?

A

As dose adjustment may be required
Smoking is a potent inducer of CYP1A2 which reduces serum clozapine concentrations

49
Q

How long does a pt have to be experiencing trouble falling asleep for a diagnosis of chronic insomnia?

A

3 nights a week at least for 3 months or longer

50
Q

Adverse effects of lithium?

A

N&V
Diarrhoea
Fine tremor
Nephrogenic diabetes insipidus
Hypothyroidism
Weight gain
Idiopathic intracranial hypertension
Leucocytosis
Hyperparathyroidism -> hypercalcaemia

51
Q

Monitoring requirements when on lithium?

A

After starting or changing dose, check lithium levels weekly at 12 hours post-dose. Once stable then check every 3 months
Asses renal, cardiac, thyroid function before starting treatment. ECG if CVD or RF for CVD, BMI, serum electrolytes and FBC before treatment starts
Monitor BMI, serum electrolytes, eGFR, TFT every 6 months during treatment.

52
Q

What are the features of brief psychotic disorder?

A

At least 1 positive psychotic symptoms
Symptoms are short term i.e. <1 month
Pt returns to normal baseline functioning afterwards

53
Q

When do acute dystonia reactions typically occur after starting drug/changing dose?

A

Within the first 4 days

54
Q

Wernickes vs korsakoffs?

A

Wobbly wernickes - ophthalmoplegia, confusion, ataxia
Konfabulatory korsakoffs - confabulations, anterograde and retrograde amnesia

55
Q

SE of benzodiazepines?

A

Drowsiness
Confusion
Ataxia
Dizziness
Slurred speech
Muscle weakness
Anterograde amnesia
Constipation
Nausea
Dry mouth
Blurred vision
Respiratory depression with high doses
Sleep disorders
Tremor
Vision disorders

56
Q

Benzos vs barbiturates MOA?

A

Ben likes it often and Barb likes it long
Benzos - increase frequency pf Cl- channels to enhance effects of GABA
Barbiturates - increase the duration of Cl- channels opening to enhance the efefcts of GABA

57
Q

Features of avoidant personality disrder?

A

Avoidance of occupation activities which involve significant interpersonal contact due to fears of criticism or rejection
Unwillingness to be involved unless certain of being liked
Preoccupied with ideas that they are being criticised or rejected in social situations
Restraint in intimate relationships due to fear of being ridiculed
Reluctance to take personal risks due to fears of embarrassment
Views self as inept and inferior to others
Social isolation but a craving for social contact

58
Q

Lifetime risk of bipolar disorder in the UK population?

A

2%

59
Q

Lifetime risk of schizophrenia if a sibling has schizophrenia?

A

10%

60
Q

What % of all deaths globally are caused by suicide?

A

1.3%

61
Q

What % of completed suicides are pts with a psychiatric Hx?

A

> 90%

62
Q

Types of schizophrenia?

A

Paranoid - most common
Hebephrenic/disorganised
Catatonic
Undifferentiated
Residual
Simple
Cenesthopathic
Unspecified

63
Q

Features of Phaeochromocytoma?

A

Hypertension
Headaches
Palpitations
Sweating
Anxiety

64
Q

Diagnostic test for Phaeochromocytoma?

A

24 hour urinary collection of metanephrines

65
Q

Features of serotonin syndrome?

A

Neuromuscular excitation - hyperreflexia, myoclonus, rigidity
Autonomic nervous system excitation - hyperthermia and sweating
Alternated mental state

66
Q

What can precipitate lithium toxicity?

A

Dehydration
Renal failure
Drugs - Diuretics, ACEi/ARBs, NSAIDs and metronidazole

67
Q

What is somnambulism?

A

Sleep walking

68
Q

What is Asperger’s?

A

What doctors sometimes refer to as high functioning autism

69
Q

Features of opioid misuse?

A

Rhinorrhoea
Needle track marks
Pinpoint pupils
Drowsiness
Watering eyes
Yawning

70
Q

Features of Ecstacy use?

A

Agitation, anxiety confusion, ataxia
Tachycardia and hypertension
Hyponatraemia
Hyperthermia
Rhabdomyolysis

71
Q

What causes hyponatraemia in Ecstacy poisoning?

A

SIADH
Excessive water consumption whilst taking Ecstacy

72
Q

Features of LSD toxicity?

A

Impaired judgements which can lead to injury
Amplification of current mood
Agitation
Drug-induced psychosis
Nausea
Headaches
Palpitations
Dry mouth
Drowsy
Tremors
Pyrexia
Tachycardia, hypertension, Mydriasis, paraesthesia, hyperreflexia

73
Q

Complication sof massive LSD overdose?

A

Respiratory arrest
Coma
Hyperthermia
Autonomic dysfunction
Bleeding disorders

74
Q

Adverse effects of cocaine?

A

Cardiovascular -> coronary artery spasm causing MI, tachycardia, bradycardia, hypertension, QRS widening and QT prolongation, aortic dissection
Neurological -> seizures, Mydriasis, hypertonia, hyperreflexia
Psychiatric effects -> agitation, psychosis, hallucinations
Ischaemic colitis
Hyperthermia
Metabolic acidosis
Rhabdomyolysis

75
Q

MOA of cocaine?

A

Blocks the uptake of dopamine, noradrenaline and serotonin

76
Q

Benzodiazepine withdrawal sundrome?

A

Up to 3 weeks after stopping…
Insomnia
Irritability
Anxiety
Tremor
Loss of appetite
Tinnitus
Perspiraopn
Perceptual disturbances
Seizures

77
Q

What is pathological intoxication to alcohol?

A

A temporary psychotic reaction which is triggered by consumption of alcohol by a person with pre-disposing mental/physical condition
Often manifested by violence