OBS&GYNAE Flashcards

1
Q

At what gestation would a referral to the maternal foetal medicine unit for no foetal movements be done?

A

24 weeks

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2
Q

Whats the most common adverse effect of the progesterone-only pill?

A

Irregular vaginal bleeding

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3
Q

If Bishop score <=6, what should be done to induce labour?

A

vaginal prostaglandins or oral misoprostol

mechanical methods such as a balloon catheter can be considered if the woman is at higher risk of hyperstimulation or has had a previous caesarean

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4
Q

If bishop score >6 what should be done to induce labour?

A

Amniotomy and IV oxytocin infusion

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5
Q

After pregnancy, when can the contraceptive implant be safely inserted?

A

Any time!

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6
Q

What is the most common risk following a surgical termination of pregnancy?

A

Infection

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7
Q

How does cholestasis of pregnancy present differently yo acute fatty liver of pregnancy?

A

AFL of pregnancy - malaise, fever, n&v, abdo pain, jaundice, ALT very elevated (very non-specific)
Cholestasis - severe pruritus often in palms and soles and raised bilirubin

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8
Q

How should you manage a woman in labour when there is foetal bradycardia <80bpm?

A

Rule of 3 mins for foetal bradycardia:
3 minutes - call for help
6 minutes - move to theatre
9 minutes - prepare for delivery
12 minutes - deliver the baby as cat 1 c-section

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9
Q

What should always be done at any sensitising event after 20/40 in a woman who is rhesus D negative?

A

A kleihauer test after giving anti-D to determine if additional anti-D is required

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10
Q

Management of gestational diabetes if fasting glucose level is >=7.0mmol/l?

A

Immediate insulin

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11
Q

When do baby blues start and when does PND start?

A

Baby blues are typically seen 3-7 days following birth
PND usually starts within 1 month and peaks at 3 months

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12
Q

Risk factors for placenta praevia

A

multiparity
multiple pregnancy
previous caesarean section - Embryos implant in scar

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13
Q

How does placenta praevia present?

A

Shock in proportion to visible loss
Lie and presentation may be abnormal

(No pain or tender uterus and foeta;l heart good)

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14
Q

What is grade 1 placenta praevia?

A

I - placenta reaches lower segment but not the internal os

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15
Q

What is grade 2 placenta praevia?

A

II - placenta reaches internal os but doesn’t cover it

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16
Q

What is grade 3 placenta praevia?

A

placenta covers the internal os before dilation but not when dilated

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17
Q

What is grade 4 placenta praevia?

A

IV (‘major’) - placenta completely covers the internal os

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18
Q

First line investigations for PMB?

A

TVUS

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19
Q

What UKMEC category is having positive antiphospholipid antibodies e.g. SLE/

A

4 - i.e. There is an unacceptably high clinical risk and she cannot use the pill anymore

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20
Q

What is the risk of chickenpox in pregnancy for the mother?

A

5 times greater risk of pneumonitis

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21
Q

What are features of foetal varicella syndrome?

A

Skin scarring
Eye defects e.g. microphthalmia
Limb hypoplasia
Microcephaly
Learning disabilities

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22
Q

Management if 2 COCP pills are missed in week 1 and they had unprotected sex during this week or the pill-free interval?

A

Consider emergency contraception

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23
Q

Risk factors for ectopic pregnancy?

A

Any damage to tubes e.g. PID, surgery
Previous ectopic
Endometriosis
IUCD
POP
IVF

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24
Q

What % of IVF pregnancies are ectopic?

A

3%

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25
Q

What drug class is leuprolide?

A

GnRH agonist

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26
Q

What can be used to screen for depression in the peurperal period?

A

The Edinburgh Postnatal Depression Scale

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27
Q

When does puerperal psychosis typically start?

A

2-3 weeks following birth

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28
Q

What is the most effective form of contraception?

A

Implantable contraceptive

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29
Q

Moa of mifepristone in termination of pregnancy?

A

acts as an anti-progestogen that primes the uterus to enhance its responsiveness to misoprostol

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30
Q

Moa of misoprostol in termination of pregnancy?

A

A prostaglandin analogue

Misoprostol binds to smooth muscle cells in the uterine lining to increase the strength and frequency of contractions as well as reduce cervical tone

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31
Q

What is placenta accreta?

A

the attachment of the placenta chorionic villi attach to the myometrium, rather than being restricted within the decidua basalis

32
Q

What is the complication of placenta accreta?

A

Postpartum haemorrhage

33
Q

How does placental abruption present?

A

Shock out of keeping with visible loss
Pain with a tender and tense uterus
Foetal heart absent or distressed
Coagulation problems

34
Q

Indications for referring a woman to hospital with hyperemesis gravidarum?

A

Continued nausea and vomiting and is unable to keep down liquids or oral antiemetics
Continued nausea and vomiting with ketonuria and/or weight loss (greater than 5% of body weight), despite treatment with oral antiemetics
A confirmed or suspected comorbidity (for example she is unable to tolerate oral antibiotics for a urinary tract infection)

35
Q

What is yhe criteria for lactational amenorrhoea?

A

Amenhorrhoic
A bay <6 months
Breastfeeding exclusively

36
Q

When are OGTT done?

A

As soon as possible after booking
At 24-28 weeks if first test is normal or if any risk factors

37
Q

What condition causes a raised AFP?

A

Neural tube defects
Abdominal wall defects
Multiple pregnancies

38
Q

What condition causes a low AFP?

A

Down’s syndrome
Trisomy 18
Maternal DM

39
Q

Indications for induction of labour?

A

prolonged pregnancy
prelabour premature rupture of the membranes
maternal medical problems e.g. DM >38 weeks, pre-eclampsia, obstetric cholestasis
intrauterine fetal death

40
Q

Interpretation of bishop score?

A

a score of < 5 indicates that labour is unlikely to start without induction
a score of ≥ 8 indicates that the cervix is ripe, or ‘favourable’ - there is a high chance of spontaneous labour, or response to interventions made to induce labour

41
Q

How long should metoclopramide be used for for hyperemesis gravidarum and why?

A

No more than 5 days due to risk of extrapyramidal side efefcts

42
Q

Risk factors for endometrial cancer?

A

Excess oestrogen
Metabolic syndrome
Tamoxifen
HNPCC

43
Q

A 31-year-old woman complains of intermittent pain in the left iliac fossa for the past 3 months. The pain is often worse during intercourse. She also reports urinary frequency and feeling bloated. There is no dysuria or change in her menstrual bleeding

A

Ovarian cyst - can cause abdominal swelling na pressure effects on bladder

44
Q

After giving birth when do women require contraception?

A

After day 21

45
Q

What is a threatened miscarriage?

A

Painless vaginal bleeding occurring before 24/40
Bleeding is often less than menstruation and cervical os is closed

46
Q

What is a missed miscarriage?

A

Aka a delayed miscarriage

a gestational sac which contains a dead fetus before 20/40 without the symptoms of expulsion
mother may have painless, light vaginal bleeding / discharge and the symptoms of pregnancy disappear
cervical os is closed

47
Q

What is an anembryonic pregnancy?

A

When the gestational sac is >25mm and no embryonic/foetal parts can be seen

48
Q

What is an inevitable miscarriage?

A

heavy bleeding with clots and pain
cervical os is open

49
Q

What is an incomplete miscarriage?

A

not all products of conception have been expelled
pain and vaginal bleeding
cervical os is open

50
Q

Outline the scanning for placenta praevia after its first recognised at the 20 week scan?

A

Rescan at 32/40. If present and grade 1/2 then rescan every 2 weeks
Final USS at 36-37/40 to determine method of delivery (if grade 1 vaginal, any higher than elective c-section)

51
Q

Moa of ursodeoxycholic acid?

A

This inhibits the absorption of cholesterol in the intestine and secretion of cholesterol into bile = decreasing biliary cholesterol saturation and promoting bile acid secretion

52
Q

What % of pregnant women get obstetric cholestasis?
Which ethnicities is it more common in?

A

1% of pregnant women
Women of Indian-Asian or Pakistani-Asian origin

53
Q

When does obstetric cholestasis usually develop and why?

A

Usually after 28/40/third trimester due to the increased oestrogen and progesterone levels

54
Q

Outline the pathophysiology of obstetric cholestasis?

A

Outflow of bile acid flow is reduced causing them to build up in the blood and this causes pruritis

55
Q

What is the risk of obstetric cholestasis?

A

Increased risk of premature birth
May increase the chance of stillbirth if severe

56
Q

What is a partial hydatidiform mole?

A

When 1 ovum with 23 chromosomes is fertilised by 2 sperm, each with 23 chromosomes = triploid cell
A foetus will be present but abnormal

57
Q

What is a complete hydatidiform mole?

A

When 1 empty ovum without any chromosomes is fertilised by 1 sperm which duplicates, (or less commonly by 2 sperm) leading to 46 chromosomes of paternal origin alone = no foetus!

58
Q

Are complete and partial molar pregnancies benign?

A

Yes but they can become malignant
Complete molar pregnancies have a 15% chance of developing to gestational trophoblastic neoplasia

59
Q

What are the 3 types of invasive gestational trophoblastic disease?

A

Choriocarcinoma
Placental site trophoblastic tumour
Epitheloid trophoblastic tumour

60
Q

What is a choriocarcinoma?

A

A type of gestational trophoblastic disease - a maliganncy of the trophoblastic cells of the placenta
Commonly co-exists with molar pregnancies
Characteristically metastases to the lungs

61
Q

USS findings for a complete hydatidiform mole?

A

A snow stop appearance of mixed echogenicity

62
Q

When can you start the COCP after levonorgestrel emergency contraception?

A

Immediately

63
Q

When should folic acid be taken as antenatal care?

A

Folic acid 400mcg OD 3 months before conception up to 12 weeks gestation

64
Q

What is the Hb cut off for anaemia in the first trimester of pregnancy?

A

<110g/L

65
Q

What is the Hb cut off for anaemia in the second and third trimester of pregnancy?

A

<105g/L

66
Q

What is the Hb cut off for anaemia in the postpartum?

A

<100g/L

67
Q

What are the requirements for an instrumental delivery? (Remember using FORCEPS mnemonic)

A

Fully dilated cervix
OA position
Ruptured membranes
Cephalic
Engaged presenting part
Pain relief
Sphincter bladder empty

68
Q

What should be the next important investigation if you find a baby has a SFH of 25cm at 30/40?

A

US to confirm foetal size

69
Q

When should magnesium sulphate be given in eclampsia?

A

Give once a decision to deliver has been made and continue for 24 hours after last seizure of delivery

70
Q

What should be monitored during giving magnesium sulphate for eclampsia?

A

Urine output
Reflexes
RR (respiratory depression can occur)
O2 sats

71
Q

Which women should take aspiring 75-150mg daily from 12 weeks gestation until birth?

A

Those with >=1 high risk factor for pre-eclampsia OR
>=2 moderate risk factors

72
Q

What are high risk factors for pre-eclampsia?

A

hypertensive disease in a previous pregnancy
chronic hypertension
CKS
autoimmune disease, such as SLE or APS
T1 or T2DM

73
Q

What are moderate risk factors for pre-eclampsia?

A

First pregnancy
Aged 40 or older
Pregnancy interval of >10 years
BMI of 35 or more
FHx of pre-eclampsia
Multiple pregnancy

74
Q

What is the first line investigation for PROM? Second line?

A

Sterile speculum to look for pooling of amniotic fluid in posterior vaginal vault
Vaginal fluid tests for PAMG-1 or insulin-like growth factor binding protein-1 if no amniotic fluid is demonstrated on speculum,

75
Q

What is the risk of expulsion of the IUD and IUS?

A

1 in 20
Most likely to occur in the first 3 months