Psychiatry Flashcards

1
Q

What are signs of lithium toxicity

A

slurred speech and coarse tremor
nausea and vomiting
diarrhoea
dehydration
lethargy

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2
Q

what points towards a diagnosis of fronto-temporal dementia

A

impulsivity
change in personality/aggression
young age (relatively)
lack of movement abnormalities

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3
Q

what is echopraxia

A

it is when the patient involuntarily imitates another persons movements. It is a rare feature of schizophrenia

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3
Q

what section of the Mental Health Act 1983 can be used to detain patients for up to 28 days

A

section 2

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4
Q

what medication can be given to help improve the cognitive function in Alzheimers disease

A

Donepezil

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5
Q

what is the mode of action of donepezil

A

it is an acetylcholinesterase inhibitor - increase free levels of acetylcholine in the brain

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6
Q

what is systematic desensitization

A

this is when there is exposure to a phobia/phobic stimulus that builds gradually in stages. In each stage there are relaxation techniques

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7
Q

what is somatoform disorder

A

this is when there is presence of a physical symptom that cant be explained by a physical medical condition. It is an unconscious process. Often caused by stresses in patients life/underlying psychological condition.

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8
Q

what is conversion disorder

A

this is a psychiatric condition that results in a presentation of neurological symptoms without any underlying neurological cause

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9
Q

what is malingering

A

this involves patients intentionally fabricating or inducing illness for secondary gain such as drug seeking, time off work, avoiding going to prison ect.

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10
Q

what is hypochondriasis

A

this is when patients have an excessive concern that they have a serious illness despite a lack of evidence.

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11
Q

what is the most appropriate management of a mother who has postpartum psychosis

A

Seen as an emergency and the patient would need admission to a mother and baby unit

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12
Q

what is a cotard delusion

A

a delusion that a patient is dead, non-existent or rotting

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13
Q

what is knights move thinking

A

this is when there is a lack of apparent connections between ideas - words remain in the form of sentences

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14
Q

what are Neologisms

A

these are new words coined by the patient - schizophrenia

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15
Q

what is Logoclonia

A

this is when a patient repeats the last syllable of a word or phrase

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16
Q

what is echopraxia

A

this is when a patient imitates another persons movements and is seen in severe schizophrenia

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17
Q

what is the SUSS test

A

this is the sit up squat stand test and assesses muscle wasting in patients with anorexia nervosa.
- sit up test the patient lies flat on a firm surface and attempts to sit up without using their hands
- squat test patient is asked to rise from a squatting position without using their hands

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18
Q

what do NICE guidelines recommend as first line treatment for mild to moderate dementia

A

donepezil
rivastigmine
galantamine

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19
Q

what is the first line treatment of autoimmune encephalitis

A

steroids and IV immunoglobulins

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20
Q

what is schizotypal personality disorder characterised by

A

unusual social behaviour, bizarre or magical thinking and distorted perceptions
- unlike in schizophrenia these patients are able to maintain a grasp on reality and do not hold their unusual beliefs with such unwavering certainty

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21
Q

what is the treatment for severe alzheimers disease

A

Memantine

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22
Q

what are side effects of memantine

A

feeling sleepy or dizzy, headaches, constipation and shortness of breath

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23
Q

what is the triad associated with lewy body dementia

A

REM sleep disorder
history of falls
hallucinations

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24
what is akathisia
it is the feeling of inner restlessness and tension, an urge to constantly move parts of the body, especially the legs, and difficulty maintaining a posture for a few minutes
25
what drugs can cause akathisia
antipsychotics - first generation such as haloperidol are more likely to cause it than second generation
26
what is conversion disorder
this is the presence to neurological symptoms without any underlying neurological causes - often linked with emotional distress
27
how long must PTSD symptoms be present for it to be diagnosed
at least 1 month and must interfere with day to day activities
28
what is the most common side effect of clozapine
Constipation due to impairment of intestinal peristalsis
29
what is histrionic personality disorder
this is characterised by attention seeking behaviour, they are willing to be viewed as dependent on others and weak to gain attention. They use speech/dress to seek attention - dont display self harm or suicidal behaviour
30
what is dependent personality disorder
this is characterised by fear of abandonment. They will have excessive reliance on caregivers and they may feel unable to make decisions when the caregiver is not around
31
What is Russells sign
this is scarring of the knuckles indicative of bulimia
32
what is tardive dyskinesia
this is repetitive movements often affecting the face and jaw. This is often due to antipsychotic medication
33
For what time period must symptoms be seen before a diagnosis of depression can be made?
Depression can be diagnosed if symptoms are present nearly every day for 2 weeks or longer
34
what is the ICD 10 diagnostic criteria for dementia
Disturbance of multiple higher cortical functions - memory - thinking - orientation - comprehension - calculation - learning capacity - language - judgement - consciousness is not clouded
35
what is the ICD 10 diagnostic criteria for delirium
disturbances of - consciousness - attention - perception - thinking - memory - psychomotor behavior - emotion - sleep wake schedule severity ranges from mild to severe
36
what is the ICD 10 diagnostic criteria for schizophrenia
Positive symptoms - thought echo, insertion, withdrawal, broadcasting - delusions of perception - delusions of control - over valued ideas - auditory hallucinations with 3rd person voice - catatonic behaviour Negative symptoms - blunted affect - apathy, loss of drive - social isolation - poverty of speech - poor self care
37
what is the ICD 10 diagnostic criteria for depression
symptoms for 2 weeks with sustained dysfunction triad of: lowering of mood, anhedonia, reduction of energy plus - decreased concentration - reduced self confidence and self esteem - ideas of guilt and worthlessness - poor sleep and early waking - loss of appetite - loss of weight - loss of libido - psychomotor retardation
38
what is the ICD 10 diagnostic criteria for mania
symptoms or features for 7 days with sustained dysfunction - elevated mood - distractable - delusions of grandeur - flight of ideas - pressure of speech - disinhibited ideas - decreased need for sleep - increased energy
39
what are features of panic disorder
recurrent panic attacks of severe anxiety somatic symptoms - heart racing, sweating, cant breath etc feeling of unreality - depersonalisation or derealisation recurrent over one month
40
what are features of obsessive compulsive disorder
recurrent obsessional thoughts or compulsive acts obsessional thoughts are: ideas, images, impulses compulsive acts or rituals are stereotypes behaviours that are repeated to prevent some objectively unlikely event anxiety worsens if compulsions are ignored
41
what are features of generalised anxiety disorder
anxiety that is general and consistent (not about one specific thin) complaints of persistent nervousness, trembling, muscular tensions, sweating, light headedness, palpitations, dizziness
42
what are features of phobias
this is anxiety at particular events/situations/things situations are avoided to prevent anxiety secondary = fear of dying, losing control or going mad phobic anxiety and depression often coexist
43
what are features of anorexia nervosa
deliberate and sustained weight loss induced and sustained by the patient dread of fatness under nutrition of varying severity with changed in body function restrictive dietary choice including excessive exercise, induced vomiting and use of appetite suppressants and diuretics
44
what are features of bulimia nervosa
repeated bouts of overeating and preoccupation with the control of body weight pattern of overeating followed by purging/vomiting repeated vomiting is likely to give rise to disturbances of the body electrolytes and physical complications can have bulimia without purging - controlled by excessive exercise or restrictive eating after
45
what is dependance syndrome
this is behavioural, cognitive and physiological phenomena that develops after repeated and sustained substance use - strong desire to take the drug - difficulties in controlling its use - persistent use despite harmful consequences - higher priority given to the drug than other activities and obligations
46
what are examples of cholinesterase inhibitors
donepezil rivastigmine galantamine
47
what are side effects of cholinesterase inhibitors
agitation dizziness fatigue insomnia headaches
48
what conditions do you have to take care with when prescribing cholinesterase inhibitors
cardiac problems asthma COPD urinary retention
49
what are NMDA receptor antagonists used for
Alzheimer's disease
50
what is an example of a NMDA receptor antagonist
memantine
51
what are side effects of NMDA receptor antagonists
constipation dizziness drowsiness
52
when would you avoid prescribing NMDA receptor antagonists
in hepatic impairment and if the patient is on antipsychotics
53
what are examples of SSRIs
citalopram fluoxetine paroxetine sertraline
54
what are side effects of SSRIs
GI problems diarrhoea abdominal pain insomnia nausea sexual dysfunction
55
what SSRI can cause QT prolongation
citalopram
56
what SSRI is used in children and adolescents
fluoxetine
57
what are examples of SNRIs
duloxetine venlafaxine
58
what are side effects of SNRIs
GI problems diarrhoea nausea abdominal pan sexual dysfunction drowsiness palpitations fatigue anxiety dry mouth rhabdomyeitis SIADH
59
what diseases should you be cautious of when prescribing SNRIs
cardiac disease mania - can make worse seizures
60
what are examples of tetracyclic antidepressants
mianserin mirtazapine
61
what are the side effects of tetracyclic antidepressants
cardiac problems diabetes mellitus seizures
62
what are examples of tricyclic antidepressants
amitriptyline clomipramine imipramine
63
what are side effects of tricyclic antidepressants
fatigue oedema postural hypotension abdominal problems dry eyes
64
who should you not prescribe tricyclic antidepressants to
patients with risk of overdosing
65
what are examples of atypical antipsychotics
aripiprazole clozapine olanzapine quetiapine
66
what are side effects to atypical antipsychotics
weight gain hyperlipidaemia hypercholesterolaemia hypersalivation sexual problems
67
what is the risk when on clozapine
risk of agranulocytosis and neutropenia
68
what are examples of mood stabilisers
lithium valproic acid carbamazepine lamotrigine atypicals
69
what are common side effects with mood stabilisers
GI problems nausea
70
which mood stabiliser needs regular monitoring
lithium
71
which mood stabiliser should not be prescribed to people below 55, particularly women of child baring age
sodium valproate
72
what disorders is CBT used in
depression anxiety disorders mood disorders eating disorders psychotic disorders
73
what disorders is dialectic behavioural therapy used in
emotionally unstable personality disorder
74
how does dialectic behavioural therapy work
it refers to the way in which someone thinks, and helps people unlearn unhelpful ways of thinking uses a mix of CBT and mindfulness and psychotherapy
75
what disorders in psychotherapy used in
complex clinical conditions - where the therapist spends time with the patient helping them to explore their thought, feelings, emotions etc
76
how is mental capacity assessed
assessed using 4 domains 1. can the patient understand what is being said to them - understand the nature of the treatment 2. retain that information 3. use that information to make an informed decision 4. relay their decision back to the medical practitioner
77
what are the 5 principles of the mental capacity act (2005)
1. capacity is assumed 2. practical steps are taken to help 3. allow unwise decisions 4. best interest 5. least restrictive
78
what is a section 2 under the Mental health act 1983
assessment for up to 28 days
79
what is a section 3 under the mental health act 1983
treatment for up to 6 months
80
what is a section 4 under the mental health act 1983
emergency admission for 72 hours
81
what is a section 5(2) under the mental health act 1983
doctors holding power for 72 hours
82
what is a section 5(4) under the mental health act 1983
nurses holding power for 6 hours - have to be a mental health nurse or learning disability nurse
83
what is section 135
it is the warrant the police can use to enter you home - there is a type 1 and type 2
84
what is section 136
it is what the police can use to have someone assessed who is in a public place
85
what is section 17a
this is a community treatment order - normally after a section 3 when someone leaves hospital that allows them to be recalled without another MHA assessment
86
what are the clinical features of someone with emotionally unstable personality disorder
impulsive angry hedonistic unstable low self esteem chronic emptiness self harm unstable relationships
87
what are the clinical features of someone with paranoid personality disorder
sensitive bears grudges suspicious combative fears of infidelity self referential preoccupied with conspiracies
88
what are the clinical features of anankastic (obsessive compulsive) personality disorder
perfectionist stubborn rigid unable to delegate pays undue attention to detail
89
what are clinical features of anxious personality disorder
worried isolated avoids social situations inadequate poor self image
90
what are the clinical features of dissocial/antisocial personality disorder
uncaring callous lacking remorse manipulative violent blames others amoral
91
what are clinical features of schizoid personality disorder
cold aloof detached indifferent to praise/criticism solitary emotionally blunted
92
what are the clinical features of histrionic personality disorder
dramatic vain self obsessed centre of attention sexual shallow obsessed with appearance
93
what are the clinical features of narcissistic personality disorder
grandiose views themselves as special jealous self centred manipulative prone to fantisies
94
what are the clinical features of schizotypal personality disorder
strange odd behaviour strange beliefs out of keeping with societal norms not fully psychotic
95
what are clinical features of dependent personality disorder
needy low self esteem unable to make decisions fears being alone
96
what are the three main developmental processes of personality disorders
1. constitutional deposition - emotional instability, anxiousness, impulsiveness 2. conditions during childhood - trauma, neglect, abuse, deprivation 3. social context - opinions about themselves and the world
97
what are the three groups of personality disorders
eccentric/odd - group A emotional/erratic - group B anxious/fearful - group C
98
what are characteristics of a schizoid personality disorder
they show emotional coldness they omit close friends and lack close friends they are isolated and take pleasure in few activities they have a restricted interest in sex it is more common in men
99
what is the ICD10 criteria for a schizoid personality disorder diagnosis
4 of the following - anhedonia -emotional coldness - lack of feelings towards others - indifference to praise or criticism - sexual indifference - solitary habits - no desire for close friends - disregard for social norms
100
what are characteristics of schizotypal personality disorder
magical thinking and eccentric behaviours they have paranoid ideation they experience unusual perceptions and have unusual thinking they lack friends they are socially anxious
101
what is the ICD10 criteria for schizotypal personality disorder
need a minimum of 4 of these continuously or repeatedly over at least 2 years - inappropriate affect - odd, eccentric or peculiar behaviour - poor rapport with others off beliefs or magical thinking - suspicious, paranoid - unusual perceptual experiences - vague circumstantial thinking with odd speech - occasional quasipsychotic episodes
102
what are characteristics of someone with paranoid personality disorder
spouse suspected cheating unforgiving and suspicious perceives attacks from others and sees an enemy in everyone confiding in others is feared threats are seen in benign things
103
what is the ICD10 diagnostic criteria for paranoid personality disorder
must have at least 4 of excessive sensitivity tendency to bear grudges suspicious and distorting of the facts combative personality recurrent suspicions of infidelity self referential attitude preoccupations with conspiracies
104
what are characteristics of dissocial personality disorder
cannot follow the law obligations are ignored remorselessness recklessness underhandedness unable to plan temper
105
what is the ICD10 diagnostic criteria for dissocial personality disorder
at least 3 of unconcern for others irresponsibility - disregard for social norms lack of maintaining social relationships violence: low tolerance to frustration lack of guilt or remorse prone to blaming others
106
what are characteristics of emotionally unstable personality disorder
paranoid ideas relationship instability angry outbursts and affective instability impulsive behaviours suicidal behaviour emptiness
107
what is the ICD10 diagnostic criteria for emotionally unstable personality disorder
any three from (but * is a must!!) impulsive actions quarrelsome behaviour and conflict * outbursts of anger unstable mood hedonism plus two of the following uncertain self image unstable emotional relationships recurrent threats of self harm chronic feelings of emptiness
108
what are characteristics of someone with histrionic personality disorder
provocative seductive behaviour relationships considered overly intimate needs to be the centre of attention influenced easily emotionally liable and shallow concern with physical appearance exaggerated motion
109
what is the ICD10 diagnostic criteria for histrionic personality disorder
exaggerated expression of emotions suggestibility shallow and liable affect continual excitement and being the centre of attention inappropriate seductiveness over concern with physical attractiveness
110
what are characteristics of narcissistic personality disorder
is easily jealous lacks empathy overreacts to criticism views themselves as special and exaggerates own importance manipulative of others expectations are unrealistic
111
what is the ICD10 diagnostic criteria for narcissistic personality disorder
at least 5 from: grandiose sense of self importance preoccupation of fantasies of success belief they are special and unique need for excessive admiration a sense of entitlement exploitation of relationships lack of empathy envy or belief others are envious of them arrogant behaviour
112
what are characteristics of avoidant personality disorder
avoids occupational activities views self as socially inept occupied with being rejected or criticised inhibited in new situations declines to get involved embarrassed socially refrains from intimacy
113
what is the ICD10 diagnostic criteria of avoidant personality disorder
persistent feelings of tension belief one is socially inept preoccupation with being rejected or criticised avoidance of people restrictions in lifestyle due to need for security avoidance of social events
114
what are characteristics of dependent personality disorder
difficulty making decisions go to excessive lengths to obtain help preoccupied with fear of isolation exaggerated fear of inability to cope needs others to make decisions for them difficulty disagreeing with others ending relationships is difficult for them noticeable difficulty in initiating things
115
what is the ICD10 diagnostic criteria for dependent personality disorder
allowing others to make their important choices undue compliance with others wishes unwillingness to make any demands feeling uncomfortable alone preoccupation with fears of being left alone inability to make decisions
116
what are characteristics of obsessive compulsive personality disorder (anankastic)
loses point (due to preoccupation) ability is compromised by perfectionism unable to discard worthless objects - hording friends are excluded they are often inflexible and rigid in their way reluctance to delegate stubborn
117
what is the ICD10 diagnostic criteria for obsessive compulsive personality disorder
excessive doubt reoccupation with rules, details, order perfectionism interferes with tasks/job etc preoccupation with productivity excessive pedantry - the quality of being too interested in formal rules and small details that are not important rigidity
118
what are negative symptoms of schizophrenia
Lack of emotion or small emotional range - Apathy loss of energy - Anergia lack of interest or low motivation - anhedonia affective flattening - black blunted facial expression difficulty, poverty or inability to speak reduction difficulty or inability to initiate and persist in goal directed behaviour autistic like features absent minded, reduced concentration activities of daily living are avoided
119
what are catatonic behaviours
marked decrease in reaction to the immediate surrounding environment sometimes taking the form of motionless and apparent unawareness, rigid or bizarre postures or aimless excess motor activity
120
what are examples of second generation antipsychotics
aripiprazole clozapine olanzapine paliperidone quetiapine risperidone
121
what are examples of first generation antipsychotics
chlorpromazine fluphenazine haloperidol
122
what are complications of schizophrenia
suicide and self harm anxiety and obsessive compulsive disorders depression abuse of alcohol and recreational drugs inability to work or attend school legal and financial issues hopelessness self isolation health and medical problems stigmatisation aggressive behaviour
123
what are the side effects of typical (first generation) antipsychotics
shaking trembling muscle spasms muscle twitches
124
what are side effects of both typical and atypical antipsychotics
drowsiness weight gain blurred vision constipation lack of sex drive dry mouth
125
what are extrapyramidal effects of antipsychotic medications
tardive dyskinesia - persistent involuntary movement of the lips, jaw or face and extremities pseudo parkinsonism dystonia - irregular muscle contractions akathisia - inability to sit still
126
what is neuroleptic malignant syndrome
it is a serious neurological disorder affecting the nervous system that usually develops rapidly over 24-72 hours and may occur during administration or withdrawal/change of antipsychotic medication
127
what are symptoms of neuroleptic malignant syndrome
sweating or fever with high temperature tremour, rigidity or loss of movement difficulty in speaking or swallowing rapid heart beat, very rapid breathing and changes in blood pressure changes in consciousness, from lethargy and confusion to stupor or coma
128
What ECG change may be seen in re-feeder syndrome
Prominent U waves due to the hypokalaemia
129
What is agnosia
the inability to recognise people, places or things that were once known to that person
130
What is normal pressure hydrocephalus
an abnormal buildup of cerebrospinal fluid (CSF) in the brain's ventricles (cavities). It occurs if the normal flow of CSF throughout the brain and spinal cord is blocked in some way. This causes the ventricles to enlarge, putting pressure on the brain.
131
what are the symptoms of normal pressure hydrocephalus
Wet, wobbly, wacky - urinary incontinence - gait dysfunction - dementia
132
what is the advice on taking lithium in pregnancy
lithium is known to increase the chances of developing Ebsteins abnormality (congenital abnormality), where the leaflets of the tricuspid valves are displaced
133
what is capgras syndrome
when someone believes that someone similar to them has been replaced by an exact clone (may or may not want to harm them)
134
what is Ekbom syndrome
In ekbom syndrome a patient experiences delusional beliefs that they are infested with insects/parasites and will complain of them crawling on their skin
135
what medication can be used to help curb the extrapyramidal side effects of antipsychotic medication
Procyclidine
136
what are side effects of valporate
vomiting alopecia liver toxicity pancreatitis/pancytopenia retention of fats (weight gain) oedema anorexia tremor enzyme inhibition
137
what questions as asked in CAGE alcohol questionnaire
Have you every wanted to cut down on your drinking Are people every annoyed at your drinking do you ever feel guilty by your drinking do you need a drink first think in the morning (eye opener)
138
What questions are asked in an AUDIT C questionnaire
How often do you drink (0-4) How many units do you drink per week (0-4) How often have you had over 6 units if female and over 8 units in male in the last year (>3 times = bad)
139
what questions should be asked when asking about substance intake
origin pattern quantification behaviours abstinence ask about dependence and the impact on life
140
what is harmful drinking
it is a pattern of drinking that causes health problems, includes psychological
141
what is dependence drinking
chronic disease in which a person craves alcoholic drinks and is unable to control this - require greater amounts of alcohol and have withdrawal
142
what are consequences of long term alcohol use
increased risk of mouth, throat and breast cancer stroke heart disease liver disease: cirrhosis, alcoholic liver disease brain damage/damage to nervous system depression dementia self harm
143
what are symptoms of acute alcohol withdrawal
mood change, insomnia, tremor, nausea and vomiting, confusion, hallucinations, seizures in severe cases Wernickes
144
what is given for the acute management of alcohol withdrawal
benzodiazepines IV thiamine
145
what are symptoms of Wernickes
change in mental state, ocular abnormalities, ataxia, hypotension, tachycardia, seizures, hallucinations, hypo/perthermia, spasticity
146
what are long term risks of heroin use
significant development of tolerance and dependence insomnia infections o the heart lining and valves abscesses chronic chest infections chronic and severe constipation depression antisocial personality sexual dysfunction and increased risk of STI irregular menstrual cycle increased risk of HIV and Hepatitis
147
when is clozapine used in psychiatry
it is used in treatment resistant schizophrenia - someone who has not responded to or has not tolerated two previous antipsychotic medications (in which one has to be an atypical medication)
148
what happens if someone hasnt taken their clozapine for 48 hours
after 48 hours their healthcare provider must be contacted and the patient has to be started back down at the lowest dose as they will have a loss of tolerance
149
what is the relationship between smoking and clozapine
smoking causes clozapine to be metabolised quicker, and therefore someone may need a higher dose to get the same effect
150
what therapeutic window does lithium need to be kept between
0.4-1mmol/L measured 12 hours post dose given
151
what are side effects of lithium
nephrogenic diabetes tremors dry mouth diarrhoea GI upset increased weight underactive thyroid in pregnant women - Ebsteins phenomina
152
what things are important to check before starting lithium
BMI cardiac function heart function thyroid function renal function
153
how do you treat lithium toxicity
IV fluids stop and review medications may need haemodialysis
154
why might someone get a lithium overdose
overdose on the medication interactions - diuretics dehydration - vomiting and diarrhoea low sodium diet reduced renal function change in lithium brand
155
what are side effects of valproate
gastro pain drowsiness tremor ataxia hair loss sedation increased appetite weight gain blood dysstasias (decreased WCC, liver damage)
156
what is the main side effects of lamotrigine
skin rashes steven johnson syndrome
157
what monitoring is done for those on lithium
every six months monitor thyroid, calcium, renal function
158
what monitoring is done for valproate
liver function testing every 6 months
159
what is serotonin syndrome
it is when there is too much serotonin in the body causing neuromuscular hyperactivity, autonomic dysfunction and altered mental state
160
what are the symptoms of serotonin syndrome
agitation, anxiety, restlessness, disorientation, diaphoresis hyperthermia tachycardia nausea, vomiting tremor muscle rigidity hyperreflexia myoclonus dilated pupils ocular clonus dry mucous membranes flushed skin increased bowel sounds a bilateral Babinski sign.
161
what are general symptoms of anxiety
dizziness nausea restlessness headache tachycardia sweating insomnia panic attacks feeling tense dread low mood depersonalization and disconnect
162
what are the symptoms of a panic attack
struggling to breathe dissociation loss of control fainting symptoms chest pain
163
what is the treatment for anxiety (general)
self help - relaxation techniques talking therapies CBT medication - SSRI, pregabalin, beta blockers
164
what are causes of delirium
constipation hypoxia infection metabolic disturbance pain sleeplessness prescriptions hypo or hyperthermia organ dysfunction nutrition environmental changes drugs (CHIMPS PHONED)
165
what is delirium
it is an acute, transient and reversible state of confusion, usually as a result of a biological process - cognition is highly fluctuant
166
what is dementia
it is an irreversible, progressive decline and impairment of more than one aspect of higher brain function (concentration, memory, language, personality, emotion)
167
what is mild cognitive impairment
people with memory problems or higher critical thinking issues which is not severe enough to interfere with their everyday life - 10-15% will go onto develop dementia
168
how do you assess capacity
1. does the person understand the information relevant to the decision 2. can the person retain the information for long enough to make a decision 3. can the person weigh up the information and use it to make a decision 4. can the person communicate their decision in any way back to the practitioner
169
what are signs you would look for in someone with suspected eating disorder
malnourished slow pulse delayed capillary refill postural tachycardia low blood pressure muscle weakness back and bone pain less than 75% weight for height
170
what are important things to ask in an eating disorder history
changes in eating what do they think about food what was eaten yesterday do they vomit after eating how much exercise do they do ask about body checking do they use diet pills/laxatives how much water do they drink do they smoke
171
what changes may you see on an ECG in someone who has an eating disorder
arrhythmias prolonged QT signs of electrolyte disturbance sinus bradycardia
172
what might the bone profile of someone with an eating disorder show
low calcium, magnesium and phosphate
173
what might U+E of someone with an eating disorder show
hyponatraemia hypokalaemia dehydration electrolyte disturbance
174
what is the treatment for anorexia
combination of talking therapy and supervised weight gain - up to 40 weeks CBT - MANTRA (understanding ED) - specialist supportive clinical management - focal psychodynamic therapy - nutritional support
175
what is the treatment for bulimia
guided help - CBT 20 sessions over 20 weeks - self care
176
what is the treatment for binge eating disorder
guided self help - CBT 20 sessions over 20 weeks
177
what is refeeding syndrome
it can happen when someone has been malnourished begins feeding again it is due to metabolising nutrients again as the body tries to do normal carbohydrate metabolism but due to low macronutrients it is unable to
178
what are symptoms of refeeding syndrome
confusions and disorientation seizures cardiomyopathy nausea and vomiting hypotension double vision swallowing issues trouble breathing kidney dysfunction muscle weakness
179
what is a learning disability
it is a condition which has an effect on a persons IQ and affects all aspects of learning and areas of life not just education - Downs syndrome, Williams syndrome, Aspergers syndrome
180
what is a learning difficulty
it doesnt affect a persons IQ/general intelligence, and will affect areas of learning but not other areas of life - dyslexia, dyspraxia, dyscalcula, dysgraphia
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what support can be given to those with learning disabilities
education services support and training for family careers choice of housing housing planning annual health check liaison workers reasonable adjustments specialist health and social care early years services help with personal budget
182
what is the link between traumatic stress and its affect on the brain
traumatic stress increases amygdala function and reduces hippocampal volumes. It increases cortisol and noradrenaline responses to stress. It also reduces the connections between the prefrontal cortex and the limbic system
183
what is attachment theory
that young children need to develop a relationship with at least one primary care giver for normal social and emotional development
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what are the types of attachment in adults
secure anxious preoccupied dismissive avoidant fearful avoidant
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what is the affect of trauma on development
difficulty in identifying, expressing and managing emotions internalise or externalise stress reactions depression, anxiety or anger aggressive behavious behaviour regression
186
what are questions you should ask when someone has self harmed
before the harm - what happened before - was the self harm planned or impulsive - have they harmed before During - were they alone - what did they use to harm themselves - was the intent to end their lives - did they want to be found After - did they seek help - what is the patients current mood
187
what questions are important to ask when someone has overdosed (self harm)
what was taken how much was taken where did you get it from how long have they been thinking about the overdose was it taken with alcohol
188
what questions are important to ask when someone cuts themselves
where are the cuts how many cuts do they have how does it make them feel when they do it is it done with the intent to kill themselves how deep are the cuts
189
what do you assess in an assessment of suicidal behaviour
the level of intent/hopelessness the level of lethality (how much do they want to die) do they live alone their level of lack of sleep or agitation their age, sex have they had mental health issues previously do they have absent rational thinking do they have any protecting factors
190
what is a hallucination
it is a false perception of objects or events involving your senses: sight, sounds, smell, touch
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what is a delusion
it is a false belief or judgement about external reality, occurring especially in mental conditions
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what are different types of hallucinations
auditory smell hearing tactile somatic gustatory
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how long must symptoms be present for someone to be diagnosed with schizophrenia
symptoms must be present for one month and supported by indications of social dysfunction at work/school/interpersonal relationships for at least 6 months
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what can be triggers for a schizophrenic episode
stress bereavement loss of job or home divorce end of relationship abuse - drug, physical, emotional, sexual
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what is substance dependence characterised by
impaired control over the substance increasing priority over other aspects of life psychological features such as neuroadaption
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what is the upper limit for alcohol consumption
14 units per weeks spread over 3 or more days
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what will happen within 6-12 hours of alcohol withdrawal
tremors autonomic arousal - tachycardia, fever, pupillary dilation, increased sweating
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what can happen within 12-48 hours of alcohol withdrawal
alcohol hallucination seizures at 36 hours
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what can happen within 72-96 hours of alcohol withdrawal
delirium tremens altered mental status hallucinations
200
what medications can be given to help someone through alcohol withdrawal
benzodiazepines Naltrexone: opiate blocker, makes alcohol less enjoyable acamprosate: increases GABA to reduce cravings Disulfiram: inhibits acetaldehyde dehydrogenase
201
how long should someone with severe alcoholism be on thiamine for once they stop drinking
two years
202
what are the symptoms of opioid withdrawal
rhinorrhoea lacrimation diarrhoea pupillary dilation piloerection tachycardia hot flushes nausea and vomiting
203
what are the effects of benzodiazepines (when not taken medically)
altered mental status slurred speech ataxia respiratory distress hypothermia euphoria disinhibition aggression anterograde amnesia labile mood
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what are effects of benzodiazipine withdrawal
tremor nausea and vomiting tachycardia postural hypotension agitation malaise hallucinations seizures
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what are examples of CNS stimulants
adderall methamphetamines cocaine
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what are the effects of CNS stimulants on the body
tachycardia, hypertension, mydriasis, tactile hallucinations, chest pain
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what are withdrawal side effects from CNS stimulants
dysphoria lethargy psychomotor agitation ]craving increased appetite insomnia
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what are examples of hallucinogens
LSD, marijuana, ecstasy, PCP
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what do components of addiction comprise of
salience - when something becomes important mood modification tolerance withdrawal relapse
210
what are features of ADHD
short attention span quickly loosing interest constant fidgeting impulsive behaviour disruptive poor organisation acting without thinking
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what are risk factors for developing ADHD
prematurity low birth weight low paternal education prenatal smoking maternal depression
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how is a diagnosis of ADHD made
made my specialist in adults use the - Diagnostic interview for ADHD in adults questionnaire use the DSM-5 criteria looking at inattention and symptoms of hyperactivity and impulsivity - children up to 16 have to have 6 or more symptoms across both categories - over 17 only need 5 ore more symptoms
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how long must symptoms be present for for ADHD to be considered
present for at least 6 months and be present in multiple settings
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how is ADHD managed
initially watch and wait period for up to 10 weeks including encouraged self care and behavioural management medication: methylphenidate
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what needs to be monitored when someone is on methylphenidate
blood pressure heart rate - measured every 6 months
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what are complications of ADHD
lower educational and employment attainment poor self esteem relationship issues sleep disturbance substance abuse self harm
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what is trait anxiety
Trait anxiety is when worry and fear permeate your experiences on a regular basis—not just in response to a stressful situation and is influenced by - stable characteristics from genetics and environment - adaptive responses to treat during childhood experienced calibrate the CNS response to a threat in adulthood
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what is state anxiety
it is the state of feeling anxious - in the disorder these symptoms become more severe and persistant
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what are some psychological symptoms of anxiety
suspense recurrent thoughts of negative outcomes reduced concentration hyper vigilance
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what is the neurobiology of anxiety
there is a reduced functional connectivity between the prefrontal cortex and the limbic system variations in 5-HT transporter resulting in reduced 5-HT signalling dysregulation of the hypothalamic-pituitary-adrenal axis
221
what are features of anxiety disorder
Avoidance Attention and cognitive bias anxious rumination low self worth poor sleep
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what is autism spectrum disorder
it is a neurodevelopmental disorder which is characterised by abnormal social interaction, communication and restricted and repetitive behaviours
223
what is Asperger's syndrome
a condition forming part of the autistic spectrum, characterized chiefly by repetitive patterns of behaviour, preoccupation with restricted interests, and difficulties with social interaction, without intellectual impairment or significant problems with verbal communication.
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what medical conditions can predispose someone to developing autism
infantile spasms congenital rubella tuberous sclerosis fragile X syndrome
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what are risk factors for autism
male sex family history genetic variants such as PTEN, MeCP chromosomal abnormalities
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what are clinical features of autism
social interaction: lack of emotional response, unable to interpret cues, inability to form social attachment communication: delayed or minimally expressive speech, impairment of make believe, lack of social gestures, one way conversation restricted, repetitive behaviour: resist change, preoccupied with specific interests, inability to adapt to new environments
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what investigations are done for autism
a clinical assessment which shows deficits across all three domains (discussed in clinical features card) - features must be observable in all environments and present from early childhood
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how is autism diagnosed
diagnostic interview for social and communication disorders autism diagnostic observation schedule
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how is autism managed non pharmacologically
non pharmacological: specialist education, occupational therapy, speech therapy, clinical psychology, sleep hygiene, care agencies
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how is autism managed pharmacologically
SSRI if the patient has anxiety or depression children with sleep issues may benefit from the use of melatonin
231
what is bipolar disorder
it is a mood disorder characterised by episodes of mania or hypomania and depression
232
what are the genetic factors can influence bipolar disorder development
1st degree relatives of a person with bipolar disorder are at an increased risk of developing bipolar, unipolar and schizophrenia - 60% chance with identical twins - polygenic inheritance
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what environmental factors can influence development of bipolar disorder
negative life events can precipitate depressive or manic episodes
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what neurobiological factors can influence development of bipolar disorder
increased dopamine activity in the brain may be important in the development of mania disturbances in the hypothalamic - pituitary- adrenal axis can result in increased cortisol secretion
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what are risk factors for developing bipolar disorder
genetic factors prenatal exposure to toxoplasma gondii premature birth childhood maltreatment postpartum period issues cannabis use
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what is Bipolar I
the person has experienced at least one episode of mania
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what is bipolar II
the person has experienced at least 1 episode of hypomania but never an episode of mania, they must have also experienced at least one episode of major depression
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what is cyclothymia
this is cycling between hypomania and depression for at least 2 years
239
what are symptoms of mania
elevated mood increased activity level grandiose delusions energy increase pressure of speech decreased need for sleep inability to maintain attention inflated self esteem loss of normal social inhibitions risky sexual activity
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what criteria needs to be met for something to be diagnosed as a manic episode
needs to last for at least 7 days and have a significant negative functional effect
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what are symptoms of hypomania
persistent elation in mood (less than in mania) increased energy and activity increased sociability talkativeness over familiarity increased sexual energy decreased need for sleep irritability
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what investigations should be done when someone presents with mania
baseline bloods - FBC, U+E, LFT, TFT, CRP, B12, folate, vitamin D, ferritin HIV testing toxicology physical exam CT head
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what is required for a diagnosis of bipolar disorder
at least 7 days of mania or at least 4 days of hypomania depression
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how is bipolar disorder managed acutely
acute: oral antipsychotics for mania (olanzapine, risperidone, etc.) if patient on antipsychotic this should be tapered off and discontinued benzodiazepines can be used in short term to manage symptoms or increased activity and allow better sleep if patient depressed need to be careful with what is given due to mania risk - fluoxetine+olanzapine, quetiapine alone, olanzapine alone, lamotrigine alone
245
how is bipolar managed long term
mood stabilisers: lithium (if not effective valproate psychotherapies: CBT, interpersonal or family focused therapies
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what are complications of bipolar disorder
increased risk of death by suicide increased risk of death by general medical conditions side effects of antipsychotics socioeconomic effects
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how are lithium levels monitored
12 hour bloods weekly initially until stable once stable do 3 monthly bloods then do bloods every 6 months
248
what are the brain changes associated with alzheimers disease
amyloid plaques and neurofibrillary fibers (tau) have a medial temporal lobe atrophy
249
what are risk factors for developing vascular dementia
hypertension smoking diabetes mellitus hyperlipidaemia obesity
250
what are clinical features of vascular dementia
cognitive impairment mood disturbance psychosis delusions paranoia
251
what are the brain changes associated with lewy body dementia
spherical lewy body proteins (alpha synuclein) are deposited within the brain
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what are clinical features of lewy body dementia
visual hallucinations parkinson like symptoms cognitive ddecline problems multitasking and performing complex tasks sleep disorders - often will present first fluctuation in cognitive ability
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what are the brain changes seen in fronto-temporal dementia
neuronal damage and cell death in the frontal and temporal lobes - atrophy occurs due the deposition of abnormal proteins (often tau)
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what are the clinical features of fronto-temporal dementia
altered mood apathy disinhibition increased impulsivity progressive decline in interpersonal skills decline in understanding words or speech difficulty in name retrieval not knowing the meaning of common words breakdown of language speech no longer fluent speech apraxia
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what can increase the chance of a child developing a learning disability
family history abuse, neglect trauma toxins genetic conditions fetal alcohol syndrome maternal chicken pox prematurity meningitis autism epilepsy
256
what are the different types of delirium you can get
hyperactive hypoactive
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how do you treat delirium
identify and treat underlying cause calm/consistent aids they may need independence orientate the patient involve family/carers in management haloperidol if antipsychotic required - 0.5mg
258
what are signs of opioid overdose
decreased level of consciousness respiratory depression pin point pupils
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what are symptoms of an opioid overdose
nausea vomiting confusion drowsiness
260
how do you manage an opioid overdose
ABCDE Naloxone - initially 400 micrograms, of no response then give 800 for up to two doses at one minute intervals (subcut/IM) oxygen- non-rebreathe mask 15L assess consciousness - AVPU scale
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how is paracetamol metabolised by the body
mostly via glucuronidation and sulphation. 5% is metabolised by cytochrome p450 into N-acetyl-p-benzoquinone imine (NAPQI) this binds to glutathione to become non toxic and is secreted in the urine
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what are the three types of paracetamol overdose
acute: excess amounts ingested quickly staggered: excess amounts ingested over longer than 1 hour therapeutic: excess ingested with the intent to treat pain/fever without self harm intent
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what are the risk factors of paracetamol overdose
history of self harm history of frequent or repeated pain medication use low body weight cytochrome p450 inducers (phenytoin, rifampicin) glutathione deficiency - ED, alcoholism
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what are the early signs of paracetamol overdose (<12 hours)
nausea and vomiting mild to moderate abdominal pain/tenderness
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what are late signs of paracetamol overdose (12-48 hours)
moderate to severe abdominal pain metabolic acidosis jaundice AKI hepatic encephalopathy coma bruising/systemic haemorrhage
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what investigations should be done with suspected paracetamol overdose
paracetamol concentration LFTs INR U+E plasma bicarbonate plasma glucose FBC lactate
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how is paracetamol overdose managed
if less than 8 hours after overdose: take bloods and start on acetylcysteine if paracetamol high if over 8 hours after overdose: bloods and if paracetamol is over 150mg/kg or the person is symptomatic start acetylcysteine immediately - if someone has taken a staggered overdose start acetylcysteine immediately regardless of level
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what is the acetylcysteine regime for paracetamol overdose
1) standard 21 hour - 150mg/kg over 1 hour then 50mg/kg over 4 hours then 100mg/kg over 16 hours 2) modified 12 hour (SNAP) : 100mg/kg over 2 hours then 200 mg/kg over 10 hours
269
what can be given if someone has overdosed on benzodiazepines
flumazenil - not always recommended as long term use can cause withdrawal seizures
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what are signs of benzodiazepine overdose
agitation euphoria blurred vision slurred speech ataxia
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what is severe aspirin overdose
over 500mg/kg
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what are signs of aspirin overdose
mild: tinnitus, lethargy, dizziness, N+V severe: dehydration, sweating, bounding pulse, deafness, breathlessness, confusion
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what investigations should be done for suspected aspirin overdose
salicylate concentration measured U+E glucose potassium urine pH ABG
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how do you treat aspirin overdose
activated charcoal within one hour of ingestion aggressive rehydration sodium bicarb if aspirin levels v.high haemodialysis in severe cases
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what is the treatment for cocaine/amphetamine overdose
benzodiazepines
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what psychiatric conditions could ECT be used in
severe resistant depression severe depressive disorder causing harm to patient catatonia severe or ongoing mania
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what does the ECT regime comprise of
6-12 sessions occurring twice weekly patient reassessed after each session and may stop before the end of the course/continue depending on the clinical presentation
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what is given before ECT to prevent physical affects of the therapy
a muscle relaxant - suxamethonium
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what are side effects of ECT
short term memory loss retrograde amnesia post ECT headache post ECT muscle aches brief confusion or drowsiness
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what are risks of ECT
risks of anaesthesia - airway issues, dental damage risk of prolonged seizure
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what are contraindications for ECT
recent MI/stroke increased intercranial pressure active bleeding retinal detachment
281
what is a hypnotic
it can sedate when given during the day
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what is an anxiolytic
it helps to induce sleep at night
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what are hypnotics used in
used in disorders relating to sleep and anxiety
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what are the most common types of hypnotics/anxiolytics
benzodiazepines
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what are examples of Noradrenaline and specific serotonergic antidepressants (NASSAs)
Mirtazapine
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what are examples of TCA antidepressants
amitriptyline imipramine
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what are examples of serotonin antagonist and reuptake inhibitors (SARIs)
trazodone
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what are examples of MAOI antidepressants
tranylcypromine phenelzine isocarboxazid
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what are side effects of TCA antidepressants
dry mouth blurred vision constipation drowsiness dizziness weight gain sweating arrhythmia impotence
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what do you need to be aware of in elderly people on antidepressants
risk of hyponatraemia - nausea - headache - muscle pain - loss of appetite - confusion - tired - disorientated
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what is the depot injection
this is a long acting antipsychotic which is given every two to four weeks
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what are examples of depot injections
flupentixol deconate zuclopenthixol deconate aripiprazole
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What is the monitoring timetable for bloods when on clozipine
weekly bloods for the first 18 weeks they bloods every other week up to 1 year after that blood tests are monthly
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what are the different types of stimulant medications for ADHD
short acting - lasts up to 4 hours, get crash after long acting - take one a day and lasts from 6-8 hours. fewer ups and downs during the day
295
what features would you see in mild learning disability
IQ between 50-69 some difficulties in acquisition and comprehension of complex language and academic skills most can manage basic self care, domestic and practical skills can live and work independently
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what features would you see in moderate learning disability
IQ 35-49 basic language and academic skills some will manage basic self care, domestic and practical skills consistent support to live alone
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what features do you see in severe learning disability
IQ 20-34 very limited language and academic skills may have motor impairments require daily support
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what features do you see in someone with a profound learning disability
IQ <20 very limited communication skills may have some basic concrete skills may have motor and sensory impairment will need daily support
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what are risk factors for learning disability
chromosomal/genetic abnormalities congenital malformations prenatal exposures - alcohol, sodium valproate, rubella, zika virus birth complications and premature birth childhood illness - meningitis, encephalitis, measles, epilepsy childhood brain injury childhood neglect
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what environmental factors can impact on a childs development of learning disabilities
care environment with little opportunity for social interaction excessive sensory stimulation care environments which are crowded, unresponsive or unpredictable abuse and neglect developmentally inappropriate care environments illness care environment where disrespectful social relationships and poor communication is typical
301
what is section 135(2)
this is when someone already in hospital goes AWOL and you need the police to bring them back in
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what year did the mental health act come out
1983
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what is a second opinion appointed doctor (SOAD)
this is a service which appoints a second opinion doctor which safeguards the rights of the patient subject to the mental health act
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under what conditions can you be sectioned
being assessed or treated for a mental health condition if you are at risk of getting worse without treatment if your safety or someone elses safety is at risk if you dont get treatment
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what is nearest relative in mental health
different to next of kin, it is something the patient doesnt have a say in - hierarchy of blood relatives - preference is given to age - preference is given to those who live with the patient
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what are predisposing factors for depression
family history age female personality traits childhood trauma lack of social support marital status
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what are precipitating factors for depression
substance abuse physical health traumatic life events low self esteem lack of social support poor socioeconomic status
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what are perpetuating factors for depression
substance abuse physical health failure to cope with loss ongoing loss lack of support
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what are protective factors for depression
current employment good social support being in a relationship
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what are biological risk factors for developing depression
genetics personality physical illness serotonin imbalance neuroendocrine issues substance misuse
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what physiological risk factors can predispose someone to depression
traumatic life events low self esteem lack of education
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what are biological symptoms of depression
anhedonia loss of emotions diurnal changes early morning waking agitation appetite and weight change delusions hallucinationa
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what is the diagnostic criteria for mild, moderate and severe depression
Mild: two typical core and two other symptoms Moderate: two typical core and at least 3 other symptoms Severe: all three typical core symptoms and at least 4 other symptoms
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how do you manage depression
mild: self help, guided CBT, mindfulness, interpersonal psychotherapy, SSRIs, counselling moderate: CBT and SSRIs, individual CBT and behavioral therapy, psychotherapy Severe: consider antipsychotics and ECT. same management as above. Need regular risk assessments.
315
what are complications of depression
suicide self harm substance misuse recurrence of depression reduced quality of life antidepressant side effects
316
what are obsessions (in OCD)
unwanted and uncontrolled thoughts and intrusive images which are hard to ignore
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what are compulsions (in OCD)
these are repetitive actions the person feels they must do, anxiety generating, often a way to control obsessive throughs
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what are different types of obsessive compulsive disorder
OCD - obsessive type, compulsive type, mixed body dysmorphic disorder body focused repetitive behaviour disorder hypochondriasis hoarding disorder
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how is OCD managed
combination of SSRIs and psychological therapy - exposure and response prevention therapy - clomipramine (TCA) - adjunctive antipsychotics if required
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what is delusional disorder
this is one or more firmly held false beliefs that are persistent for at least 1 month. - no other psychotic symptoms
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what are different types of delusions
persecutory referential grandiose erotomanic nihilistic somatic jealous
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what are non bizarre delusions
these are situations that could occur in real life
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what are bizarre delusions
these are implausible. they reflect beliefs that would be physically impossible
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what are diagnostic criteria for delusional disorder
- presence of one of more delusion for >1 month - diagnostic criteria for schizophrenia not met - patients function not markedly impaired, behaviour not obviously bizarre or odd - disturbance is not better explained by another mental disorder
325
what are phobias
extreme anxiety triggered by particular situations or objects
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when does fear become a phobia
when the fear is out of proportion to the danger when it lasts for more than 6 months when it has significant impact on day to day life
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what are examples of phobias
animals natural environment - heights, water, dark, germs body based phobias sexual phobias food phobias
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what is social phobia
it is the sense of intense fear when in social situations - may struggle with talking in groups, starting conversations, public speaking, speaking on the phone, meeting new people, working, talking to authority figures
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what is agoraphobia
extreme or irrational fear of entering open or crowded places, of leaving one's own home, or of being in places from which escape is difficult. - may struggle out the house, being in big open space, being in crowds, traveling by car/bus/plane
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what are symptoms someone may experience with phobias
dizziness lightheadedness chest pain shortness of breath numbness dissociation
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what can be causes of phobias
trauma learned responses from childhood experiencing long term stress genetic factors
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how are phobias managed
CBT exposure therapy hypnotherapy antidepressants (SSRI) benzodiazepines for severe anxiety beta blockers for symptoms control
333
what are baby blues
these are mood changes typically in the first week or so after birth characterised by mood swings, low mood, anxiety, irritability and tearfulness. - thought to be due to significant hormone fluctuation, recovery from birth and responsibility of caring for a neonate
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what is postnatal depression
this is a triad of low mood, anhedonia and low energy typically presenting around 3 months after birth lasting at least 2 weeks
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how is postnatal depression treated
mild: additional support, self help, follow up moderate: antidepressants (SSRI) and CBT severe: specialist psychiatric help and rarely impatient help on the mother and baby unit
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what is the Edinburgh postnatal depression scale
this is used to assess how the mother has felt over the past week as a screening tool - 10 questions with total score of 30, a score of 10 or more suggest postnatal depression
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what is puerperal psychosis
it is a rare but severe condition characterised by delusions, hallucinations, depression and mania presenting typically between two to three weeks post delivery
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what can SSRIs taken in pregnancy lead to after birth
neonatal abstinence syndrome - first few days after birth baby may be irritable and have poor feeding
339
what is delirium tremens
it is life threatening alcohol withdrawal caused when someone with moderate to severe alcohol intake suddenly stops drinking. needs immediate medical care
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what are symptoms of delirium tremens
tremors shakes confusion agitation and anxiety psychosis sensory disruption disorientation bouts of heavy sweating hyperthermia headaches nausea and vomiting hallucinations
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how do you treat delirium tremens
(not fully curable) supportive therapy benzodiazepines IV fluids thiamine, folate, vitamins, electrolytes
342
what causes Wernicke's encephalopathy
it is caused by thiamine deficiency in alcoholism
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what occurs if Wernickes goes untreated
the patient can develop korsakoff syndrome - memory impairment - behavioural changes - hallucinations
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how is Wernickes treated
IV thiamine (pabrinex)
345
what issues can lithium cause when it is in its therapeutic dose
polyuria/polydipsia weight gain cognitive problems tremor sedation GI distress T wave change and wide QRS issues with renal function and hypothyroidism long term
346
what is acute dystonia
it is involuntary muscle contractions, eye spasms/blinking, twisting head or protruding tongue - can cause painful muscle contractions
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what is tardive dystonia
involves twisting of the torso and the neck - severe
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what are risk factors for developing neuroleptic malignant syndrome
dehydration rapid antipsychotic dose increase or initiation withdrawal of antiparkinsonian medication predisposing drugs
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how do you treat neuroleptic malignant syndrome
Benzodiazepines stop any causative agents supportive measures: oxygen, IV fluids, decrease temp with cooling blankets allow two+ weeks before restarting medication if rhabdomyolysis occurs then you need vigorous hydration and IV sodium bicarbonate
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how do you treat serotonin syndrome
mild: stop medication, maybe add in a serotonin blocker moderate: observed in hospital for at least 24 hours severe: ICU give benzodiazepines for symptoms iv fluids and oxygen cyproheptadine - serotonin blocking agent
351
what is catatonia
it is a state in which someone is awake but doesnt seem to respond to other people or the environment around them - can affect movement, speech and behaviour
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what are signs of catatonia
sitting and staring into space holding unusual postures holding arms and legs in whatever position someone moves them into repetitive movements repeating the same phrase over and over repeating words and phrases they hear holding strange faces not eating or drinking sudden agitation
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what are causes of catatonia
schizophrenia depression mood disorders OCD PTSD psychosis infections brain injury drug and alcohol use metabolic disorders autoimmune disorders
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how do you treat catatonia
treat the underlying cause if physical lorazepam single dose challenge - symptoms tend to improve ECT monitor nutrition and hydration
355
what can untreated catatonia lead to
AKI dehydration malnutrition pressure ulcers infections blood clots death
356
what is the DSM-5 criteria for delirium
1. disturbance in awareness and attention 2. acute onset 3. disturbance in cognition 4. not explained by pre existing conditions 5. evidence of organic cause
357
when does clozapine induced neutropenia typically occur
in the first 18 weeks of treatment
358
what are symptoms of clozapine induced agranulocytosis
fever mouth ulcer sore throat
359
how do you threat clozapine induced neutropenia
treatment is often supportive until neutrophil count is back up stop clozapine can use granulocyte colony stimulating factor to reduce agranulocytosis time
360
what effects can clozapine have on the heart
increased risk of myocarditis (inflammation of the heart), possibly due to IgE hypersensitivity can cause cardiomyopathy
361
when does clozapine induced myocarditis typically present
1-2 months after starting the medication
362
what are symptoms of myocarditis
tachycardia fever flu like symptoms chest pain breathlessness
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when does clozapine induced cardiomyopathy present
about 9 months after starting the treatment
364
what affect does clozapine have on the gut
gut hypomobility
365
why does clozapine cause gut hypomobility
thought that clozapine causes anticholinergic inhibition of the GI smooth muscle contraction and peristalsis pus it compounds the issue from serotonin receptor antagonism as serotonin plays a role in gut motility
366
what are symptoms of gut hypomobility
bloating low stool frequency distension discomfort constipation ileus (paralytic) ischaemia necrosis
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how do you prevent clozapine induced gut hypomobility
stool charts fiber in diet drinking plenty of fluid have a low threshold for reporting and gut issues !!! prescribe laxatives/stool softeners to help prevent long term constipation
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what are the signs that someone is constipated
change in bowel habit straining stomach aches feeling sick smelly wind hard stool
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when should you refer someone under suspicion of gut hypomobility
abdominal pain or discomfort for over an hour swollen or distended stomach overflow diarrhoea sickness or vomiting absent bowel sounds sepsis symptoms
370
what is psychosis
it is when the mind has lost contact with reality, resulting in disrupted thoughts and perceptions and have difficulty determining what is real and what is not
371
what are symptoms of psychosis
delusions and hallucinations incoherent speech and behaviour suspicions and paranoia trouble thinking clearly withdrawing socially overly intense or unusual ideas lack of feelings decline in self care disruption of sleep difficulty telling reality from fantasy emotional disruption harming themself or others
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what are causes of psychosis
complex combination of factors - genetics - exposure to stress/trauma - mental illness - physical illness - disease of older age - drugs and alcohol - sleep deprivation
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how do you treat psychosis
antipsychotics specialty care recovery orientated team approach therapy if trauma involved
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what is PTSD
it occurs after a traumatic event characterised by feeling numb, having trouble sleeping, and reliving the traumatic event, with the symptoms lasting over one month
375
what are the different types of PTSD
delayed onset - symptoms emerge over 6 months after the event complex - trauma at an early age/lasted a long time birth trauma - traumatic childbirth
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what is secondary trauma
It is when you experience some PTSD symptoms while supporting someone close to you who has experienced trauma
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what are symptoms of PTSD
reliving the experience nightmares intense distress alertness/feeling on edge panicking upset or angry easily hypervigilance lack of sleep irritability avoidance of feelings or memories avoiding certain places emotionally numb difficult feelings/beliefs - unable to trust
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what symptoms might someone with complex PTSD experience
difficulty controlling emotions distrustful feelings of emptiness or loneliness avoiding friendships or relationships dissociation suicidal ideation
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what is the treatment for PTSD
if the symptoms are for less than 1 month the GP may suggest watchful waiting to see sx progression talking therapy: trauma focused CBT, eye movement desensitisation and reprocessing medication may be offered to patients who are experiencing depression, sleep issues or didnt respond to talk therapy
380
what is schizoaffective disorder
it is psychosis as well as mood disorder symptoms
381
what are symptoms of schizoaffective disorder
psychosis: hallucinations, delusions, disorientation, confusion, feeling disconnected, difficulty with concentration, lack of motivation mood: excited, irritated, lack of sleep, sad, low, little connection with others
382
what are types of schizoaffective disorder
bipolar type - manic episodes along with psychosis depressive type - depressive episodes with psychosis
383
what is the diagnostic criteria for schizoaffective disorder
symptoms need to last for 1 month or longer you have psychosis and mood symptoms at the same time you have had mood symptoms for most of the time you have been unwell you have had a period of time (over 2 weeks) with psychosis without mood symptoms
384
what are causes of schizoaffective disorder
traumatic life events childhood trauma genetic predisposition
385
how is schizoaffective disorder managed
talking therapies - CBT, mindfulness, psychodynamic therapies art therapy medication: antipsychotics, mood stabilisers, antidepressants (need to be careful with these as they increase the likelihood of a manic episode)
386
what is schizophrenia
it is a mental disorder which affects thinking, perception and affect
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what are risk factors for developing schizophrenia
family history and genetics malnutrition viral infection during pregnancy drug abuse social and environmental - trauma, socioeconomic class
388
how do you diagnose schizophrenia
rule out biological cause first - bloods, urine, drug screen, syphilis/HIV screen, CT head - then use the ICD 11 criteria: at least two symptoms for most of the time for at least 1 month, with one of the symptoms being a core symptom of schizophrenia
389
what is DBT
dialect behavioural therapy - designed for people that feel emotions very deeply, helps people understand their feelings, manage them and make changes
390
what is somatisation disorder
it is when mental factors cause physical symptoms affected people tend to be emotional about their symptoms and can affect day to day life unknown cause can persist a long time
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what are examples of somatisation disorder
chest pains dizziness tiredness back pain GI upset
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what is a functional disorder
it is when something is wrong but there is no known/diagnosable cause
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what are types of somatoform disorder
somatisation disorder hypochondriasis conversion disorder body dysmorphic disorder pain disorder
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what is hypochondriasis
it is when people fear minor symptoms may be due to a serious disease - fear, lots of time thinking about symptoms - people may accept that their symptoms are minor - reassurance often doesnt help
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what is conversion disorder
person has symptoms which suggests a disease of the brain or nerves, but due to mental factors - loss of vision, deafness, weakness, paralysis
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what is pain disorder
it is when a person experiences persistent pain that cant be attributed to a physical condition or biological cause
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what is fictitious disorder
it is when someone fakes illnesses (physical or mental) which they may or may not benefit from - can also create illness or injury in another person
398
what can be given to treat insomnia
zopiclone
399
what can be given to treat narcolepsy
Modafinil (CNS stimulant) sleep hygiene
400
what HLA type is narcolepsy associated with
HLA BDQ B1 0602
401
what symptoms must be present for someone to be diagnosed with gender dysphoria
at least two of the following for at least 6 months - incongruent mental and physical appearance - strong desire for opposite gender genitalia - strong desire to be opposite gender - strong desire to be treated like the other gender - mentally feels like the opposite gender - doesnt like to look at/wants to remove own genitals or secondary sexual characteristics
402
what are symptoms of SSRI discontinuation syndrome
Dizziness electric shock sensations anxiety restlessness
403
what SSRIs can cause SSRI discontinuation syndrome
paroxetine
404
what atypical antipsychotic has the most tolerable side effect profile
aripiprazole
405
when should patients under 25 who have been started on SSRIs be reviewed
after 1 week
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when should patients over 25 who have been started on SSRIs be reviewed
after 2 weeks
407
what is a characteristic side effect of mirtazapine
increased appetite sedation
408
what antidepressants can cause the tyramine cheese reaction
MAOI = such as phenelzine this can occur when a patient eats cheese, causing a hypertensive crisis
409
what can long term lithium use lead to
hyperparathyroidism - resultant hypercalcaemia leading to symptoms of 'stones, bones, abdominal moans and psychologic moans'
410
what are the 5p's of formulation surrounding mental health disorders
predisposing precipitation presenting perpetuating protective
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what is the biopsychosocial model of risk factors and treatment of mental health illnesses
bio - genetics, birth complications, past medical history, drug history psych - trauma, abuse, self esteem, mood and personality social - relationships, finances, stress, culture
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what is delusional perception
thinking ' if A happens then B will happen' - pathognomonic for schizophrenia
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what is the difference between depersonalisation and derealisation
depersonalisation - thinks they are not real derealisation - thinks the world around them isnt real
414
what is fregoli delusion
where they believe everyone in the world is actually just one single person all wearing masks
415
what is orthello delusion
where they believe their partner to be unfaithful
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what is De cleraumbalt delusion
they believe that a high status person is in love with them (erotomania)
417
which antidepressant causes QTc prolongation
citalopram
418
when do antidepressants need monitoring
have a baseline monitor then weekly for 4 weeks then after 2 weekly
419
what are drug interactions with SSRIs
triptans decrease efficacy of SSRIs if someone is taking SSRI and NSAID you need to co-prescribe a PPI
420
what can taking SSRIs in pregnancy cause
in first trimester - CHD and cleft palate third trimester - Persistent pulmonary hypertension of the newborn
421
what are signs of a TCA overdose
confusion hot dry skin increase Ach symptoms - cramps, increased salivation, lacrimation, muscular weakness, paralysis, muscular fasciculation, diarrhea, and blurry vision
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what will be seen on ECG in TCA overdose
a wide QRS >100ms and QT prolongation >480ms
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what is the treatment for TCA overdose
IV bicarb
424
what are side effects of mirtazapine
weight gain and sedation
425
what is the correct way to stop antipsychotics
slowly reduce and then stop over 3 months to prevent a relapse
426
what bloods are needed every 12 months when someone is on antipsychotics
FBC, U+E, HbA1C, LFT, prolactin also need to do a BMI measurement
427
what are side effects of typical antipsychotics
acute dystonic reaction akathisia parkinsonism tardive dyskinesia
428
what can treat acute dystonic reaction
IM/IV procyclidine
429
what can treat akathisia
po propranolol
430
what can treat tardive dyskinesia
PO tetrabenazine
431
what are complications of neuroleptic malignant syndrome
rhabdomyolysis AKI
432
what drug interactions does lithium have
NSAIDs - AKI diuretics - increase dehydration ACEi - can precipitate lithium toxicity
433
when are the uses of couple therapy
to promote communication strength to reduce emotional avoidance to modify dysfunctional behaviour
434
what are atypical presentations of depression
increased appetite increased seep mood may seem okay on good occasions catatonia very sensitive
435
what is dysthymia
it is subclinical depression for 2 or more years
436
what are risk factors for self harm
female EUPD depression bereavement trauma or abuse LGBTQ
437
what increases the risk of suicide recurrence in someone
if they made a conscious effort to not be found if they left a note if they planned the death if they have no regret after the attempt
438
what are the different referrals to CMHT for mania and hypomania
mania requires an urgent referral hypomania requires a routine referral
439
which lobe is affected in schizophrenia
the temporal lobe
440
what are schniders first rank symptoms of schizophrenia
delusional perceptions thought alienation - insertion, withdrawal, broadcast, word salad third person auditory hallucinations passivity
441
what are second rank symptoms of schizophrenia
non auditory hallucinations catatonia delusions reduced insight
442
what are risk factors for developing anxiety
bio- genetics, stimulants, palpitations, increased T4, withdrawal psych - mental health history, trauma, abuse social - stress, life events
443
what is panic disorder
over 1 month of at least 4 weekly spells of 10-30minutes of panic attacks
444
what are the dependence terms/symptoms for addiction
withdrawal symptoms - use of substance to avoid tolerance narrow repertoire craving loss of control rapid reinforcement - quick return to old level after stopping primacy - takes precedence over physiological need continued use despite harm
445
what is the ICD 10 definition of alcohol dependence
it is 12 months of over three of the dependence symptoms/terms
446
when is disulfiram contraindicated
in pregnancy and when the person is still drinking alcohol
447
how do you treat opioid addiction in the long term
use of methadone/Buprenorphine and naltrexone
448
what are the symptoms of LSD
psychosis, impaired judgement, panic attack, dilated pupils, hyperreflexia
449
what are rise effects of cocaine use
seizures coronary artery vasospasm ischaemic colitis hyperthermia QRS widening
450
what is a screening tool that is used for anorexia
SCOFF - make self sick after food - loss of control of food - one stone in last 3 months lost - food dominates life - fat perception
451
what bloods do you expect to see in someone with anorexia
everything will be reduced except growth hormone and cortisol which will be raised
452
what are complications of anorexia
refeeding syndrome infertility amenorrhoea osteoporosis
453
what are type A personality disorders
eccentric/odd - paranoid - schizotypal - schizoid
454
what are type B personality disorders
erratic/wild - narcissistic - histrionic - EUPD - antisocial
455
what are type C personality disorders
anxious - anankastic - OCPD - avoidant - dependent
456
what are psychological emergencies
neuroleptic malignant syndrome serotonin syndrome lithium toxicity alcohol overuse
457
what is it important to monitor when a child is taking methylphenidate
their growth charts as it can cause slow growth - 6 monthly also need to do baseline ECG as there is a risk of right bundle branch block
458
what are tics associated with
ASD ADHD PANDAs
459
what are simple tics
non-goal oriented movement
460
what are complex tics
echolalia coprolalia - verbal swearing copropraxia - middle finger
461
what is PANDAs
Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections - can cause OCD or tics after a strep infection
462
what should be done if a patient is on antidepressant medication before ECT is performed
should be reduced but not stopped