GP part 2 Flashcards

1
Q

what is irritable bowel syndrome

A

it is recurrent abdominal pain or discomfort which is associated with a change in stool frequency or form
the pain or discomfort may be relieved by defecation

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2
Q

what are symptoms of IBS

A

intestinal discomfort - pain, bloating, worse after eating, improved by opening bowels
bowel habit abnormalities - fluctuating
stool abnormalities - diarrhoea, constipation, passing mucus

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3
Q

what can IBS symptoms often be triggered or worsened by

A

Anxiety
Depression
Stress
Sleep disturbance
Illness
Medications
Certain foods
Caffeine
Alcohol

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4
Q

what are risk factors for IBS

A

physical or sexual abuse
PTSD
age <50
female sex
previous enteric infection
family history
family and job stress

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5
Q

how do you diagnose IBS

A

thorough history and examination to exclude red flags or any other pathology
FBC - anaemia
inflammatory markers
coeliac serology
faecal calprotectin
CA125 for ovarian cancer

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6
Q

what are the NICE clinical guidelines for a diagnosis of IBS

A

differentials need to be excluded and the patient should have at least 6 months of abdominal pain or discomfort with at least one of:
- pain or discomfort relieved by opening the bowels
- bowel habit abnormalities
- stool abnormalities
for a diagnosis the patients also require at least two of:
- straining, an urgent need to open bowels or incomplete emptying
- bloating
- worse after eating
- passing mucus

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7
Q

what lifestyle advice is given to patients who are diagnosed with IBS

A

drink enough fluids
regular small meals
adjusting fibre intake according to symptoms
limit caffeine, alcohol and fatty foods
low FODMAP diet, guided by dietician
probiotic supplements may be considered over the counter
reduce stress where possible
regular exercise

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8
Q

how is IBS treated

A
  1. first line is lifestyle management
  2. medications depend on symptoms - loperamide for diarrhoea, bilk forming laxatives for constipation, antispasmodics for cramps (mebeverine, alverine, hyoscine butylbromide)
  3. Linaclotide is a specialist secretor drug for constipation in IBS when first line laxatives are inadequate
  4. where symptoms remain uncontrolled think about other options: SSRI, low dose tricyclic antidepressants, CBT and specialist referral
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9
Q

what is a soft tissue injury

A

this is damage to muscles tendons and ligaments which may lead to pain, swelling and restricted mobility

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10
Q

what are types of soft tissue injury

A

sprains: stretching or tearing of ligaments
strains: muscle or tendon damage often occurring to the hamstring
contusions: bruises resulting from blunt force trauma that squashes muscle fibres underneath the skin without breaking the skin barrier
tendinitis: irritation or inflammation in a tenon that occurs due to overuse
bursitis: inflammation and swelling in the bursae

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11
Q

what are symptoms of a sprain

A

swelling
bruising
pain
inflammation
limited range of motion

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12
Q

what are symptoms of a strain

A

pain
muscle spasms and weakness
swelling
inflammation

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13
Q

what are symptoms of a contusion

A

pain and skin discolouration

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14
Q

what are symptoms of tendinitis

A

swelling
pain that worsens during activity

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15
Q

what are symptoms of bursitis

A

pain
swelling

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16
Q

what are causes of soft tissue injury

A

trauma - sudden impact or forceful movements can lead to soft tissue injury which might occur due to a fall, slip or sharp change in direction
overuse - repetitive movements or excessive strain on a particular muscle or joint
overloading - sudden increase in exercise intensity

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17
Q

how is soft tissue injury diagnosed

A

clinical history and examination
Xray
MRI

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18
Q

how are soft tissue injuries treated

A

rest, ice, compression and elevation
medications - analgesia
physical therapy
bracing or splinting
torn muscles, tendons, or ligaments may need surgery depending on how much of the tendon has torn and how severe it is

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19
Q

what is the classification of sprains

A

graded on severity
Grade 1: slight stretching and some damage to the fibres of the ligament
grade 2: partial tearing of the ligament. there is abnormal looseness in the joint when it is moved in certain ways
grade 3: complete tear of the ligament. may cause significant instability

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20
Q

what is lyme disease

A

it is an infection transmitted to humans following a bite from an infected tick

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21
Q

what causes lyme disease

A

a group of bacteria - Borrelia burgdoferis which is a spiral shaped bacteria

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22
Q

what are risk factors for Lyme disease

A

occupational and recreational exposure to woodland and fields
increased duration of tick attachment (over 36-48 hours)

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23
Q

what are complications of Lyme disease

A

severe neurological symptoms - chronic meningitis, encephalomyelitis, radiculopathies, peripheral neuropathy
facial palsy
lyme arthritis
persisting non specific symptoms such as fatigue, aches and pains, cognitive difficulties

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24
Q

How is Lyme disease diagnosed

A

clinical diagnosis of lyme disease in people with erythema migrans:
- spreading erythema with well defined edges
- round or oval shape
- red/purple in colour
- bulls eye appearance
in those without erythema migrans clinical presentation and laboratory testing will guide diagnosis

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25
how will Lyme disease present
bulls eye rash cognitive impairment ]fatigue fever and sweats headache malaise migratory joint or muscle aches and pain neck pain or stiffness paraesthesia swollen glands uveitis facial palsy or other nerve palsies unexplained radiculopathy
26
when does erythema migrans appear after being bitten by an infected tick
1-2 weeks post exposure typically and lasts several weeks untreated
27
what is the treatment for lyme disease
adults and children aged 12 and over: - doxycycline 100mg twice daily for 21 days - amoxicillin 100g three times daily for 21 days if doxycycline isnt suitable - azithromycin 3rd line in younger children still use doxycycline but it in dependent on body weight
28
what is a Jarisch - herxheimer reaction
it is a reaction that can present in 15% of people in the first 24 hours of treatment with any antibiotic for lyme disease. symptoms include fever, chills, muscle pains and headache
29
what is obesity defined as
it is a metabolic disease defined as an excessive accumulation of body fat that poses a risk to an individuals health
30
what are risk factors for developing obesity
poor diet and lack of physical activity underlying medical conditions - cushings, PCOS, hypothyroidism, GH deficiency medications - antidepressants and corticosteroids socio-economic status mental health - depression, eating disorders genetics - Prader Willi syndrome, Bardet Bieldl syndrome
31
what are clinical features of obesity
excess body fat weight above average for individuals height breathlessness sleep apnoea skin issues osteoarthritis hypertension diabetes hyperlipidaemia
32
what examinations should be done in practice in someone with obesity
measure BMI - weight divided by height squared central obesity by measuring waist to height ratio or waist circumference
33
what investigations should be done in a patient that is overweight
fasting blood glucose - obesity lipid profile - hyperlipidaemia LFT - non alcoholic fatty liver disease TSH - hypothyroidism U+E - chronic kidney disease dexamethasone suppression test for cushings ultrasound for PCOS
34
what is non surgical management for obesity
weight loss: target of 5 - 10% reduction lifestyle changes: healthy eating, alcohol recommendations, smoking cessation, therapy medications
35
what medications are offered to patients who are obese
Orlistat and liraglutide are the only medications approved by NICE for weight loss in the UK - Orlistat prevents absorption of dietary fat - Liraglutide is a GLP-1 analogue and delays gastric emptying and induces early satiety
36
what are side effects of liraglutide
nausea and vomiting diarrhoea pancreatitis thyroid cancer
37
what surgical measures are there for people who are obese
weight loss surgery in those who are severely obese (BMI > 40 or between 35-40 with co-morbidities) Bariatric surgery - Roux-en-Y gastric bypass, sleeve gastrectomy and gastric bypass
38
what is dumping syndrome
a group of symptoms caused by food rapidly emptying or being 'dumped' from the stomach into the small intestines. this results in undigested food within the small intestine that the body finds difficult to absorb symptoms include sweating, bloating, abdominal cramps, diarrhoea, nausea
39
what are complications of obesity
cardiovascular disease dyslipidaema diabetes stroke obstructive sleep apneoa cancer pancreatitis abnormal periods and infertility arthritis inflamed veins gout gallstones liver disease lung disease
40
what is otitis externa
it is inflammation of the external ear canal and can be either acute (less than 3 weeks) or chronic (more than three weeks)
41
what are infectious causes of otitis externa
bacterial - pseudomonal aeruginosa or staphylococcus aureus fungal - candida albicans and aspergillus niger
42
what are non infectious causes of otitis externa
atopic dermatitis psoriasis acne
43
what are risk factors for developing otitis externa
hot and humid climates swimming older age dermatological issues narrow ear canals (downs syndrome) previous ear surgery previous radiotherapy to the head and neck any history of immunosuppression including diabetes previous topical treatments for otitis externa or otitis media
44
how does otitis externa present
ear pain discharge itch hearing loss fever
45
what is seen on examination in someone with otitis externa
skin changes or tenderness at the tragus or pinna erythema, oedema and narrowing of the ear canal which may progress to complete occlusion serous or purulent discharge inflammation of the tympanic membrane which may be hard to visualise regional lymphadenopathy in pre/post auricular nodes conductive hearing loss secondary to obstruction
46
how is otitis externa diagnosed
clinical findings - history and exam swabs for microbiology
47
what is general advice given to someone with otitis externa
strict water precautions to keep the ear dry avoid itching or using cotton buds which further traumatise the ear canal
48
what is the medical management of otitis externa
topical antibiotic ear drops - antibiotic + steroid treatment is administered for a minimum of 7 days avoid aminoglycosides in patients with perforated tympanic membrane analgesia prescribed based off severity of pain ENT can do microsuction to remove infected debris from canal and insert an otowick
49
what are complications of otitis externa
necrotising otitis externa - infection spreads beyond the soft tissue of the ear canal resulting in osteomyelitis pinna or peri-auricular cellulitis
50
what are risk factors for developing complications with otitis externa
diabetes mellitis age over 65 recurrent otitis externa immunosuppression radiotherapy to head or neck
51
what is otitis media
it is the name given to an infection in the middle ear - space that sits between the tympanic membrane and the inner ear
52
what is the cause of otitis media
bacterial infection which enters from the back of the throat through the eustachian tube
53
what bacteria cause otitis media
streptococcus pneumoniae - most common haemophilus influenzae morazella catarrhalis staphylococcus aureus
54
how does otitis media present
ear pain reduced hearing in the affected ear general symptoms of upper airway infection: fever, cough, coryzal symptoms, sore throat, general malaise balance issues and vertigo if tympanic membrane is perforated there can be discharge
55
what is seen on examination in otitis media
bulging, inflamed red tympanic membrane if there is perforation you may see discharge in the ear canal and a hole in the tympanic membrane
56
what is the management of otitis media
refer for specialist assessment and admission in infants younger than 3 months with a temp above 38, or 3-6 months with a temp higher than 39 most cases resolve without antibiotics - normally within 3 days but can last a week give simple analgesia to help with pain and fever
57
what are the options for prescribing antibiotics in otitis media
1. immediate antibiotics - initial presentation with significant co-morbidities, systemically unwell or immunocompromised 2. delayed antibiotics - collected and used after 3 days if the symptoms havent improved or have gotten worse first line choice of antibiotic is amoxicillin 5 days 3. no antibiotics
58
what are complications of otitis media
Otitis medial with effusion Hearing loss (usually temporary) Perforated eardrum Recurrent infection Mastoiditis (rare) Abscess (rare)
59
what is fibromyalgia
it is a chronic health condition that causes pain and tenderness throughout the body which occurs in flares. It causes musculoskeletal pain and fatigue
60
who is more likely to be diagnosed with fibromyalgia
people assigned female at birth people older than 40
61
what are symptoms of fibromyalgia
muscle pain or tenderness fatigue face and jaw pain - temporomandibular joint disorders headaches and migraines digestive issues including diarrhoea and constipation bladder control issues memory issues anxiety depression insomnia and other sleep disorders
62
what are risk factors for fibromyalgia
age - over 40 sex - more common in women living with other chronic illnesses infections stress trauma
63
what can trigger a fibromyalgia flare up
emotional stress - job, finance, social life changes in daily routing changes in diet or nutrition hormonal changes not getting enough sleep or change in sleep weather or temperature changes illness starting new medication or treatments
64
how is fibromyalgia diagnosed
history and examination diagnosis of exclusion - may do bloods and other tests to rule out other causes of fatigue
65
how is fibromyalgia treated
over the counter or prescription pain medication exercises like stretches or strength training sleep therapy cognitive behavioural therapy stress management antidepressants
66
what are the four stages of treating fibromyalgia
non pharmacological treatments - exercise and strength training psychological treatments pharmacological treatments daily functioning - occupational therapist
67
what is osteoarthritis
it is progressive degenerative joint disorder, referred to as a dysfunctional wear and repair process within a joint
68
what are the most common joints affected by osteoarthritis
knees hips hands
69
what is the pathophysiology of osteoarthritis
chondrocytes are responsible for maintaining the homeostasis between synthesis and degradation of the extracellular matrix within articular cartilage. Over time, continuous wear or trauma to the joint causes local inflammation and stimulation of chondrocytes to release degradative enzymes. these enzymes break down collagen and proteoglycan and ultimately destroy the articular cartilage
70
what are risk factors for developing osteoarthritis
increasing age female sex obesity less commonly articular congenital deformities or trauma to the joint
71
what are symptoms of osteoarthritis
joint pain stiffness: typically worse after activity and at the end of the day limitation in day to day activities in some cases patients will experience referred pain
72
what would you find on examination in someone with osteoarthritis
reduced active and passive range of movement secondary to pain tenderness of the the joint lines crepitus on movement
73
how does osteoarthritis of the hand present
sparing of the metacarpophalangeal joints bony enlargements of the proximal interphalangeal joints known as bouchards nodes bony enlargement of the distal interphalangeal joints known as heberdens nodes squaring of the first carpometacarpal joint (base of the thumb) reduced functional movement
74
what investigations should be done for someone with osteoarthritis
bodyweight and BMI labs - serum CRP/ESR imaging - Xray
75
what are the Xray changes seen in osteoarthritis
loss of joint space osteophytes subchondral sclerosis subchondral cysts
76
When does NICE advise that osteoarthritis be diagnosed clinically
if a person meets the criteria: over 45 and has activity related joint pain and has either no morning joint related stiffness or morning stiffness that lasts no longer than 30 minutes
77
what is the conservative management for osteoarthritis
education and advice about the condition exercise: muscle strengthening and general aerobic fitness weight loss (if overweight or obese)
78
what is the medical management of osteoarthritis
First line: topical NSAIDS second line: paracetamol and topical analgesia third line: NSAID, paracetamol and topical capsaicin fourth line: opioid, NSAID, paracetamol and topical capsaicin intra-articular corticosteroid injection can be offered for acute exacerbation of pain despite regular use of analgesia
79
what is the surgical management of osteoarthritis
joint replacement - arthroplasty fusion of the joint - arthrodesis
80
what is peripheral arterial disease
this refers to the narrowing of the arteries supplying the limbs and the periphery, reducing the blood supply to these areas. It usually refers to the lower limbs, resulting in symptoms of claudication
81
what is intermittent claudication
it is a symptoms of ischaemia in a limb, occurring during exertion and relieved by rest. It is typically a crampy, achy pain in the calf, thigh or buttock muscles associated with muscle fatigue when walking beyond a certain intensity
82
what is critical limb ischaemia
it is end stage peripheral arterial disease, where there is an inadequate supply of blood to a limb to allow it to function normally at rest. there is a significant risk of losing the limb
83
what are the features of critical limb ischaemia
pain at rest non healing ulcers gangrene pain is worse at night when the leg is raised as gravity no longer helps to pull blood into the foot
84
what is acute limb ischaemia
it refers to a rapid onset of ischaemia in a limb, typically it is due to thrombosis blocking the arterial supply of a distal limb, similar to a thrombus blocking a coronary artery in myocardia infarction
85
what do atheromatous plaques lead to in vessels
stiffening of artery walls leading to hypertension and strain on the heart stenosis leading to reduced blood flow plaque rupture resulting in a thrombus
86
what are non modifiable risk factors for atherosclerosis
older age family history male
87
what are modifiable risk factors for atherosclerosis
smoking alcohol consumption poor diet low exercise/sedentary lifestyle obesity poor sleep stress
88
what are medical co-morbidities which can increase the risk of atherosclerosis
diabetes hypertension chronic kidney disease inflammatory conditions such as rheumatoid arthritis atypical antipsychotic medications
89
what are the features of acute limb ischaemia
pain pallor pulseless paralysis paraesthasia perishingly cold
90
what is Leriche syndrome
it occurs with occlusion of the distal aorta or proximal common iliac artery. There is a clinical triad of: thigh/buttock claudication absent femoral pulses male impotence
91
what peripheral pulses may be weaker in someone with peripheral arterial disease
radial brachial carotid abdominal aorta femoral popliteal posterior tibial dorsalis pedis
92
what are signs of arterial disease on inspection
skin pallor cyanosis dependent rubor (deep red colour when limb is lower than the rest of the body) muscle wasting hair loss ulcers poor wound healing gangrene
93
when examining someone with peripheral arterial disease what may you see
reduced skin temperature reduced sensation prolonged capillary refill time (>2 seconds) changes during buergers test
94
what are arterial ulcers typically caused by
ischaemia secondary to an inadequate blood supply
95
what are the features of an arterial ulcer
smaller than venous deeper than venous well defined borders punched out appearance occur peripherally have reduced bleeding are painful
96
what are venous ulcers typically caused by
impaired drainage and pooling of blood in the legs
97
what are the features of venous ulcers
occur after a minor leg injury are larger than arterial ulcers more superficial than arterial ulcers irregular, gently sloping borders affect the gaiter area of the leg (mid-calf down) less painful than arterial ulcers occur with other signs of chronic venous insufficiency
98
what investigations should be done on someone with peripheral arterial disease
ankle-brachial pressure index duplex ultrasound angiography
99
what is the conservative management for someone with peripheral arterial disease
lifestyle changes - manage modifiable risk factors exercise training
100
what medical treatments are there for peripheral arterial disease
atorvastatin 80mg clopidogrel 75mg once daily naftidrofuryl oxalate (5-HT receptor antagonist that acts as a peripheral vasodilator)
101
what surgical options are there for peripheral arterial disease
endovascular angioplasty and stenting endarterectomy - cutting vessel open and removing the atheromatous plaque bypass surgery
102
what is the management of critical limb ischaemia
urgent referral to the vascular team - endovascular angioplasty and stenting - endarterectomy - bypass surgery - amputation
103
what are risk factors or chronic venous insufficiency
age immobility obesity prolonged standing deep vein thrombosis
104
what is chronic venous insufficiency
this occurs when blood does not efficiently drain from the legs back to the heart. Usually this is a result of damage from the valves inside the legs
105
what are symptoms of chronic venous insufficiency
skin changes - haemosiderin staining venous eczema due to chronic inflammatory response in the skin lipodermatosclerosis atrophie blanche - porcelain white scar tissue on skin cellulitis poor healing after injury skin ulcers pain
106
what is the management for chronic venous insufficiency
1. keeping the skin healthy - monitor skin health, regular use of emollients, topical steroids to avoid flares of venous eczema, very potent topical steroids to treat flares of lipodermatosclerosis 2. improving venous drainage - wt loss, keeping legs elevated and compression stockings 3. management of complications- antibiotics, analgesia and wound care
107
what is polymyalgia rheumatica
it is an inflammatory condition that causes pain and stiffness in the shoulders, pelvic girdle and neck there is often a strong association with giant cell arteritis
108
how does polymyalgia rheumatica present
may have relatively rapid onset of symptoms from days to weeks pain and stiffness of the shoulders, pelvic girdle and the neck worse in the morning worse after rest or inactivity interferes with sleep can take at least 45 minutes to ease in the morning somewhat improves with activity can have systemic symptoms - wt loss, fever, fatigue muscle tenderness carpel tunnel syndrome peripheral oedema
109
what are differential diagnosis for polymyalgia rheumatica
Osteoarthritis Rheumatoid arthritis Systemic lupus erythematosus Statin-induced myopathy Myositis (e.g., polymyositis) Cervical spondylosis Adhesive capsulitis (frozen shoulder) Hyperthyroidism or hypothyroidism Osteomalacia Fibromyalgia Lymphoma or leukaemia Myeloma
110
how is polymyalgia rheumatica diagnosed
based on clinical presentation, its response to steroids and excluding differentials labs - FBC, U+E, LFT, calcium, serum protein electrophoresis (myeloma), TSH, creatinine kinase (myositis), rheumatoid factor, urine dip also consider: antinuclear antibodies for SLE anti-cyclic citrullinated peptide (CCP) for RA urine bence jones for myeloma chest X ray
111
how is polymyalgia rheumatica treated
steroids: 15mg prednisolone daily initially and then follow up after 1 week (patients with PR should have a dramatic improvement in a week) treatment with steroids usually lasts for 1-2 years and then follow the reducing regime of prednisolone
112
what is the reducing regime of prednisolone that NICE suggests following
15mg until symptoms are fully controlled then 12.5mg for 3 weeks then 10mg for 4-6 weeks then reducing by 1mg every 4-8 weeks
113
what are the additional managements for patients on long term steroids
Dont STOP Dont - steroid dependence occurs after three weeks of treatment, and abruptly stopping risks adrenal crisis S- sick rules, steroids doses need to be increased if the patient becomes unwell T- treatment card, patients should carry a card which tells others they are steroid dependent O- Osteoporosis prevention may be required with bisphosphonates and calcium and vit D P- proton pump inhibitors are considered for gastro protection
114
what is the blood supply of the prostate gland
the inferior vesical (primary), middle rectal and internal pudendal arteries
115
what is the nervous innervation of the prostate gland
sympathetic = hypogastric nerve parasympathetic = pelvic nerve
116
what are risk factors for the development of prostate cancer
age over 50 black ethnicity family history of prostate cancer family history of other heritable cancers such as breast or colorectal high levels of dietary fat
117
where does prostate cancer spread to
lymph nodes and bones
118
what are symptoms of prostate cancer
Lower urinary tract symptoms - frequency, urgency, nocturia, hesitancy, dysuria, post void dribbling haematuria haematospermia systemic symptoms - weight loss, weakness, fatigue bone pain
119
what might you find on clinical examination with prostate cancer
on a DRE - asymmetrical prostate, nodular prostate, indurated prostate
120
what investigations should be done in someone with suspected prostate cancer
Serum prostate specific antigen U+E FBC testosterone levels LFTs MRI and biopsy DEXA, CT and PMSA PET to look for metastasis
121
what grading system is used to grade prostate cancer
the gleason grading system the TNM staging is also used for prostate cancer to help stage the cancer
122
how is the gleason score calculated
by adding the two most prevalent differentiation patterns together
123
what does a gleason score of under 6 mean
its a stage 1 tumour low grade, sometimes clinically insignificant
124
what does a gleason score of 7 mean
7 (3+4) is stage 2, intermediate grade 7 (4+3) is stage three, intermediate grade tumour but less favourable outcome than 3+4
125
what does a gleason score of 8 mean
stage 4, high grade tumour
126
what does a gleason score of 9-10 mean
stage 5, highest grade tumour
127
what is used as the first line investigation for suspected localised prostate cancer
multiparametric MRI
128
how are the results of a multiparametric MRI used to report on prostate cancer
reported on a Likert scale and scored as: 1 – very low suspicion 2 – low suspicion 3 – equivocal 4 – probable cancer 5 – definite cancer
129
what are the options for getting a prostate biopsy
transrectal ultrasound guided biopsy transperineal biopsy
130
what are common causes of a raised PSA
Prostate cancer Benign prostatic hyperplasia Prostatitis Urinary tract infections Vigorous exercise (notably cycling) Recent ejaculation or prostate stimulation
131
how is ow risk prostate cancer managed
PSA <10, gleason score <6, T1-2a - watchful waiting with regular DRE and PSA tests, if anything significantly changes then palliative care may be initiated - active surveillance with regular DRE, PSA and often biopsies annually, if anything changes then active treatment may be initiated
132
how is intermediate risk prostate cancer managed
PSA 10-20, OR gleason score 7/T2B stage - Active surveillance - surgery: removal of the prostate - radiotherapy: external beam radiotherapy, or brachytherapy
133
what is the treatment for high risk prostate cancer
PSA >20 OR gleason score 8-10/T2c or above - active surveillance - surgery: radical prostatectomy - radiotherapy: external beam radiotherapy - Hormone therapy: GnRH therapy, androgen receptor blockers, androgen blockers targeting the adrenal glands, bilateral orchiectomy, oestrogen therapy
134
what are side effects of hormone therapy for prostate cancer
hot flushes decreased bone density fractures low libido erectile dysfunction altered lipids - gnaecomastia fatigue
135
what is psoriasis
it is a chronic autoimmune condition that causes recurrent symptoms of psoriatic skin lesions
136
what are patches of psoriasis
they are dry, flaky, scaly, faintly erythematous skin lesions that appear in raised and rough plaques, commonly over the extensor surfaces of the elbows, knees and scalp
137
what causes skin changes in psoriasis
rapid generation of new skin cells, resulting in an abnormal buildup and thickening of skin in those areas
138
what is plaque psoriasis
it causes thickened erythematous plaques with silver scales, commonly seen on extensor surfaces and the scalp this is the most common form of psoriasis in adults
139
what is guttate psoriasis
it is common in children it causes main raised small papules across the trunk and the limbs. They are mildly erythematous and can be scaly. Over time they can turn into plaques
140
what is Guttate psoriasis often triggered by
streptococcal throat infection stress medications
141
what is pustular psoriasis
it is where pustules form under areas of erythematous skin. the pus is non infectious - should be treated as medical emergency and those with it should require hospital admission
142
what is erythrodermic psoriasis
it is a rare form of psoriasis with extensive erythematous inflamed areas covering most of the surface area of the skin the skin comes away in large patches resulting in raw exposed areas - treated as a medical emergency and patients require admission
143
what are the types of psoriasis
plaque psoriasis guttate psoriasis pustular psoriasis erythrodermic psoriasis
144
What are signs which are suggestive of psoriasis
Auspitz sign: small points of bleeding when plaques are scraped off Koebner phenomenon: development of psoriatic lesions to areas of skin affected by trauma residual pigmentation of the skin after lesions resolve
145
how is psoriasis managed
dependent on the severity of the condition 1. topical steroids 2. topical vitamin D analogues (calcipotriol) 3. topical dithranol 4. topical calcineurin inhibitors (adults) 5. phototherapy with narrow band ultraviolet B light
146
what is given in psoriasis if topical treatments fail
may be started in systemic treatment (unlicensed in children) which might include methotrexate, cyclosporin, retinoids or biologics there are two products that are both a potent steroid and vitamin D analogue (not licensed in children and guided by specialist) which are dovobet and enstilar
147
what is psoriasis associated with
nail psoriasis psoriatic arthritis psychosocial implications - depression and anxiety obesity hyperlipidaemia hypertension type 2 diabetes
148
what organism causes syphilis
an organism called Treponema pallidum, a spirochete
149
what is the incubation period of syphilis
between initial infection and symptoms is about 21 days
150
how is syphilis transmitted
sexually transmitted infection - oral vaginal or anal sex vertical transmission IV drug use blood transfusions and other transplants
151
what are the stages of syphilis
primary secondary latent tertiary neurosyphilis
152
what is primary syphilis
this involves a painless ulcer called a chancre at the original site of infection
153
what is secondary syphilis
systemic symptoms, particularly of the skin and mucous membranes. These symptoms can resolve after 3 – 12 weeks and the patient can enter the latent stage.
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what is latent syphilis
after the secondary stage of syphilis, where symptoms disappear and the patient becomes asymptomatic despite still being infected. Early latent syphilis occurs within two years of the initial infection, and late latent syphilis occurs from two years after the initial infection onwards.
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what is tertiary syphilis
can occur many years after the initial infection and affect many organs of the body, particularly with the development of gummas and cardiovascular and neurological complications.
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what is neurosyphilis
this occurs if the infection enters the central nervous system and presents with neurological symptoms
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what are symptoms of primary syphilis
A painless genital ulcer (chancre). This tends to resolve over 3 – 8 weeks. Local lymphadenopathy
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what are symptoms of secondary syphilis
Maculopapular rash Condylomata lata (grey wart-like lesions around the genitals and anus) Low-grade fever Lymphadenopathy Alopecia (localised hair loss) Oral lesions
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what are symptoms of tertiary syphilis
Gummatous lesions (gummas are granulomatous lesions that can affect the skin, organs and bones) Aortic aneurysms Neurosyphilis
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what are symptoms of neurosyphilis
Headache Altered behaviour Dementia Tabes dorsalis (demyelination affecting the spinal cord posterior columns) Ocular syphilis (affecting the eyes) Paralysis Sensory impairment
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what is an Argyll-Robertson pupil
it is a specific finding of neurosyphilis. It is a constricted pupil that accommodates when focusing on a near object, but doesnt react to light
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how is syphilis diagnosed
Antibody testing for T.pallidum antibodies referral to GUM clinic samples from infection site can be tested to confirm presence with dark field microscopy and PCR Rapid plasma reagin and venereal disease research laboratory tests are two non specific but sensitive tests used to assess for active syphilis - assesses the quantity of antibodies
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what is the management of syphilis
GUM referral - screening for other STIs, advice about avoiding sexual activity, contact tracing single deep IM dose of benzathine benzylpenicillin is the standard treatment - other regimes and types of penicillin are used in late and neurosyphilis. Ceftriaxone, amoxicillin and doxycycline are alternatives
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what is acute rhinosinusitis
acute inflammation of the mucosal linings of the nasal passage (rhinitis) and paranasal sinuses (sinusitis)
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what causes of acute rhinosinusitis
most common causes are viral organisms such as rhinovirus, influenza or adenovirus however they can be caused by bacterial organisms such as s.pneumoniae, H. influenzae or M.catarrhallis allergic precipitants that can cause rhinosinusitis are dust, pollen and cat or dog hair
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what are the paranasal sinuses
they are hollow spaces within the bones of the face, arranges symmetrically around the nasal cavity
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what are the 4 paranasal sinuses
frontal sinus - within the frontal bone, most superior of the paranasal sinuses ethmoid sinus - in the ethmoid bone and are made up of 3 separate cavities sphenoid sinus - in the sphenoid bone, opening out into the nasal cavity maxillary sinus - largest, located laterally and slightly inferiorly to the nasal cavities and drain into them
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what are the main risk factors for developing acute rhinosinusitis
cigarette smoking exposure air pollution anatomical variations such as septal deviation, nasal polyps or sinus hypoplasia atopic disease such as asthma or hayfever
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what are the clinical features of acute rhinosinusitis
symptoms lasting less than 12 weeks sudden onset of two or more of the following symptoms: nasal obstruction discoloured nasal discharge facial pain or pressure altered sense of smell
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what are symptoms which might indicate bacterial rhinosinusitis
severe local pain discoloured discharge fever worsening after initial improvement (post viral)
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what are differential diagnosis for acute rhinosinusitis
viral upper respiratory tract infection allergic rhinitis facial pain syndromes nasal foreign body
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how is acute rhinosinusitis diagnosed
clinical symptoms and history can have imaging such as CT if complications are suspected skin prick testing for allergy may be appropriate in patients with recurrent episodes
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how is acute rhinosinusitis managed
most cases are managed in the community and do not require antibiotics - for uncomplicated cases treat with simple analgesia, nasal douche and decongestants - for those with acute bacterial rhinosinusitis antibiotics will be required if there is no improvement after 7-14 days of treatment or the presence of red flag symptoms then refer to ENT
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what are red flag symptoms for rhinosinusitis
eye signs - swelling, erythema, displaced globe, visual changes, ophthalmoplegia severe unilateral headache, bilateral frontal headache or frontal swelling neurological signs or reduced consciousness
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what is specialist management of rhinosinusitis
nasal endoscopy - look at any structural abnormalities or pathology CT scan of paranasal sinuses severe infections may require admission with oral steroids, IV antibiotics and surgery
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what are complications of acute rhinosinusitis
peri-orbital cellulitis osteomyelitis - can lead to penetration into the skull Potts puffy tumour - osteomyelitis of the frontal sinus leading to soft boggy swelling over the overlaying tissue on the forehead
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what are the tonsils a part of in the oropharynx
Waldeyers ring - ring shapes lymphoid tissue in the oropharynx which consists of four main groups of tonsils: adenoid, tuba, palatine and lingual (in clinical practice tonsilitis = palatine)
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what are causes of tonsillitis
Viral causes Bacterial causes non infectious causes
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what are the common viral causes of tonsilitis
rhinovirus - most common coronavirus parainfluenza epstein barr virus
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what are common bacterial causes of tonsilitis
Group A beta haemolytic strep (pyogenes) - most common haemophilus influenzae moraxella catarrhalis
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what are non infectious causes of tonsilitis
Gastroesophageal reflux disease physical irritation (nasogastric tubes)
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what are the typical symptoms of tonsilitis
sore throat cough coryzal prodrome dysphonia pyrexia pain and malaise dysphagia halitosis
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what would be seen on examination of someone with tonsilitis
fever swollen erythematous palatine tonsils cervical lymphadenopathy tonsils covered with exudate peritonsillar abscess - usually a complication of acute tonsilitis
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what are differential diagnosis for tonsilitis
epiglottitis infection mononucleosis squamous cell carcinoma
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what investigations should be done for tonsilitis
acute episodes can be diagnosed using clinical features alone - key to determine whether its viral or bacterial which is done using the help of the CENTOR and FeverPAIN criteria
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what is the CENTOR criteria
used to determine if its viral or bacterial looking at symptoms of tonsilitis - tonsillar exudate - tender anterior cervical lymphadenopathy - history of fever (>38) - absence of cough score of 0-2 has a low probability of a bacterial infection and should be managed conservatively score of 3-4 has a higher probability of bacterial infection and should be treated with antibiotics
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what is the FeverPAIN score
it is a criteria which consists of five symptoms of acute tonsilitis each scoring 1 point, indicating the likelihood of a bacterial tonsillitis
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what are the criteria of the FeverPAIN score
Fever (during previous 24 hours) Purulence (pus on tonsils) Attend rapidly (within 3 days after symptom onset) severely Inflamed tonsils No cough or coryza A score of 0-2 has a low probability of bacteria infection and should be managed conservatively a score of 3-4 has a higher change of bacterial infection and is treated with antibiotics
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what lab tests can be done for tonsilitis
they are not routinely performed, however they may be useful in confirming bacterial infection with other conditions such rheumatic fever and heart disease - throat swab for culture - rapid streptococcal antigen test - monospot test for EBV
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what is the acute management of tonsilitis
supportive: hydration, fluids, ibuprofen plus paracetamol and rest prescribe antibiotics if suspected bacterial infection - phenoxymethylpenicillin for 10 days - if allergic to penicillin clarithromycin or erythromycin for 5 days
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what is chronic management of tonsillitis
NICE advises that certain patients with recurrent episodes of tonsillitis can be referred for tonsillectomy: - more than 7 documented, adequately treated, sore throat episodes in 1 year - more than 5 episodes in 2 years - more than 3 episodes in 3 years - for whom there is no other explanation for recurrent symptoms
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what are complications of tonsillitis
otitis media - most common sinusitis peritonsillar abscess scarlet fever
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what are the four muscles in the rotator cuff
subscapularis supraspinatus infraspinatus teres minor
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what are the clinical findings in a rotator cuff injury
pain - insidious onset, often night pain, exacerbated by overhead activities, in traumatic tear the pain and weakness are acute weakness - loss of active range of motion with greater passive range of motion
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what would be seen on examination of someone with a rotator cuff injury
additional weakness on the resisted movement of the rotator cuff muscles
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how are rotator cuff injuries diagnosed
clinical history and examination imaging - X-rays to look for any tear, tendonitis etc. Ultrasound and MRI
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how is rotator cuff injury managed
non surgical - physiotherapy, activity modification, NDAIDs, corticosteroid injections surgical- repair the rotator cuff +/- subacromial decompression
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what is tennis/golfers elbow
it is an overuse syndrome of the lateral epicondyle (tennis elbow) and medial epicondyle (golfers elbow)
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what is an overuse injury
it is due to eccentric overload at the common extensor tendon leading to tendinitis and inflammation at the origin of the ECRB commonly known as tennis elbow - same happens for golfers elbow just at the flexor pronator mass origin
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what are the clinical findings of tennis/golfers elbow
pain - insidious onset, is localised over the medial or lateral epicondyle, worse with wrist and forearm motion and gripping
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what would you see on examination of someone with tennis/golfers elbow
point tenderness distal and anterior to the medial epicondyle (golfers) and tenderness at the ECRB insertion into the lateral epicondyle (tennis) tennis elbow: resisted wrist extension with the elbow fully extended golfers: pain with resisted forearm pronation and wrist flexion
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what is the management of tennis/golfers elbow
non surgical; rest, ice, physiotherapy, activity modification, bracing and NSAIDS surgical: open debridement of the origin
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what is urinary incontinence
it refers to the loss of control of urination
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what are the two types of urinary incontinence
urge and stress
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what is urge incontinence
it is overactivity of the detrusor muscle of the bladder (overactive bladder)
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what are symptoms of urge incontinence
sudden feeling of the urge to pass urine having to rush to the bathroom and not arriving before urination occurs
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what causes stress incontinence
the pelvic floor consists of a sling of muscles that supports the contents of the pelvic floor. When the muscles of the pelvic floor are weak, the canals become lax and the organs are poorly supported
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what is stress incontinence
incontinence due to weakness of the pelvic floor and sphincter muscles allowing urine to leak out at times of increased pressure on the bladder such as laughing, coughing or surprised
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what is mixed incontinence
this is a combination of urge and stress incontinence - crucial to identify which is the bigger issue and treat that one first
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what is overflow incontinence
this can occur when there is chronic urinary retention due to an obstruction to the outflow of urine. Chronic urinary retention results in overflow of urine and the incontinence occurs without the urge to pass urine
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what can cause overflow incontinence
anticholinergic medications fibroids pelvic tumours neurological conditions - MS, diabetic neuropathy, spinal cord injuries
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what are risk factors for urinary incontinence
Increased age Postmenopausal status Increase BMI Previous pregnancies and vaginal deliveries Pelvic organ prolapse Pelvic floor surgery Neurological conditions, such as multiple sclerosis Cognitive impairment and dementia
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what modifiable risk factors can contribute to incontinence
Caffeine consumption Alcohol consumption Medications Body mass index (BMI)
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what might be seen on examination of someone with incontinence
pelvic organ prolapse atrophic vaginitis urethral diverticulum pelvic masses leakage from urethra if patient is asked to cough also look for strength of pelvic muscle contraction during bimanual and grade on the modified oxford grading system
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what are the grades of pelvic muscle contractions measured using the modified oxford grading system
0: No contraction 1: Faint contraction 2: Weak contraction 3: Moderate contraction with some resistance 4: Good contraction with resistance 5: Strong contraction, a firm squeeze and drawing inwards
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how is incontinence investigated
a bladder diary urine dipstick testing post void residual bladder volume urodynamic testing - for urge incontinence not responding to treatment
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what is urodynamic testing
it is a way of assessing the presence and severity of urinary symptoms - a thin catheter is inserted into the bladder and another into the rectum. They measure the pressures in the bladder and rectum and compare them
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what does cystometry measure
measures the detrusor muscle contraction and pressure
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what does uroflowmetry measure
the flow rate
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what is the leak point pressure
point at which the bladder pressure results in leakage of urine. The patient is asked to cough, move or jump when the bladder is filled to various capacities. This assesses for stress incontinence.
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what is video urodynamic testing
filling the bladder with contrast and taking xray images as the bladder is emptied. Theses are only performed where necessary and not a routine part of urodynamic testing.
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how is stress incontinence managed
lifestyle advice: avoid caffeine, diuretics and overfilling of the bladder. Avoid excessive exercise or restricted fluid intake. Weight loss if appropriate supervised pelvic floor exercises for at least three months before considering surgery surgery duloxetine - SNRI antidepressant
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what are the surgical options for treatment of stress incontinence
tension free vaginal tape - mesh sling under the urethra autologous sling procedures - strip of facia from patients abdominal wall is used colposuspention - stitches connecting the anterior vaginal wall and the pubic symphysis around the urethra intramural urethral bulking - injections around the urethra to reduce the diameter and add support
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what surgical intervention is used where stress incontinence is caused by a neurological disorder or other surgical methods have failed
artificial urinary sphincter - pump inserted into the labia that inflates and deflates a cuff around the urethra allowing women to control their continence manually
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what is the management of urge incontinence
bladder retraining for at least 6 weeks is first line anticholinergic medication (oxybutynin, tolterodine) mirabegron invasive procedures
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what are side effects of anticholinergic medication
dry mouth dry eyes urinary retention constipation postural hypotension cognitive decline, memory issues and worsening of dementia
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what is Mirabegron
it is used as an alternative treatment for urge incontinence with less anticholinergic burden
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what condition is mirabegron contraindicated in
uncontrolled hypertension as it works as a beta 3 agonist leading to sympathetic nervous stimulation and raising blood pressure
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what are the invasive options for treatment of overactive bladder
Botulinum toxin type A percutaneous sacral nerve stimulation augmentation cystoplasty - using bowel tissue to enlarge the bladder urinary diversion
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what is reactive arthritis
it involves synovitis in one or more joint in response to an infective trigger. Typically it causes acute monoarthritis, affecting a single joint.
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what are the most common triggers of reactive arthritis
gastroenteritis STI - chlamydia and gonorrhoea (typically causes septic)
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what is the classic triad of reactive arthritis
bilateral conjunctivitis anterior uveitis urethritis arthritis cant see, cant pee, cant climb a tree - can also cause circinate balanitis (dermatitis of the head of the penis)
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how is reactive arthritis diagnosed
1st you need to exclude septic arthritis and antibiotics may be given until septic arthritis is excluded - require joint aspiration sent for MC+S, as well as crystal examination
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what is the management of reactive arthritis
treatment of the triggering infection NSAIDS steroid injections into the affected joints systemic steroids may be required, particularly where multiple joints are affected
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what is urticaria
it is also known as hives. It is small, itchy lumps that appear on the skin. They may be associated with a patchy erythematous rash. They may be localised to a certain area or widespread
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what is the pathophysiology of urticaria
Urticaria are caused the release of histamine and other pro-inflammatory chemicals by mast cells in the skin. This may be part of an allergic reaction in acute urticaria or an autoimmune reaction in chronic idiopathic urticaria.
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what are causes of acute urticaria
Allergies to food, medications or animals Contact with chemicals, latex or stinging nettles Medications Viral infections Insect bites Dermatographism (rubbing of the skin)
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what is chronic urticaria
it is an autoimmune condition where autoantibodies target mast cells and trigger them to release histamine and other chemicals. It can be sub classified depending on the cause
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what are the different types of chronic urticaria
Chronic idiopathic urticaria Chronic inducible urticaria Autoimmune urticaria
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what is chronic idiopathic urticaria
recurrent episodes of chronic urticaria without a clear underlying cause or trigger.
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what is chronic inducible urticaria
describes episodes of chronic urticaria that can be induced by certain triggers, such as: Sunlight Temperature change Exercise Strong emotions Hot or cold weather Pressure (dermatographism)
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what is autoimmune urticaria
chronic urticaria associated with an underlying autoimmune condition, such as systemic lupus erythematosus.
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what is the management of urticaria
antihistamines are the main treatment - fexofenadine oral steroids may be considered as short courses for severe flares in very problematic cases referral to specialist may be required and consider treatment with: Anti-leukotrienes such as montelukast Omalizumab, which targets IgE Cyclosporin
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what is syncope
it is the event of temporarily losing consciousness due to a disruption of blood flow to the brain, often leading to a fall
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what is a vasovagal episode
problem with the autonomic nervous system regulating blood to the brain. When the vagus nerve receives a strong stimulus it can stimulate the parasympathetic nervous system. this leads to a drop in blood pressure and hypoperfusion of the brain tissue, causing a faint
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what are prodrome symptoms of a vasovagal syncope
Hot or clammy Sweaty Heavy Dizzy or lightheaded Vision going blurry or dark Headache
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what might happen during a vasovagal episode
Suddenly losing consciousness and falling to the ground Unconscious on the ground for a few seconds to a minute as blood returns to their brain There may be some twitching, shaking or convulsion activity, which can be confused with a seizure
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what are primary causes of syncope (simple fainting)
Dehydration Missed meals Extended standing in a warm environment, such as a school assembly A vasovagal response to a stimuli, such as sudden surprise, pain or the sight of blood
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what are secondary causes of syncope
Hypoglycaemia Dehydration Anaemia Infection Anaphylaxis Arrhythmias Valvular heart disease Hypertrophic obstructive cardiomyopathy
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what are key details in someones history would point you towards syncope
Features that distinguish a syncopal episode from a seizure After exercise? Syncope after exercise is more likely to be secondary to an underlying condition. Triggers? Concurrent illness? Do they have a fever or signs of infection? Injury secondary to the faint? Do they have a head injury? Associated cardiac symptoms, such as palpitations or chest pain? Associated neurological symptoms? Seizure activity? Family history, particularly cardiac problems or sudden death?
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what examinations should be performed if someone comes in after syncope
Are there any physical injuries as a result of the faint, for example a head injury? Is there a concurrent illness, for example an infection or gastroenteritis? Neurological examination Cardiac examination, specifically assessing pulses, heart rate, rhythm and murmurs Lying and standing blood pressure
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what investigations should you do if someone comes in after a syncope episode
ECG, particularly assessing for arrhythmia and the QT interval for long QT syndrome 24 hour ECG if paroxysmal arrhythmias are suspected Echocardiogram if structural heart disease is suspected Bloods, including a full blood count (anaemia), electrolytes (arrhythmias and seizures) and blood glucose (diabetes)
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what is the management of vasovagal syncope
need to exclude other pathology once vasovagal episode is diagnosed, reassurance and simple advice can be given: - avoid dehydration - avoid missing meals - avoid standing for long periods of time - when experiencing prodromal symptoms such as sweating and dizziness, sit or lie down and have some water or something to eat
254
what are varicose veins
they are dilated tortuous veins which mainly occurs in the superficial venous system in the legs
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what is the pathophysiology of varicose veins
varicose veins develop due to the incompetence of the one way valves, leading to leakage, retrograde flow and consequently pooing of blood in the superficial venous system additionally the thinner weaker walls of the superficial veins make them more prone to the effects of the high pressure build up of blood leading to distension and tortuosity o the affected segment, leading to bulging of the skin over the affected vein
256
what are causes of varicose veins
mostly idiopathic secondary causes can be due to venous outflow obstruction due to intravascular (DVT) or extravascular (pelvic mass) reasons progesterone and oestrogen are also believed to have vasodilatory properties which can predispose or worsen varicose veins
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what are risk factors for varicose veins
family history of varicose veins older age (especially 40 years and above) pregnancy female sex history of DVT obesity prolonged standing or sitting previous lower limb fracture being caucasian
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what are symptoms of varicose veins
pain - dull ache or burning leg fatigue, discomfort, worsening pain after prolonged standing leg cramps restless legs skin discolouration over the affected areas heaviness of the legs itching after prolonged standing ankle oedema lipodermatosclerosis
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what are severe presentations of varicose veins
ulceration haemorrhage especially if the variceal segments are large, traumatised or over bony prominences thrombophlebitis
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how are varicose veins diagnosed
clinical features - presence of tortuous veins and history of risk factors duplex ultrasound can confirm the diagnosis as well as ruling out DVT ABPI can exclude peripheral artery disease
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how are varicose veins managed
referral to vascular services lifestyle changes - exercise and wt loss conservative - compression stockings using bandages or stockings however its NOT recommended by NICE unless surgical intervention is declined or inappropriate surgery - endovenous techniques or open surgery
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what endovenous techniques are used to treat varicose veins
aim to block faulty veins which has the same benefit as removing them - endothermal ablation (first line) - ultrasound guided foam sclerotherapy - glue, steam or mechanochemical devices
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what open surgery is done to treat varicose veins
ligation and stripping: incompetent veins are ties off and removed phlebectomy: varicose veins are pulled out through small incisions
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what are the viruses that cause viral gastroenteritis
rotavirus norovirus adenovirus - tends to cause resp symptoms
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what is the primary concern with gastroenteritis
dehydration
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what can be used to prevent dehydration in people with gastroenteritis
oral rehydration salt solution (dioralyte mixed with water) that helps to replace losses. It contains glucose, potassium and sodium
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what are post gastroenteritis complications
Lactose intolerance Irritable bowel syndrome Reactive arthritis Guillain–Barré syndrome Haemolytic uraemic syndrome
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what are the symptoms of the stomach flu
diarrhoea nausea and vomiting loss of appetite abdominal pain and cramping systemic symptoms: fever, chills, fatigue, body aches, headaches, lymphoedema
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what are the stages of stomach flu
1. exposure 2. incubation - few hours to a few days 3. acute infection - from a day to weeks 4. recovery
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how long is viral gastroenteritis contagious for
most contagious during the acute phase of the infection and for a few days after
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what are causes of viral gastroenteritis
norovirus - leading in adults rotavirus - leading in children astrovirus - children younger than 3 adenovirus - affects all ages
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what is exanthem
it is a widespread rash that usually is accompanied by systemic symptoms such as fever, malaise and headache
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what causes exanthems
usually due to viral infections: varicella, measles, rubella, herpes 6B and parvovirus B19 (there are many other causes such as HIV, smallpox, hepatitis, EBV etc) bacterial infection: staphylococcal and streptococcal toxin infections may also be due to medications and connective tissue disease (SLE, SJA etc)
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what are the symptoms/signs of exanthemas
non specific exanthemas appear as spots or blotches and can be itchy. The rash is widespread and may be more extensive on the trunk or extremities general symptoms: fever, malaise, headache, LOA, abdominal pain, irritability, muscle aches and pains
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how are exanthemas diagnosed
pattern of rashes and prodromal symptoms allowing for a clinical diagnosis viral swab - culture and PCR bloods - serology, PCR, ANA, tissue antibodies genotyping
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what is the treatment for exanthemas
paracetamol/simple analgesia to reduce fever moisturising emollients to reduce itch
277
what are viruses that commonly cause exanthem rash
Chickenpox (varicella-zoster virus). COVID-19 (coronavirus). Fifth disease (parvovirus B19). Hand, foot and mouth disease(coxsackievirus A16). Measles (morbillivirus). Roseola (human herpesvirus 6). Rubella (rubella virus). Other viruses that may cause viral exanthem rash include: Hepatitis, HIV, EBV
278
what are radiculopathies
radiculopathies refer to the compression of irritation of a spinal nerve route causing pain with sensory changes (numbness, pins and needles etc) or motor changes (weakness, diminished deep tendon reflexes)
279
what is the most common kind of radiculopathy
lumbar radiculopathy - tends to affect men and women in the 4th-6th decades of life
280
what is the most common cause of lumbar radiculopathies
herniated disk degenerative changes = 2nd
281
what nerve roots are the most commonly affected in lumbar radiculopathies
L4-S1
282
what are the two sections of a spinal nerve root
ventral (anterior) - motor dorsal (posterior) - sensory
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what are causes of lumbar radiculopathy
herniated disc - most common cause spinal stenosis and spondylolisthesis pelvic or lumbar fractures nerve root may become compromised due to peripheral nervus system syndromes (GBS) - polyradiculopathy cancer infection
284
what are modifiable risk factors for lumbar radiculopathy
smoking obesity strenuous physical activity whole body vibration
285
what are non modifiable risk factors for lumbar radiculopathy
age history of lower back pain genetic factors such as variations in intragenic vitamin D receptor gene
286
what are clinical features of lumbar radiculopathies
most common symptom in radiating pain (sharp, stabbing, shooting, throbbing etc) that spreads distally from the lumbar spine pain is often unilateral but can be bilateral sensory change: numbness, paraesthesia motor change: weakness, loss of strength or power pain is worse after periods of inactivity can worsen with coughing or sneezing can be acute or insidiously can be consistent, worsening or relapsing remitting
287
what medications can cause neuropathy with similar symptoms to radiculopathy
amiodarone docetaxel carbamazepine
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what might be seen on clinical examination of someone with lumbar radiculopathy
muscle atrophy diminished deep tendon reflexes gain disturbances
289
what are the targeted clinical examinations for suspected lumbar radiculopathy
dermatomes: L1-S2 myotomes: L1-S2 using the MRC scale reflexes: L3-S1 special tests: slump test and straight leg test
290
what investigations should be done for lumbar radiculopathies
majority of cases managed conservatively and dont need investigations Imaging: MRI (gold for herniation, prolapse or degenerative process), X-Ray EMG and nerve conduction tests
291
what is conservative management for lumbar radiculopathies
normally 1st line treatment 1. patient education: avoid triggers, information and reassurance 2. lifestyle modification 3. Paracetamol and NSAIDs. If pain persists use of steroid injections or oral steroids can be used. 4. referral to musculoskeletal physiotherapy 5. referral to psychological services if needed
292
what is the surgical management of lumbar radiculopathies
given if conservative management ails, symptoms are worsening, if there is a serious pathology, or severe neurological deficits - discectomy - spinal decompression - open laminectomy with discectomy - microendoscopic discectomy
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what are complications of lumbar radiculopathies
pain: functional mobility loss, loss of independence, inability to fulfil social or occupational roles Central sensitisation of nociplastic pain muscle atrophy and deconditioning progressive muscle weakness cauda equina syndrome
294
what are red flag symptoms of radiculopathy
cauda equina - faecal incontinence, urinary retention, saddle anaesthesia infection - immunosuppression, IV drug use, unexplained fever fracture - significant trauma, osteoporosis, chronic steroid use malignancy - new onset after 50 metastatic disease - history of malignancy
295
what is normally the first line prescribed treatment for radiculopathy pain
neuropathic pain medications - amitriptyline, or pregabalin and gabapentin as alternatives patients who supper from muscle spasms may be managed with benzodiazepines or baclofen
296
what are symptoms of cervical radiculopathy
pain in the neck, shoulder, upper back or arms
297
what are causes of cervical radiculopathy
disc degeneration spondylosis - age related arthritis of the vertebra bone disease cancer herniated disc
298
what is the most common site for cervical radiculopathy
lower cervical certebrae - C5-7
299
what is a common test for cervical radiculopathy
the spurling's maneuver where the individual tilts their head to the side, backwards and tries to pull their head back upright while the clinician pushes it down
300
how is varicella zoster virus transmitted
droplet spread or direct skin contact with vesicle fluid
301
what is the incubation period of varicella zoster virus
typically 10-14 days but can be up to 21 days
302
what is the prodrome symptoms of varicella zoster virus
symptoms can last up to 4 days and include: high fever general malaise myalgia anorexia headache nausea
303
what is the rash associated with varicella zoster virus
it begins as small erythematous macules on the scalp, face, trunk and proximal limbs these macules develop into papules, vesicles and pustules shallow oral and genital ulcers can occur which are painful crusting of the vesicles and pustules usually occurs within 5 days at which point new vesicle formation has ceased
304
what is the general advice given to those with chickenpox
adequate hydration avoidance of scratching avoidance of pregnant women, neonates and immunocompromised individuals
305
what is symptomatic management of chickenpox
paracetamol for fever and discomfort NSAIDS should be AVOIDED! sedating antihistamines (chlorphenamine), emollients and calamine lotion for the itch if an adolescent or adult presents within 24 hours of rash onset, oral aciclovir may be considered
306
how are high risk groups treated for chickenpox
urgent specialist advice: antiviral medication with aciclovir intravenous immunoglobulin
307
where in the UK is chickenpox a notifiable disease
scotland and northern ireland
308
how long should children with VZV stay off school
until all the lesions have crusted over
309
what are complications of chickenpox
dehydration secondary bacterial infection of the lesions scarring viral pneumonia encephalitis reyes syndrome - thought to be connected to aspirin use shingles
310
what can happen if chicken pox is caught in pregnancy
can lead to congenital varicella syndrome if contracted before 20 weeks: intrauterine growth restriction microcephaly limb hypoplasia ophthalmological defects cutaneous scarring
311
what are screening tests
check done on a healthy person to pick up a condition before it develops or at a very early stage
312
what criteria must apply before a national screening programme is considered
1. there must be a test available which picks up a disease or condition before symptoms develop 2. the test must be reasonably accurate. It should not be positive for too many people who do NOT have the condition and must not miss many people who DO have the condition 3. the test must be reasonable simple to perform and acceptable to the people having the test 4. the benefits of screening but be greater than any potential risk or harm it could cause 5. the cost of the test, must not be more than the benefits it gives 6. there must be a treatment at the early stage of the condition or disease which will make a difference to the outcome 7. the condition being screened for must be important to health and wellbeing 8. there must be an organised, efficient plan for what happens next if the test is positive
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what are the benefits of screening tests
1. in picking up problems early you can treat things earlier and increase survival 2. cancers picked up early, treatments are more likely to be successful 3. newborn baby screening allows things to be corrected if picked up early enough 4. screening in pregnancy helps to identify any serious abnormalities
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what are issues with screening tests
1. no test can be 100% accurate 2. some people may have treatment which wasnt needed due to a false positive 3. tests can cause worry - if initially test is positive but further tests are normal 4. cost: screening large numbers of healthy people is expensive 5. for some conditions screened for, a negative result at one point in time doesnt rule out developing the condition in the future 6. screening tests can lead to difficult decisions
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what are the current screening tests available in England
1. abdominal aortic aneurysm screening programme 2. bowel cancer screening 3. breast screening programme 4. cervical screening programme 5. diabetic eye screening programme 6. fetal anomaly screening programme 7. infectious diseases in pregnancy screening programme 8. newborn and infant physical examination screening programme 9. newborn blood spot screening programme 10. newborn hearing screening programme 11. sickle cell and thalassaemia screening programme
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what screening is offered in pregnancy
screening for infectious diseases (Hepatitis B, HIV and syphilis) screening for down's syndrome, pataus syndrome and edwards syndrome screening for sickle cell and thalassaemia 20 weeks screening scan diabetic eye screening
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what screening is offered to newborn babies
physical examination - eyes, heart, hips and testicles hearing screening a blood spot test
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what ages does cervical screening go between
25 to 64 it is offered every 3 years for those aged 25-49 it is offered ever 5 years for those aged 50-64
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when is diabetic eye screening offered
from the age of 12, all people with diabetes are offered regular diabetic eye screening
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when is breast cancer screening offered
to women between the ages of 50-70
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when is bowel cancer screening offered
it is offered to everyone aged 50-74 every 2 years if you are over 75 you can ask for a kit every 2 years by phoning
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when is the AAA screening offered
it is offered to men when the turn 65 to detect AAA, men over 65 fan self refer
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what is lichen planus
it is a non infectious itchy rash that affects many areas of the body: arms, legs, trunk, mouth, nails, scalp, vulva, vagina, penis
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what are the main symptoms of lichen planus
clusters of shiny raised, purple blotches on your arms, legs or body white patches on gums, tongue, or the insides of the cheeks burning and stinging in the mouth bald patches on the scalp sore red patches on vulva rough thinning nails with grooves on ring shaped purple or white patches on the penis
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what is the treatment for lichen planus
gets better on its own in about 9-18 months steroid creams or ointments - topical corticosteroids antihistamines light treatments - UVB and PUVA acitretin - specialist prescribed and used in severe cases
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what is self help advice for lichen planus
avoid washing with soap or bubble bath wash hair over basin to stop shampoo on the skin use emollients to moisturise the skin if its in the mouth - avoid spicy food, avoid alcohol, stick to soft plain foods, avoid mouthwash if on genitals - avoid bubble bath, use emollients, apply ice packs, avoid tights
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what is lichen simplex
it is a response to the skin being repeatedly scratched or rubbed over a long period of time, causing single/multiple plaques of rough skin to form, sometimes with little bumps round the hair follicles
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what causes lichen simplex
skin conditions, itchy infections, and persistent scratching - eczema, allergic dermatitis, insect bites, fungal skin infections, varicose veins and psoriasis - damage to nerves such as in shingles can also lead to lichen simplex
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what are the symptoms of lichen simplex
can be sore but is more often very itchy intense itch in bursts and may be worse at times of rest or at night itch prompts rubbing with then aggravates the skin and may lead to superficial skin infections
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what does lichen simplex look like
increased surface skin markings called lichenification - can appear as a bumpy skin rash skin may feel dry, thickened and rough to the touch affected skin often looks scaly or red over time skin becomes darker than surrounding skin
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how is lichen simplex diagnosed
history and examination skin scrapings may be taken patch testing for allergy punch biopsy
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how can lichen simplex be treated
need to break the scratch itch cycle - avoid soap, shower gel, bubble baths - cover affected skin with dressings - steroid ointments or cream - tacrolimus and pimecrolimus (topical calcineurin inhibitors) may reduce itch - coal tar creams or ointments - if the skin is broken may need antibiotics - treatment of itch: cooling creams, antihistamines, capsaicin cream, TENS
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what is scabies
it is an intensely itchy skin infection caused by sarcoptes scaniei which is a mite that burrows into the epidermis and tunnels through the stratum corneum - life cycle lasts about 4-6 weeks
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what are the two kinds of scabies
classical - infestation with a low number of mites crusted - hyperinfestation with thousands or millions of mites present in exfoliating scales of skin. due to insufficient immune response by the host
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how is scabies transmitted
close/prolonged skin contact with an infested person - can be sexually acquired - transmission through casual contact is unlikely - symptoms begin 3-6 weeks after primary infestation Crusted scabies is highly contagious and can be transmitted via bedding, towels, clothes etc
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what are risk factors for getting scabies
close contact with infected person high levels of poverty and social deprivation crowded living conditions winder months crusted - immunosuppression, elderly, learning difficulties or neurological disorders
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what are complications of scabies
secondary bacterial infection secondary eczematization nodular scabies
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how is scabies diagnosed
history - itch worse at night, symptoms beginning 3-6 weeks after primary infestation examination - erythematous papules on the periumbilical area, waist, genitalia, breasts, buttocks, axillary folds, fingers, wrists and extensor aspects of the limbs. nodular lesions ink burrow test microscopy and skin scrapings
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what is a pathognomonic sign for scabies
the burrow sign - thin brown grey line of 0.2-1cm in length - these are produced by moving mite
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how is scabies managed
seek specialist advice if child is under 2 months in crusted scabies hospital admission may be needed, and may need topical insecticide and oral ivermectin for normal: prescribe permethrin 5% cream, advice all members of household and close sexual partners also be treated. Refer to GUM clinic treat post scabietic itch with crotamiton 10% cream or with topical hydrocortisone 1% if scabies have 100% been eradicated
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what are symptoms of scabies
Symptoms of scabies usually begin 4–6 weeks after infestation. Sometimes there are visible signs before symptoms begin. Symptoms of scabies include: severe itch, often worse at night; itchy lines (linear burrows) and bumps (papules) on the fingers, wrists, arms, legs and belt area; enflamed bumps on male genitalia and female breasts; and larger rash in infants and small children, including on the palms, soles of the feet, ankles and scalp.
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