Paediatrics - orthopaedics, rheumatology and dermatology Flashcards

1
Q

what is osteogenesis imperfecta

A

Osteogenesis imperfecta is a genetic condition that results in brittle bones that are prone to fractures. It is caused by a range of genetic mutations that affect the formation of collagen (type 1)

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2
Q

what are the features of osteogenesis imperfecta

A

Hypermobility
Blue / grey sclera (the “whites” of the eyes)
Triangular face
Short stature
Deafness from early adulthood
Dental problems, particularly with formation of teeth
Bone deformities, such as bowed legs and scoliosis
Joint and bone pain

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3
Q

what other conditions is osteogenesis imperfecta associated with

A

congenital cataracts

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4
Q

what are the four major clinical features which characterises osteogenesis imperfecta

A
  1. osteoporosis with abnormal bone fragility
  2. blue sclera
  3. dentinogenetic imperfecta
  4. hearing impairment
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5
Q

what is the pathophysiology of osteogenesis imperfecta

A

there is a disturbance in the synthesis of type 1 collagen, which is the predominant protein of the extracellular matrix of most tissue
in bone this defect results on osteoporosis which increases the tendency to fracture
type 1 collagen is also a major constituent of dentine, sclarae, ligaments, blood vessels and skin

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6
Q

what are the genetic abnormalities behind osteogenesis imperfecta

A

mutation in one of two genes that carry instructions for making type 1 collagen
mutations in the COL1A1 and COL1A2 genes are responsible for over 90% of cases

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7
Q

what are the three main types of osteogenesis imperfecta

A
  1. mild: type 1
  2. perinatal lethal: type 2
  3. progressive deforming: type 3
    types 4 and 5 are variable in severity and are uncommon
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8
Q

what features of osteogenesis imperfecta may be seen on antenatal scans

A

decreased attenuation and abnormally increased visualisation of fetal brain
may show evidence of fractures
may be evidence of polyhydramnios

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9
Q

what is the treatment of osteogenesis imperfecta

A

Bisphosphonates
vitamin D supplementation
physiotherapy and occupational therapy
paediatricians for follow up
orthopaedic surgeons for managing fractures
specialist workers
social workers

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10
Q

what is rickets

A

rickets is a condition affecting children where there is defective bone mineralisation causing soft and deformed bones

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11
Q

what are causes of rickets

A

rickets is caused by a deficiency in vitamin D or calcium
rare form of rickets is caused by genetic defects that results in low blood phosphate

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12
Q

how is vitamin D obtained in the body

A

produces in response to sunlight
obtained through eating foods such as eggs, oily fish or fortified cereals or supplements

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13
Q

what is hereditary hypophosphataemic rickets

A

this is a rare form of rickets caused by an X linked dominant disorder, where there is low phosphate in the blood

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14
Q

what is the pathophysiology of rickets

A
  1. vitamin D is a hormone created by cholesterol in response to UV
  2. reduced sun without vitamin D supplementation leads to a deficiency
  3. malabsorption disorders can also cause vitamin D deficiency, and so can chronic kidney disease
  4. Vitamin D is essential for calcium and phosphate absorption as well as regulating bone turnover and promoting bone resorption to boost serum calcium
  5. inadequate vitamin D leads to a lack of calcium and phosphate in the blood, leading to defective bone mineralisation.
  6. low calcium also causes a secondary hyperparathyroidism
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15
Q

how does rickets present

A

lethargy
bone pain
swollen wrists
bone deformities
poor growth
dental problems
muscle weakness
pathological or abnormal fractures

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16
Q

what bone deformities can occur in rickets

A

Bowing of the legs - legs curve outward
knock knees - curve inwards
rachitic rosary - where the ends of the ribs expand and the costochondral junctions causing lumps along the chest
craniotabes - soft skull with delayed closure of the sutures and frontal bossing
delayed teeth - under-developed enamel

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17
Q

what investigations should be done in someone with suspected rickets

A

Serum 25-hydroxyvitamin D
W ray
serum calcium and phosphate
serum alkaline phosphatase
parathyroid hormone levels
FBC and ferritin
inflammatory markers
kidney function tests
liver function tests
thyroid function tests
malabsorption screen
autoimmune and rheumatoid tests

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18
Q

what level of serum 25-hydroxyvitamin D in the blood would establish a diagnosis of vitamin D deficiency

A

25 nmol/L or less

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19
Q

what is the management for children with rickets

A

children with vitamin D deficiency can be treated with vitamin D (ergocalciferol) with doses depending on the age
- dose for children between 6 months and 12 years is 6,000 IU per day for 8-12 weeks
children with features of rickets should be referred and treated with vitamin D and calcium. can also have surgery

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20
Q

how can you prevent rickets from occurring

A

breastfed babies are at higher risk of vitamin D deficiency than formula fed babies
breastfeeding women and all children should take vitamin D supplementation
NICE recommends 400 IU (10mg) supplement per day

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21
Q

what is transient synovitis

A

a temporary irritation and inflammation in the synovial membrane of a joint

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22
Q

what is transient synovitis often associated with

A

a recent viral upper respiratory tract infection

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23
Q

how does transient synovitis present

A

occurs within a few weeks of viral illness
hip presents in flexion, abduction and external rotation
limp
refusal to weight bear
groin or hip pain
limited range of movement: most commonly hip abduction
mild low grade fever
normal obs and should be systemically well

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24
Q

how is transient synovitis diagnosed

A

need to rule out septic arthritis
- bed side observations
- bloods: full screen + culture
- imaging: X-ray, USS

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25
what is the management of transient synovitis
normally a self limiting disorder and so management is symptomatic with simple analgesia to help the discomfort - children 3-9 may be managed in primary care if the limp is present for less than 48hrs and they are otherwise well - SAFTEY NET - follow up at 48hrs and 1 weeks to ensure symptoms are improving and resolve
26
what percentage of patients may have recurrence of transient synovitis
20%
27
what is septic arteritis
this is infection within a joint
28
what age does septic arthritis most commonly happen in
in children under the age of 4
29
how does septic arthritis present
affects one joint - knee or hip mc rapid onset of: hot, red, swollen and painful joint refusing to weight bear stiffness and reduction in the range of movement systemic symptoms such as fever, lethargy and sepsis
30
what are the causative organisms of septic arthritis
staphylococcus aureus is most common neisseria gonorrhoea group A strep (pyogenes) haemophilus influenza e. coli
31
what are differential diagnosis for septic arthritis
transient synovitis perthes disease slipped upper femoral epiphysis juvenile idiopathic arthritis
32
how is septic arthritis diagnosed
Bloods: full screen + cultures imaging: X-ray, ultrasound joint aspiration and culture
33
how is septic arthritis treated
Empirical antibiotics IV given until sensitivities are known, choice of which depends on local guidelines (normally ceftriaxone and vancomycin) antibiotics are given for 30-6 weeks patients may require surgical drainage and washout to clear the joint of infection
34
what is osteomyelitis
it is an infection in the bone and bone marrow which typically occurs in the metaphysis of the long bones
35
how might infection be introduced to the bone in osteomyelitis
directly - open fracture travelled through the blood after entering through another route such as skin or gums
36
what are risk factors for developing oseomyelitis
more common in boys more common in children under 10 open bone fracture orthopaedic surgery immunocompromised sickle cell anaemia HIV tuberculosis
37
how does osteomyelitis present
acutely with an unwell child/chronically with subtly features refusing to use the limb or weight bear pain swelling tenderness may be afebrile or have a low grade fever
38
what investigations should be done for osteomyelitis
X ray is first line imaging, MRI is the best bloods: inflammatory markers and wbc blood culture bone marrow aspiration/biopsy with histology and culture
39
how is osteomyelitis managed
extensive and prolonged antibiotic therapy - flucloxacillin, clindamycin if penicillin allergy, vancomycin if staph. aureus suspected surgical drainage and debridement of infected bone
40
what is Perthes disease
involves the disruption of blood flow to the femoral head causing avascular necrosis of the bone, affecting the epiphysis of the femur
41
what is the most common ages Perthes disease affects
children aged 4-12 mostly between the ages of 5-8 and most commonly in boys
42
what are the causes of Perthes disease
idiopathic - theory suggests that repeated mechanical stress to the epiphysis may interrupt the blood supply
43
what is the presentation of Perthes disease
slow onset of: pain in the hip or groin limp restricted hip movements and stiffness with loss of internal rotation and abduction may be referred pain to the knee muscle spasms leg length discrepancy (late finding)
44
what investigations are done for Perthes disease
initial investigation - X ray bloods: inflammatory markers technetium bone scan MRI scan
45
what is the main complication of Perthes disease
soft and deformed femoral head which leads to early hip osteoarthritis
46
how may patients with Perthes disease will need a total hip replacement
around 5% of patients
47
what is the management of Perthes disease
initial management in younger and less severe disease is conservative help maintain a healthy position and alignment in the joint and reduce the risk of damage or deformity to the femoral head with: bed rest, traction, crutches, analgesia physiotherapy regular X rays surgery to help with alignment and function
48
what are the radiographic findings in Perthes disease
asymmetrical femoral epiphyseal size increased density of femoral head epiphysis radiolucency coxa plana: femoral head widening and flattening coxa magna: proximal femoral neck deformity sagging rope sign: thin sclerotic line running across the femoral neck crescent sign is a specific finding in late stage disease and represents a subchondral fracture
49
what might increase the likelihood for surgery in perthes disease
age over 8 years old more than 50% of the femoral head is damaged nonsurgical management has been unsuccessful
50
what are the complications of Perthes disease
osteoarthritis general join stiffness and immobility premature physeal arrest, degenerative arthritis acetabular dysplasia unequal, shortened limb length
51
what is discoid menisci
A discoid meniscus is thicker than normal, and often oval or disc-shaped. It is more prone to injury than a normally shaped meniscus.
52
what is the clinical presentation of discoid menisci
frequently asymptomatic but discoid menisci are prone to cystic degeneration with subsequent tearing if this happens it presents as: pain, locking or a clunk sensations stiffness or swelling pain feeling as if the knee is giving way inability to fully extend the knee
53
what is the pathophysiology of discoid menisci
there is decreased collagen fibres and loss of normal collagen orientation which predisposes them to intradiscal/meniscal mucoid degeneration
54
what are the different classifications of discoid menisci
complete vs incomplete stable vs unstable
55
what is the difference between complete and incomplete discoid menisci
80% coverage of the tibial plateau is often used as the cut off between incomplete and complete
56
what is the difference between stable and unstable discoid menisci
stable: normal peripheral attachments with an intact posterior meniscofemoral ligament unstable: lack or tear of a posterior meniscocapsular ligaments with an attachment only from the meniscofemoral ligament of Wrisberg
57
what are radiographic features of discoid menisci
plain radiograph: widening of the lateral joint space and cupping of the lateral tibial plateau MRI: meniscal body width of 15mm or more is typically considered diagnostic (coronal)
58
what is the treatment of discoid menisci
conservative management may need meniscal repair with partial or total resection
59
what are complications of discoid menisci
meniscal tears intrasubstance mucoid degeneration early bony degenerative change
60
what is the meniscus
it acts as a shock absorber between the femur and the tibia. it protects the thin articular cartilage that covers the ends of the bones and helps the knee to easily bend and straighten
61
what is incomplete discoid meniscus
the meniscus is slightly thicker and wider than normal
62
what is complete discoid meniscus
when the meniscus completely covers the tibia
63
what is hypermobile Wrisberg discoid meniscus
this occurs when the ligaments that attach the meniscus to the femur and tibia are not there. Without these ligaments even a fairly normal shaped meniscus can move around the joint and cause pain, as well as licking and popping of the knee
64
why is the discoid meniscus more proneto injury
due to the thick, abnormal shape f a discoid meniscus makes it more likely to get stuck in the knee or to tear
65
why is meniscus difficult to heal
because the meniscus lacks a strong blood supple and the nutrients that are essential to healing cant reach the injured tissue
66
what is the cause of discoid meniscus
it is a congenital defect that is present from birth
67
what is the surgical treatment for discoid meniscus
knee arthroscopy is the most common - few small incisions and meniscus is cut and reshaped
68
what is slipped upper femoral epiphysis
it is where the head of the femur is displaced (slips) along the growth plate
69
when is slipped upper femoral epiphysis most common
it is most common around the ages of 8-15 most common in boys around 12 rarer in girls, and presents around 11 it is more common in obese children
70
how does Slipped Upper Femoral Epiphysis present
typical presentation is an adolescent , obese male undergoing a growth spurt. There may be history of minor trauma pain is disproportionate to the severity of the trauma hip, groin, thigh or knee pain restricted range of movement in the hip painful limp
71
what will examination show for Slipped Upper Femoral Epiphysis
the patient will prefer to keep the hip in external rotation they will have limited movement of the hip, particularly restricted internal rotation
72
how do you diagnose Slipped Upper Femoral Epiphysis
initial investigation is Xray bloods: normal technetium bone scan Ct and MRI
73
how is Slipped Upper Femoral Epiphysis managed
surgery is required to return the femoral head to the correct position and fix it in place to prevent it slipping further
74
what is Osgood-Schlatter disease
inflammation at the tibial tuberosity where the patella ligament inserts and is common cause of anterior knee pain in adolescents
75
when does Osgood-Schlatter disease typically present
at around 10-15 years more common in males
76
what is the pathophysiology of Osgood-Schlatter disease
the patella tendon inserts into the tibial tuberosity which is at the epiphyseal plate. stress from running, jumping and other movements at the same time as growth can result in inflammation on the tibial epiphysial plate. there are multiple small avulsion fractures where the patella ligament pulls away pieces if the bone. this leads to growth of the tibial tuberosity causing a visible lump below the knee initially this is tender due to inflammation but as the bone heals it becomes hard and non tender
77
how does Osgood-Schlatter disease present
gradual onset of symptoms visible or palpable hard and tender lump at the tibial tuberosity pain in the anterior aspect of the knee pain exacerbated by physical activity, kneeling and on knee extension
78
how is Osgood-Schlatter disease managed
reducing pain and inflammation - reduction of physical activity - ice - NSAIDs for symptomatic relief once symptoms settle, stretching and physiotherapy can be used to strengthen the joint and improve function
79
what is the prognosis of Osgood-Schlatter disease
symptoms should fully resolve over time patient is usually left with a hard bony lump on their knee
80
what is a rare complication of Osgood-Schlatter disease
full avulsion fracture where the tibial tuberosity is separated from the rest of the tibia
81
how do you treat a full avulsion fracture
this usually requires a surgical intervention
82
what is developmental dysplasia of the hip
it is a disorder of abnormal development resulting in dysplasia and potential subluxation or dislocation of the hip secondary to capsular laxity and mechanical factors
83
when does developmental dysplasia of the hip occur
most common abnormality in newborn infants.
84
which hip is most commonly affected in developmental dysplasia of the hip
due to the nature of how the baby sits in the womb the left hip is more commonly affected
85
what are risk factors of developmental dysplasia of the hip
family history of DDH breeched baby female sex fixed root deformity torticollis
86
what are clinical features of developmental dysplasia of the hip
leg length discrepancy limitations in hip abduction on one side significant bilateral restriction in abduction in children older than 1 a Trendelenburg gait and toe walking may also be seen asymmetrical buttock creases hip locking/clicking pain
87
what tests are used to screen babies for hip dysplasia
Ortolani and Barlow tests
88
what is the Barlow test
performed by adducting the hip (bringing the thigh towards the midline) whilst applying light pressure on the knee with your thumb, directing the force posteriorly. If the hip is unstable, the femoral head will slip over the posterior rim of the acetabulum, producing a palpable sensation of subluxation or dislocation. If the hip is dislocatable the test is considered positive.
89
what is the Ortolani test
Ortolani test is done with the baby on their back with the hips and knees flexed. Palms are placed on the baby’s knees with thumbs on the inner thigh and four fingers on the outer thigh. Gentle pressure is used to abduct the hips and apply pressure behind the legs with the fingers to see if the hips will dislocate anteriorly.
90
how is Developmental dysplasia of the hip diagnosed
when it is suspected an ultrasound of the hips will be investigation of choice and establish the diagnosis all children with risk factors or examination findings should have an ultrasound Xray can also be used in older infants (greater than 4-6 months)
91
what is the management of Developmental dysplasia of the hip
under 6 months: Pavlik harness 6-8 months or failure of Pavlik harness: closed reduction and spica casting greater than 18 months (or failure of closed reduction): operative management (open reduction and hip reconstruction)
92
what is a Pavlik harness
it is used in Developmental dysplasia of the hip when the baby is under 6 months. it is fitted and kept on permanently and adjusted for growth. it holds the femoral head in the correct position to allow the acetabulum to develop a normal shape. The harness keeps the babies hips flexed and abducted
93
what are complications of Developmental dysplasia of the hip
recurrence transient femoral nerve palsy with excessive flexion during Pavlik bracing avascular necrosis due to retrograde femoral head blood flow (mc affected is the median circumflex femoral artery)
94
what is juvenile idiopathic arthritis
it is a condition affecting children and adolescents where autoimmune inflammation occurs in the joints
95
when is JIA diagnosed
when the arthritis is without any other cause when it lasts more than 6 weeks when it is in a patient under 16
96
what are the different subtypes of JIA
five key ones: systemic JIA polyarticular JIA oligoarticular JIA enthesitis related arthritis juvenile psoriatic arthritis
97
what is systemic JIA
this is a systemic illness that can occur throughout childhood it is an idiopathic inflammatory condition
98
what are the typical features of systemic JIA
subtle salmon pink rash high swinging fevers enlarged lymph nodes weight loss joint inflammation and pain splenomegaly muscle pain pleuritis and pericarditis
99
will antinuclear antibodies and rheumatoid factor be positive or negative in systemic JIA
usually negative however there will be raised inflammatory markers with raised CRP, ESR, platelets and ferritin
100
what is a key complication of systemic JIA
macrophage activation syndrome
101
what is macrophage activation syndrome
it is where there is a severe activation of the immune system with a massive inflammatory response
102
how does macrophage activation syndrome present
It presents with an acutely unwell child with disseminated intravascular coagulation (DIC), anaemia, thrombocytopenia, bleeding and a non-blanching rash. It is life threatening
103
what is a key investigation finding in macrophage activation syndrome
low ESR
104
what is polyarticular JIA
it involves idiopathic inflammatory arthritis in 5 joints or more
105
what are the features of polyarticular JIA
it tends to be symmetrical can affect small joints of the hands and feet as well as larger ones minimal systemic symptoms but there can be mild fever, anaemia and reduced growth
106
what disease is polyarticular JIA the same as in adults
rheumatoid arthritis
107
are children with polyarticular JIA rheumatoid factor positive or negative
most are negative - seronegative if rheumatoid factor is positive they tend to be older children and adolescents and the disease pattern is much more similar to rheumatoid arthritis in adults
108
what is oligoarticular JIA
it involves 4 joints or less, usually affecting only a single joint
109
which joints does oligoarticular JIA commonly affect
the larger joints - often the knee or ankle
110
who does oligoarticular JIA most commonly occur in
in girls under the age of 6
111
what is a classic feature that is associated with oligoarticular JIA
anterior uveitis
112
what are the features of oligoarticular JIA
4 or less joints affected associated with anterior uveitis patients tend to have no systemic symptoms antinuclear antibodies are often positive, rheumatoid factor is usually negative
113
what is enthesitis related arthritis
this is thought of as a paediatric version of seronegative spondyloarthropathy it is inflammation of the point where a tendon of a muscle inserts into a bone. Patients have inflammatory arthritis in the joints as well as enthesitis
114
what can enthesitis be caused by
traumatic stress such as repetitive strain during sport autoimmune inflammatory process
115
what can help to diagnose enthesitis
an MRI scan (cant differentiate between what it is due to)
116
what gene do the majority of patients with enthesitis related arthritis have
HLA - b27
117
when assessing a patient with enthesitis related arthritis what else should you be considering
signs and symptoms of psoriasis signs and symptoms of IBD signs and symptoms of anterior uveitis
118
what are features of enthesitis related arthritis
patients will have tenderness to localised palpation of the entheses may have signs of psoriasis, IBD or anterior uveitis
119
what key areas are worth palpating in patients with enthesitis related arthritis
interphalangeal joints in the hand wrist over the greater trochanter on the lateral aspect of the hip quadriceps insertion at the anterior superior iliac spine quadriceps and patella tendon insertion around the patella base of achilles at the calcaneus metatarsal heads on the base of the foot
120
what is juvenile psoriatic arthritis
this is a seronegative inflammatory arthritis when associated with psoriasis
121
what are signs associated with juvenile psoriatic arthritis
plaques of psoriasis on the skin pitting of the nails onycholysis - separation of the nail from nail bed dactylitis - inflammation of full finger enthesitis - inflammation of the entheses
122
how is juvenile idiopathic arthritis managed
MDT approach NSAIDs such as ibuprofen steroids either oral, IM or intra articular in oligoarthritis DMARDs such as methotrexate, sulfasalazine and leflunomide biologic therapy such as TNF inhibitors etanercept, infliximab and adalimumab
123
what is scoliosis
it is an abnormal side to side curve of your spine - can range from mild to severe
124
what are the different names for idiopathic scoliosis dependent on when it is diagnosed
infantile - younger than 3 juvenile - age 4-10 adolescent - 11-18 adult - any time after 18
124
what are the three types of scoliosis
idiopathic - most common congenital - when vertebrae dont form as they should during development neuromuscular - abnormalities in the muscles and nerves that support the spine causes this, usually occurs alongside neurological or muscular conditions like injury, cerebral palsy, spina bifida or muscular dystrophy
125
how common is scoliosis
affects an estimated 2% of people around the world
126
what are symptoms of scoliosis
back pain difficulty standing upright core muscle weakness leg pain, numbness or weakness
127
what are the signs of scoliosis
uneven shoulders shoulder blades that stick out head that doesnt centre around the pelvis uneven waist elevated hip constant leading to one side uneven leg length changes in skin appearance or texture (dimples, hair patches, discolouration)
128
what part of the spine does scoliosis affect
adolescents - most occur in the thoracic spine adults - mainly lumbar or the lower spine
129
what can cause scoliosis
vertebrae malformation during development genetic mutation spinal injury tumour muscle/nerve condition
130
what are risk factors for developing scoliosis
biological family history of scoliosis underlying nerve/muscle condition
131
what are complications of scoliosis
long lasting pain physical deformity organ damage nerve damage arthritis spinal fluid leakage difficulty breathing
132
how is scoliosis diagnosed
scoliosis screening - remove shirt and stand up straight and bend forward. physical examination X-rays (from front and side) CT/MRI
133
how is scoliosis measured
measure the curve of the spine in degrees no scoliosis diagnosis: less than 10 degrees Mild: between 10-24 degrees moderate: between 25-39 degrees severe: more than 40 degrees
134
how is scoliosis treated
dependent on type and severity - conservative: regular monitoring, analgesia, exercise/physio, back brace - surgery: stabilise spine and relieve pressure on nerves
135
what surgery is done to correct scoliosis
spinal fusion: fuse vertebrae to stabilise spine, and use metal braces to hold spine in place expandable rod: insertion of an expandable rod along vertebrae to support a child's growing spine
136
what is torticollis
it is when the babies neck muscles cause their head to turn and rotate to one side due to a short, tight sternocleidomastoid muscle
137
what are the two types of torticollis
congenital - mc acquired
138
when does acquired torticollis usually occur
in the first four to six months of a babies life
139
what are the symptoms of torticollis
babies head tilts to one side and the chin tilts to the other limited movement of the babies head and neck one shoulder will be higher than the other swollen neck muscles small pea sized limp in one of the babies neck muscles uneven facial features
140
what additional symptoms may be present in acquired torticollis
severe neck pain head tremors headache
141
what causes torticollis
it is due to shortening of the sternocleidomastoid muscle. It is unsure why it shortens but may be due to positioning in the womb, abnormal development, haemotoma, fibrosis or Klippel-Feil syndrome
142
what is Klippel-feil syndrome
a rare birth defect that causes the vertebrae in the neck to fuse
143
what causes acquired torticollis
because of swelling around the throat. This swelling causes the tissues surrounding the upper spine to loosen, allowing vertebrae to move out of the normal position. this causes neck muscles to spasm and causing the head to tilt to one side can also be due to GORD, vision problems, reaction to medications, scar tissue, cervical spondylarthritis, sandifer syndrome, grisel syndrome
144
what is Sandifer syndrome
rare condition which combines GORD with neck spasms
145
what is Grisels syndrome
rare complication of head and neck infections or ENT surgeries
146
how is torticollis diagnosed
physical examination neck X ray head and neck CT/MRI
147
what is the management of torticollis
stretching exercised and position changes can help congenital torticollis may need surgery to lengthen SCM muscle in acquired need to focus on the underlying cause: antibiotics, botox injections, heat therapy, massage, neck braces/collars, physical therapy
148
what are growth plates
they are found in the bones of children, but not adults. they are the area at the ends of long bones that allow the bones to grow in length
149
what are growth plates made from
hyaline cartilage
150
what is the difference between bones of children compared to adults
1. children have growth plates 2. children have more cancellous bone which is spongy and highly vascular making them more flexible but less strong
151
what are the differences in fractures in children compared to adults
1. the younger the child the faster and better the healing of fractures 2. when bones break in children they are much more likely to break clean in two 3. children are more likely to get greenstick fractures where one side of the bone breaks while the other stays intact 4. children are more likely to have a buckle fracture
152
what are types of fracture
Buckle transverse oblique spiral segmental salter-harris (growth plate fracture) comminuted greenstick
153
what are issues with fractures in the growth plate
they can cause issues with growth of the bone
154
what classification is sued to grade growth plate fractures
the Salter harris classification - the higher the grade the more likely it will affect growth
155
what are the different types of growth plate fractures
SALTR pneumonic type 1: Straight across type 2: Above type 3: BeLow type 4: Through type 5: CRush
156
what are the principles of managing a fracture in children
think safeguarding - is it a reasonable fracture? mechanical alignment via closed reduction via manipulation of the joint, or open reduction via surgery then provide stability with fixing the bone
157
what are ways a bone can be fixed in place post fracture
external casts K wires intramedullary wires intramedullary nails screws plate and screws
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how do you manage pain in a child with a fracture
WHO have a pain ladder for children with two steps 1. paracetamol or ibuprofen 2. morphine
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how may hip pain present in children
limp refusal to weight bare refusal to use affected leg inability to walk pain swollen or tender joint
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what are causes of joint pain in children 0-4 years old
septic arthritis developmental dysplasia of the hip transient arthritis
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what are causes of joint pain in children 5-10 years old
septic arthritis transient arthritis perthes disease
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what are causes of joint pain in children 10-16 years old
septic arthritis slipped upper femoral epiphysis juvenile idiopathic arthritis
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what are red flags for hip pain in children
Child under 3 years Fever Waking at night with pain Weight loss Anorexia Night sweats Fatigue Persistent pain Stiffness in the morning Swollen or red joint
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when would you urgently refer a limping child
Child under 3 years Child older than 9 with a restricted or painful hip Not able to weight bear Evidence of neurovascular compromise Severe pain or agitation Red flags for serious pathology Suspicion of abuse
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how do you manage a child with a limp/hip pain
bloods: inflammatory markers, anaemia C-rays ultrasound joint aspiration MRI
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what is Talipes
it is a fixed abnormal ankle position that presents at birth
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what is talipes equinovarus
this is when the ankle is in plantar flexion and supination
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what is talipes calcaneovalgus
this is when the ankle is in dorsiflexion and pronated
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what is the ponseti method
this is a way of treated talipes without surgery where the foot is manipulated towards a normal position and a cast is applied to hold it in position. this is repeated over and over until the foot is in the correct position at some point an achilles tenotomy is perfroed to release tension in the achilles tendon after treatment with casts, a brace is used to hold the feet in correct position when not walking until the child is around 4
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what is positional talipes
this is a common condition where the resting position of the ankle is in plantar flexion and supination, however it is not fixed and there is no structural boney issue in the ankle - muscles are slightly tight but bones unaffected - foot can be moved into a normal position - physiotherapist provide exercises to help move foot back into a normal position
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what is achondroplasia
it is the most common cause of disproportionate short stature (dwarfism) - type of skeletal dysplasia
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what is the cause of achondroplasia
the achondroplasia gene (fibroblast growth factor receptor 3) is on chromosome 4, and achondroplasia results from either a sporadic mutation or inheritance of an abnormal copy - causes abnormal function of the epiphyseal plates and restricts bone growth
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what is the inheritance pattern of achondroplasia
autosomal dominant
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what are features of achondroplasia
disproportionate short stature - average height is around 4ft short digits bow legs disproportionate skull foramen magnum stenosis
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what bones are affected in achondroplasia
limbs are more affected, with the femur and humerus being affected more than the bones in the forearm and lower leg spine is less affected and patients have a normal trunk
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how does achondroplasia affect the skull
there is disproportionate skull as different areas of the skull grow by different methods 1. skull base grows and fuses via endochondral ossification and is affected, leading to a flattened mid face, nasal bridge, and foramen magnum stenosis 2. cranial vault grows and fuses via membranous ossification and is unaffected leading to a normal sized vault and frontal bossing
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what other conditions is achondroplasia associated with
recurrent otitis media kyphoscoliosis spinal stenosis obstructive sleep apnoea obesity foramen magnum stenosis can lead to cervical cord compression and hydrocephalus
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what is the management of achondroplasia
no cure - MDT approach pediatricians specialist nurses physiotherapists occupational therapists dieticians orthopaedic surgeons - leg length durgery can add height but requires extensive surgery and recovery ENT surgeons genetics
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what surgery is done to help people with achondroplasia
leg lengthening surgery - involves cutting the bone and separating the two parts creating a gap between them. Over a long time bone will form between the two parts, creating a longer bone
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what is Ehlers danlos syndrome
group of genetic conditions involving defects in collagen, causing hypermobility in the joints and abnormalities in the connective tissue of the skin, bones, blood vessels and organs
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what are the types of ehlers-danlos syndrome
Hypermobile classical vascular kyphoscoliotic
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what are the key features hypermobile ehlers-danlos syndrome
it is the most common and least severe type joint hypermobility soft and stretchy skin inherited in an autosomal dominant pattern
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what are features of classical ehlers danlos syndrome
very stretchy skin that feels smooth and velvety severe joint hypermobility joint pain abnormal wound healing lumps often develop over pressure points prone to hernias, prolapses prone to mitral regurgitation and aortic root dilation inheritance is autosomal dominant
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what are features of vascular ehlers-danlos syndrome
most severe and dangerous blood vessels particularly fragile and prone to rupture patients have thin translucent skin gastrointestinal perforation and spontaneous pneumothorax patients monitored for vascular abnormalities autosomal dominant inheritance pattern
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what are features of Kyphoscoliotic ehlers danlos syndrome
it is characterised initially by poor muscle tone as a neonate and infant, followed by kyphoscoliosis as they grow significant hypermobility joint dislocation is common inheritance is autosomal dominant
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how does Ehlers-Danlos syndrome present
joint hypermobility and pain joint dislocations soft and stretchy skin easy bruising poor wound healing bleeding chronic pain and fatigue headaches POTS/autonomic dysfunction GORD abdominal pain and IBS menorrhagia and dysmenorrhoea premature rupture of membranes in pregnancy urinary incontinence pelvic organ prolapse temporomandibular joint dysfunction
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what is the Beighton score
assess hypermobility in children and adults one point is scored for each side of the body with a maximum score of 9
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what is the Beighton score testing in patients
1. if they can place their palms flat on the floor with their legs straight (scores only 1) 2. hyperextended elbows 3. hyperextended knees 4. ability to bend their thumb to touch their forearm 5. hyperextended their little finger past 90 degrees
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how is Ehlers-Danlos syndrome managed
no cure - manage symptoms regular follow up physiotherapy to strengthen and stabilise joints occupational therapy moderating activity
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what is Henoch-schonlein purpura
it is an IgA vasculitis that presents with a purpuric rash affecting the lower limbs and buttocks in children
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what parts of the body does Henoch-scholein purpura affect
the skin, kidneys and gastrointestinal tract
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what is Henoch-schonlein purpura most commonly triggered by
upper airway infection or gastroenteritis
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what are the classical features of Henoch-schonlein purpura
purpura joint pain abdominal pain renal involvement
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what causes the rash in Henoch-schonlein purpura
inflammation and leaking of blood from small blood vessels under the skin forming purpura
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where does the purpura typically present first in Henoch-schonlein purpura
start on the legs and spread to the buttocks they can also affect the trunk and arms
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what joints are typically affected in Henoch-schonlein purpura
arthralgia/arthritis typically affect the knees and ankles in Henoch-schonlein purpura
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what can happen to GI system in Henoch-schonlein purpura
abdominal pain gastrointestinal haemorrhage intussusception bowel infarction
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how does Henoch-schonlein purpura affect the kidneys
via IgA nephritis which can lead to microscopic or macroscopic haematuria and proteinuria
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how is Henoch-schonlein purpura diagnosed
exclude other causes of non-blanching rash FBC and blood film renal profile serum albumin CRP blood cultures urine dipstick urine protein: creatinine ratio blood pressure
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what is the diagnostic criteria for Henoch-schonlein purpura
palpable purpura + at least one of: diffuse abdominal pain arthritis or arthralgia IgA deposits on histology proteinuria or haematuria
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how is Henoch-schonlein purpura managed
supportive with simple analgesia, rest and hydration steroids is debatable monitored closely via urine dip and blood pressure
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what is the prognosis of Henoch-schonlein purpura
abdo pain usually settles within a few days patients without kidney involvement can recover within 4-6 weeks 1/3 of patients will have recurrence within 6 months
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what are the three phases of kawasaki disease
Acute phase: unwell with fever, rash and lymphadenopathy subacute: desquamation and arthralgia occur and risk of aneurysms convalescent stage: remaining symptoms settle, blood tests return to normal, aneurysms may regress (lasts 2-4 weeks)
204
what is rheumatic fever
it is an autoimmune condition triggered by streptococcus bacteria it causes antibodies created to fight streptococcus bacteria to target tissues in the body
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what is the pathophysiology of rheumatic fever
caused by group A beta haemolytic streptococcus (pyogenes) which typically causes tonsillitis antibodies created to fight this infection not only target the bacteria, but also match antigens on cells in the body resulting in a type 2 hypersensitivity reaction where the immune system attacks its own cells
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what type of hypersensitivity reaction is rheumatic fever
type 2 hypersensitivity
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when does rheumatic fever present after initial streptococcus infection
2-4 weeks after the initial infection
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how does rheumatic fever present
fever joint pain rash shortness of breath chorea nodules
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what joint involvement can you get in rheumatic fever
migratory arthritis affecting the large joints, with hot swollen painful joints. - different joints become inflamed and improve at different times
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what heart involvement can you get in rheumatic fever
carditis, inflammation throughout the heart, with pericarditis, myocarditis and endocarditis - tachycardia or bradycardia - murmurs (typically through mitral valve disease) - pericardial rub on auscultation - heart failure
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what skin involvement can you get with rheumatic fever
subcutaneous nodules - firm painless nodules over extensor surfaces of joints erythema marginatum rash - pink rings of varying sizes affecting the torso and proximal limbs
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what nervous system involvement can you get in rheumatic fever
chorea - uncontrolled irregular rapid movements of the limbs
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how is rheumatic fever diagnosed
throat swab for culture ASO antibody titres ECHO, ECG and chest Xray diagnosis is made using the jones criteria
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how do antistreptococcal antibody titres change though infection
they indicate recent infection and can support a diagnosis of rheumatic fever. they rise over 2-4 weeks after initial infection. they peak around 3-6 weeks and then gradually fall over 3-12 months
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what is the jones criteria for diagnosing rheumatic fever
evidence of recent streptococcal infection plus: two major criteria OR one major plus two minor criteria
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what are the major criteria in the Jones criteria for rheumatic fever
joint arthritis organ inflammation, such as carditis nodules erythema marginatum rash sydenham chorea
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what are the minor criteria in the jones criteria for diagnosing rheumatic fever
fever ECG changes (prolonged PR interval) without carditis arthralgia without arthritis raised inflammatory markers
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how is rheumatic fever managed
treatment of infections with antibiotics helps prevent rheumatic fever - Phenoxymethylpenicillin (V) for 10 days patients with rheumatic fever - MDT - NSAIDS - Aspirin and steroids to treat carditis - prophylactic antibiotics to prevent further infections and recurrence of rheumatic fever - monitoring and management of complications
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what are the complications of rheumatic fever
recurrence valvular heart disease (mitral stenosis) chronic heart failure
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what is eczema
chronic atopic condition caused by defects in the normal continuity of the skin barrier leading to inflammation in the skin
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when does eczema usually present
presents in infancy with dry, itchy and sore patches of skin over the flexor surfaces and on the face and neck
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what is the pathophysiology of eczema
eczema is caused by defects in the barrier that the skin provides. Gaps in the skin barrier provide and entrance for irritants, microbes and allergens that create an immune response, resulting in inflammation and the associated symptoms
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what are different types of eczema
atopic dermatitis contact dermatitis dyshidrotic eczema neurodermatitis nummular eczema seborrheic dermatitis
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what are symptoms of eczema
dry skin itchy skin skin rash bumps on your skin thick, leathery patches of skin flaky, scaly or crusty skin swelling
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where are common places eczema presents
hands neck elbows ankles knees feet face, especially cheeks in and around the ears lips
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what is the management of eczema
maintenance and management of flairs
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what is done for maintenance in eczema treatment
create an artificial barrier over the skin - done using emollients that are thick and greasy patients should avoid activities that can break down the skin barrier - bathing in hot water, scratching or scrubbing their skin, using soaps and body washes that remove natural oils
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how are flairs treated in eczema
thicker emollients, topical steroids, wet wraps (covering affected areas in a thick emollient and applying a wrap to keep moisture in) treating complications such as bacterial or viral infections
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what specialist treatments are used in severe eczema
zinc impregnated bandages topical tacrolimus phototherapy systemic immunosuppressants such as oral corticosteroids, methotrexate and azathioprine
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what are examples of thin emollient creams
E45 diprobase cream oilatum cream aveeno cream cetraben cream epaderm cream
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what are examples of thick, greasy emollient creams used in eczema
50:50 ointment (5% liquid paraffin) hydromol ointment diprobase ointment cetraben ointment epaderm ointment
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what is the theory for using topical steroids for eczema
general rule is to use the weakest steroid for the shortest period of time to get the skin under control - thicker the skin the stronger the steroid required
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what are side effects that can happen with use of steroids in eczema
can lead to thinning of the skin makes the skin more prone to flares, bruising, tearing, stretch marks and enlarged blood vessels (telangiectasia)
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what is the steroid ladder used in eczema from least to most strong
Mild: hydrocortisone 0.5, 1 and 2.5 % moderate: Eumovate (clobetasone butyrate 0.05%) potent: Betnovate (betamethasone 0.1%) very potent: Dermovate (clobetasol propionate 0.05%)
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what is the most common bacterial infection that can occur in eczema
most common is staph. aureus
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how is bacterial infection treated in eczema
oral antibiotics - flucloxacillin more severe cases may need admission and IV antibiotics
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what is eczema herpeticum
this is a viral skin infection in patients with eczema caused by HSV or VZV
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what is the most common causative organism in eczema herpeticum
Herpes simplex virus 1 may be associated with a coldsore
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how does eczema herpeticum present
patient that suffers with eczema that has developed a widespread, painful, vesicular rash systemic symptoms such as fever, lethargy, irritability, and reduced oral intake there will usually be lymphadenopathy
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what does the rash look like in eczema herpeticum
widespread - can affect any area of the body erythematous painful can be itchy vesicles containing pus which burst and leave small punched out ulcers with a red base
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what is the management of eczema herpeticum
viral swabs can confirm the diagnosis treatment is with aciclovir - in milder cases use oral and in severe cases use IV
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what are complications of eczema herpeticum
life threatening when not treated correctly, particularly in those immunocompromised bacterial superinfection can occur
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what is stephens johnson syndrome
disproportional immune response causes epidermal necrosis, resulting in blistering and shedding of the top layer of the skin
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what is the difference between stevens-johnson syndrome and toxic epidermal necrolysis
they are a spectrum of the same pathology SJS affects less than 10% of the body surface TEN affects more than 10% of the body surface
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what are causes of stephen-johnson syndrome
medications: anti-epileptics, antibiotics, allopurinol, NSAIDS infections: herpes simplex, mycoplasma pneumonia, cytomegalovirus, HIV
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how does stephen-johnson syndrome present
dependent on severity starts nonspecific such as fever, cough, sore throat, sore mouth, sore eyes, itchy skin then develop a purple or red rash that spreads across the skin and starts to blister few days after blistering starts the skin starts to break away and shed eyes can become inflamed and ulcerated can affect urinary tract, lungs and internal organs
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what is the management of stephen-johnson syndrome
medical emergency nutritional care, antiseptics, analgesia steroids immunoglobulins immunosuppressants
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what are complications of stephen-johnson syndrome
secondary infection: breaks in skin can lead to bacterial infection, cellulitis and sepsis permanent skin damage visual complications: sore eyes, scarring or blindness
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what is urticaria
also known as hives - small itchy lumps that appear on the skin can be localised or widespread
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what are the two types of uritcaria
acute chronic
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what is the pathophysiology of urticaria
urticaria is caused by release of histamine and other pro-inflammatory chemicals by mast cells in the skin - can be part of an allergic reaction in acute - can be due to autoimmune reaction in chronic
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what are causes of acute urticaria
allergies to food, medications or animals contact with chemicals, latex or stinging nettles medications viral infections insect bites dermatographism (rubbing of skin)
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what causes chronic urticaria
autoimmune condition where autoantibodies target mast cells, and can be sub-classified into: chronic idiopathic chronic inducible autoimmune
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what is chronic idiopathic urticaria
it is recurrent episodes of chronic urticaria without a clear underlying cause or trigger
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what is chronic inducible urticaria
episodes of urticaria that can be induced by certain triggers such as: sunlight temperature change exercise strong emotions hot or cold weather pressure (dermatographism)
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what is autoimmune urticaria
it is chronic urticaria which is associated with an underlying autoimmune condition such as SLE
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what is the management of urticaria
antihistamines are the main treatment - fexofenadine oral steroids can be used in severe flares in very problematic cases referral is needed and specialised treatment may be given: anti-leukotrienes (montelukast) ,omalizumab and cyclosporin
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what are birthmarks
they are marks on the skin that are present at birth or can show up soon after, which cosmetically change the appearance of the skin
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what are the types of birthmarks
vascular birthmarks: made of blood vessels pigmented birthmarks: cluster of melanocyte cells
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what are types of vascular birthmarks
hemangiomas port wine stains salmon patches/stork bites
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what is a strawberry hemangioma
they consist of small closely packed blood vessels which develop after several weeks and are often rapidly growing
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where might hemangiomas commonly present
face, scalp. back or chest
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what is a cavernous hemangioma
it is similar to a strawberry hemangioma but extends deeper below the surface of the skin
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what are port wide stain birthmarks
flat, purple to red birthmarks made of dilated blood capillaries, which most often appear on the face port wine stains are permanent and may darken over time
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what are salmon patches/stork bite birthmarks
these marks are capillaries which are visible through the childs skin they are most common on the forehead, eyelids, upper lip, between the eyebrows and back of the neck
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what are the different types of pigmented birthmarks
dermal melanocytosis (mongolian spots) pigmented nevi congenital nevi cafe-au-lait spots
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what are the dermal melanocytosis birthmark
this is a bluish birthmark which can look like a bruise they often appear on the buttocks and the lower back
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what are pigmented nevi
these are raised growths on the skin that are the same colour as you natural skin tone/brown/black moles can appear anywhere on the skin
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what are congenital nevi
these are moles which are present at birth and have a slightly higher chance of becoming skin cancer, depending on the size
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what are cafe-au-lait spots
they are light tan or light brown spots that are usually oval in shape they appear at birth but bight develop in the first few years of a childs life multiple spots might be a sign of an underlying condition called neurofibromatosis
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what causes birthmarks
blood vessels not forming as expected melanocyte cells growing in clusters genetic predisposition underlying medical condition
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how are birthmarks diagnosed
physical examination if its deep in the skin may image it - MRI, ultrasound or CT skin biopsy may be necessary
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what are the treatment options for removing a birthmark
cryotherapy laser removal surgical removal injections of cortisone
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what is psoriasis
it is a chronic autoimmune condition that causes recurrent symptoms of psoriatic skin lesions
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what are symptoms of psoriasis
patches of psoriasis are dry, flaky, scaly and faintly erythematous skin lesions can appear in raised and rough plaques commonly over extensor surfaces of the elbows, knees and scalp
275
what are types of psoriasis
plaque psoriasis guttate psoriasis pustular psoriasis erythematous psoriasis
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what are features of plaque psoriasis
thickened erythematous plaques with silver scales, commonly seen on the extensor surfaces and scalp plaques are 1cm-10cm most common in adults
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what are features of guttate psoriasis
it is the second most common commonly occurs in children presents with small raised papules across he trunk and limb mildly erythematous scaly over time the papules can become plaques
278
what are causes of guttate psoriasis
streptococcal throat infection stress medications
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what are features of pustular psoriasis
severe form where pustules form around areas of erythematous skin patients can be systemically unwell treated as medical emergency
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what are the features of erythrodermic psoriasis
rare severe form extensive erythematous inflamed areas covering most of the surface area of the skin skin comes away in large patches medical emergency
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how does psoriasis present
in children the distribution and presentation may differ than in adults plaques are likely to be smaller, soften and less prominent
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what are signs which are suggestive of psoriasis
Auspitz sign: small points of bleeding where plaques are scraped off Koebner phenomenon: development of psoriatic lesions to areas of skin affected by trauma residual pigmentation of skin after lesions resolve
283
what is the management of psoriasis
topical steroids topical vitamin D analogues (calcipotriol) topical dithranol topical calcineurin inhibitors (tacrolimus) are usually only used in adults phototherapy with narrow band UV B light in extensive guttate psoriasis where topical treatments fail children may be started on unlicensed systemic treatment under specialist guidance: methotrexate, cyclosporin, retinoids, biologics
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what are two products containing steroid and vitamin D that care used in psoriasis
Dovobet Enstilar These not licensed in children and will be guided by a specialist.
285
what are other conditions that are associated with psoriasis
nail psoriasis: nail pitting, thickening, discolouration, ridging and onycholysis psoriatic arthritis psychosocial issues obesity, hyperlipidaemia, hypertension, T2DM
286
what causes acne valgaris
caused by chronic inflammation with or without localised infection, in pockets within the skin known as pilosebaceous unit. Acne results from increased production of sebum, trapping of keratin and blockage of the pilosebaceous unit leading to swelling and inflammation
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what are the pilosebaceous units
these are tiny dimples in the skin that contain the hair follicles and sebaceous glands. The sebaceous glands produce the natural skin oils and a waxy substance known as sebum
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why is acne exacerbated by puberty
because androgenic hormones increased the production of sebum
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what are comedones
these are swollen and inflamed units in acne
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how does acne vulgaris present
red, inflamed and sore spots on the skin, typically distributed across the face, upper chest and back has macules, papules and pustules comedomes - skin coloured papules blackheads ice pick scars - small indentations in the skin that remain after acne lesions heal hypertrophic scars - small lumps in the skin that remain after acne lesions heal rolling scars - irregular wave like irregularities of the skin that remain after acne lesions heal
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how is acne managed
reduce symptoms of acne, reduce risk of scarring - topical benzoly peroxide: reduces inflammation and helps unblock skin, toxic to P.acnes bacteria - topical retinoids: slow production of sebum - topical antibiotics such as clindamycin - oral antibiotics such as lymecycline - oral contraceptive pill
292
what is used as an effective last line treatment for acne
oral retinoids - need careful follow up and monitoring and reliable contraception in females
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what COCP is the most effective for acne
Co-cyprindiol (dianette) - it has higher risk of thromboembolism so treatment is usually discontinued once acne is controlled and is not prescribed long term
294
what is isotretinoin
it is a retinoid which is very effective at clearing the skin
295
what is the mode of action of isotretinoin
it reduces the production of sebum reduces inflammation reduces bacterial growth
296
what are side effects of isotretinoin
dry skin and lips photosensitivity of the skin to sunlight depression, anxiety, aggression and suicidal ideation - screen for mental health issues prior rarely stephens-johnson syndrome and toxic epidermal necrolysis
297
what are the six viral exanthemas diseases
first disease: measles second disease: scarlet fever third disease: Rubella fourth disease: Dukes' disease fifth disease: Parvovirus B19 sixth disease: roseola infantum
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what causes measles
measles virus
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when do measles symptoms start after exposure
10-12 days after exposure
300
what are koplik spots
these are greyish white spots on the buccal mucosa, and appear 2 days after fever in measles
301
where does the rash start in measles
the rash starts on the face, classically behind the ears 3-5 days after the fever it then spreads to the rest of the body
302
how long does measles last
it is self resolving after 7-10 days of symptoms
303
how long should children with measles isolate for
children should be isolated until 4 days after their symptoms resolve
304
what are complications of measles
pneumonia diarrhoea dehydration encephalitis meningitis hearing loss vision loss death
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what bacteria is scarlet fever often associated with
group A streptococcus infection, usually tonsilitis
306
what causes scarlet fever
it is caused by an exotoxin produced by the streptococcus pyogenes bacteria
307
what is the characteristic rash in scarlet fever
red-pink, blotchy macular rash with rough sandpaper skin starts on the trunk and spreads outward
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what are features of scarlet fever
rash flushed red cheeks fever lethargy sore throat strawberry tongue cervical lymphadenopathy
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what is the treatment for scarlet fever
phenoxymethylpenicillin for 10 days
310
how long should children with scarlet fever be off school for
until 24 hours after starting antibiotics
311
what causes rubella
the rubella virus
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how soon after infection so rubella symptoms start
2 weeks after exposure
313
what are the symptoms of rubella
milder erythematous rash than measles rash starts on face and spreads to the rest of the body, lasting 3 days mild fever joint pain sore throat lymphadenopathy behind ears and back of neck
314
how long should children stay off school with rubella
for at least 5 days after the rash appears
315
what are the complications of rubella
thrombocytopenia encephalitis in pregnancy can be dangerous and lead to congenital rubella which causes deafness, blindness and congenital heart disease
316
what causes slapped cheek syndrome
parvovirus B 19
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what is the disease course of slapped cheek syndrome
starts with mild fever, coryza and non specific viral symptoms then 2-5 days in a rash appears as a diffuse bright red rash on both cheeks few days later a mildly erythematous lace like rash appears on the trunk and limbs
318
how long do children with slapped cheek syndrome need to stay off school for
infectious prior to the rash forming but once the rash has formed they are no longer infectious and dont need to stay off school
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what patients are at risk of complications when infected with parvovirus B19
immunocompromised pregnant patients sickle cell anaemia thalassemia hereditary spherocytosis haemolytic anaemia
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what are the complications of parvovirus B19
aplastic anaemia encephalitis or meningitis pregnancy complications including fetal death rarely hepatitis, myocarditis or nephritis
321
what causes roseola infantum
HHV 6 and less frequently HHV7
322
what is the pattern of illness with roseola infantum
presents 1-2 weeks after infection with a high fever (up to 40o) lasting 3-5 days coryzal symptoms when the fever settles the rash appears for 1-2 days consisting of a mild erythematous rash across the arms, legs, trunk and face. It is not itchy
323
what is the min complication of roseola infantum
febrile convulsions
324
what is parvovirus B19 infection known as
slapped cheek syndrome or erythema infectiosum
325
what is erythema multiforme
it is a erythematous rash caused by a hypersensitivity reaction
326
what are the most common causes of erythema multiform
viral infections and medications associated with herpes simplex virus and mycoplasma pneumonia
327
how does erythema multiform present
it produces a widespread, itchy, erythematous rash produces characteristic target lesions - red rings within larger rings doesnt usually affect mucous membraned but can cause a sore mouth may be associated with mild fever, stomatitis, muscle and joint aches, headaches and flu like illness
328
what is the management of erythema multiforme
need to identify the underlying cause and treat that when there is no clear cause - chest x ray (look for cause) usually it is mild and will resolve spontaneously without further treatment in severe cases it may need hospital admission for treatment with IV fluids, analgesia, steroids
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what causes chicken pox
Varicella zoster virus
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how does chickenpox present
widespread, erythematous, raised, vesicular blistering lesions rash normally starts on the face or trunk and spreads outward affecting the whole body over 2-5 days eventually lesions scab over
331
what is often the first symptom of chicken pox
fever
332
when does a patient with chicken pox stop being infectious
after all the lesions have crusted over
333
what are complications of chickenpox
bacterial superinfection dehydration conjunctival lesions pneumonia encephalitis
334
what can happen if chickenpox is caught during pregnancy
if the woman is not immune, and catches it before 28 weeks it can cause developmental issues in the fetus chickenpox around the time of delivery can lead to life threatening neonatal infection treated with VZ immunoglobulins and aciclovir
335
what is the management of chickenpox
normally self limiting aciclovir can be used in immunocompromised patients, adults and adolescents over 14 presenting within 24 hours, neonates and those at risk of complications symptoms of itching can be treated with calcamine lotion and chlorphenamine (antihistamine)
336
what is the cause of hand foot and mouth disease
coxsackie A virus
337
how does hand foot and mouth present
illness typically starts with viral respiratory tract symptoms after 1-2 days small mouth ulcers appear followed by blistering red spots across the body, notably on the hands, feet and mouth painful mouth ulcers on tongue are also present
338
what is the management of hand foot and mouth
no treatment - management is supportive with adequate fluid intake and simple analgesia such as paracetamol if required the rash and illness resolve spontaneously without treatment after a week to 10 days
339
what are complications of hand, foot and mouth
dehydration bacterial superinfection encephalitis
340
what advice should be given to help the spread of hand foot and mouth
as its highly contagious advise should be given such as: avoiding sharing towels and bedding washing hands careful handling dirty nappies
341
what is molluscum contagiosum
it is a viral skin infection caused by the molluscum contagiosum virus which it a type of poxvirus
342
what are features of molluscum contagiosum
small flesh coloured papules that characteristically have a central dimple they typically appear in crops of multiple lesions in a local area it spreads through direct contact or by sharing items like towels or bedsheets
343
how do the papules in molluscum contagiosum resolve
by themselves without treatment however this can take up to 18 months
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what is the management for molluscum contagiosum
no treatment or change in lifestyle is required avoid sharing towels or other close contact with lesions to minimise the risk of spreading rarely bacterial superinfection occurs in the lesions due to scratching and this may need antibiotics such as fuscidic acid or flucloxacillin
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in an immunocompromised patient with molluscum contagiosum what treatment options may be given
topical potassium hydroxide, benozyl peroxide, podophyllotoxin imiquimod or tretinoin surgical removal and cryotherapy
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what is pityriasis rosea
it is a generalised self limiting rash that has an unknown cause. it may be caused by a virus such as HHV6 or 7 but no definitive cause has been established
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how does pityriasis rosea present
there may be prodromal symptoms prior to the rash such as headache tiredness, LOA and flu like symptoms the rash then starts with a herald patch (faint red or pink scaly oval lesion 2cm or more) which normally presents on the torso then the rash appears which is a widespread faint red/pink slightly scaly oval shaped lesions. seen as christmas tree rash on the torso may have a generalised itch, pyrexia, headache and lethargy
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what is the disease course of pityriasis rosea
resolves without treatment within 3 months can leave a discolouration of the skin where the lesions were but this will resolve within another few months
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what is the management for pityriasis rosea
no treatment for the rash patient education and reassurance can have symptomatic treatment if bothered by itching such as emollients, topical steroids or sedating antihistamines at night (chlorphenamine)
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what is seborrhoeic dermatitis
this is an inflammatory skin condition that affects the sebaceous glands, affecting skin where there are a lot of these glands such as the scalp, nasolabial folds and the eyebrows
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how does seborrhoeic dermatitis present
erythema dermatitis crusted dry skin in infants it causes a crusted cry flaky scalp often called cradle cap
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what is thought to be the cause of seborrhoeic dermatitis
Malassezia yeast colonisation is thought to have a role and the condition improves with antifungal treatment
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what is infantile seborrhoeic dermatitis
it is a self limiting condition which causes a crusted flaky scalp
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what is the first line treatment for infantile seborrhoeic dermatitis
applying baby oil, vegetable oil or olive oil, and gently brushing the scalp and then washing off when this isnt effective white petroleum jelly can be used overnight to soften crusted areas
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how is infantile seborrhoeic dermatitis treated if oil/emollients are not working
topical anti-fungal cream such as clotrimazole or miconazole used for up to 4 weeks
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what is seborrhoeic dermatitis of the scalp
this is a condition which presents with faky itchy skin on the scalp, with more severe cases causing more dense oily scaly brown crusting - commonly in adolescents and adults rather than children
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what is the first line treatment forseborrhoeic dermatitis of the scalp
ketoconazole shampoo, left on for 5 minutes before washing off topical steroids may be sued if there is severe itching
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what is seborrhoeic dermatitis of the face and body
this is a condition which presents with red, flaky, crusted itching skin, commonly affecting the eyelids, nasolabial folds, ears, upper chest and back
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what is the treatment for seborrhoeic dermatitis of the face and body
anti-fungal cream such as clotrimazole or miconazole used for up to 4 weeks localised areas may benefit from topical steroids such as hydrocortisone 1%
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what is ringworm
this is a fungal infection of the skin also known as tinea and dermatophytosis
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what are the specific names of fungal infections depending on the areas they infect
tinea capitis - ringworm affecting the scalp tinea pedis - ringworm affecting the feet tinea cruris - ringworm of the groin tinea corporis - ringworm on the body onychomycosis - fungal nail infection
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how does ringworm present
itchy rash that is erythematous, scaly and well demarcated often one or several rings or circular shaped areas that spread outward, with a well demarcated edge edge is more prominent and red
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how does tinea capitis present
normal ringworm presentation plus well demarcated hair less also be itching, dryness and erythema of the scalp
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how does tinea pedis present
white or red flaky, cracked, itchy patches between the toes skin may split and bleed
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how does onychomycosis present
thickened, discoloured and deformed nails
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what is the management for ringworm
antifungal medications - creams: clotrimazole or miconazole - shampoo: ketoconazole - oral medications: fluconazole, griseofulvin and itraconazole
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how are fungal nail infections treated
with amoroline nail lacquer for 6 -12 months Resistant cases may need oral terbinafine, however the patient will need their LFTs monitoring before and whilst taking this.
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what can help with the inflammation and itching in ringworm
mild topical steroids: hydrocortisone 1% (often combined with miconazole 2%)
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what simple advice can be given to people with ringworm to help recovery, prevent spread and avoid recurrence
Wear loose breathable clothing Keep the affected area clean and dry Avoid sharing towels, clothes and bedding Use a separate towel for the feet with tinea pedis Avoid scratching and spreading to other areas Wear clean dry socks every day
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what is tinea incognito
it is a more extensive and less well recognised fungal skin infection that results from the use of steroids to treat an initial fungal infection This often occurs when the initial presentation of ringworm was misdiagnosed as dermatitis and a topical steroid was prescribed. The steroid improves the itching and inflammation but accelerates the growth of the fungal infection by dampening the immune response in the local area
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what is the presentation of tinea incognito
less recognisable as ringworm as there is a less demarcated boarder and fewer scales
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what is nappy rash
it is a contact dermatitis in the nappy area usually caused by friction between the skin and the nappy and contact with urine and faeces in a dirty nappy
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what are risk factors for nappy rash
delayed changing of nappies irritant soap products and vigorous cleaning certain types of nappies (poorly absorbent ones) diarrhoea oral antibiotics predispose to candida infection pre-term infants
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how does nappy rash present
sore, red, inflamed skin in the nappy area rash appears in individual patches on exposure areas of the skin tends to spare the skin creases skin may be uncomfortable, itchy and infant may be in distress longstanding rash may lead to erosions and ulceration
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how can you tell the difference between nappy rash and candidal infection
candida (thrush) in the nappy area is a common finding, signs that would point to candida rather than nappy rash are: - rash extending into the skin folds - larger red macules - well demarcated scaly border - circular pattern to the rash spreading outward - satellite lesions which are smaller patches of rash or pustules near to the main rash - may have oral thrush as well
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what is the management of nappy rash
simple measures to improve skin health: Switching to highly absorbent nappies (disposable gel matrix nappies) Change the nappy and clean the skin as soon as possible after wetting or soiling Use water or gentle alcohol free products for cleaning the nappy area Ensure the nappy area is dry before replacing the nappy Maximise time not wearing a nappy infection with candida or bacteria warrants treatment with antifungal or antibiotic (fusidic acid cream or flucloxacillin)
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what are complications of nappy rash
Candida infection Cellulitis Jacquet’s erosive diaper dermatitis Perianal pseudoverrucous papules and nodules
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what is scabies
scabies is tiny mites called sarcoptes scabiei that burrow under the skin causing infection and intense itching. They lay eggs in the skin, leading to further infection and symptoms
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how does scabies present
can take up to 8 weeks for any symptoms to appear after the initial infection incredibly itchy small red spots, possibly with track marks where the mites have burrows classic location of the rash is between the finger webs but can spread to the whole body
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what is the management of scabies
permethrin cream - applied to the shole body, completely covering the skin. the cream should be left on for 8-12 hours and then washed off. this should be repeated a week later to catch all the eggs that survived the first treatment and have now hatched oral ivermectin as a sngle dose can be repeated a week later for difficult to treat/crusted scabies
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what advice should be given to people diagnosed with scabies
All clothes, bedclothes, towels and other materials in contact with scabies need to be washed on a hot wash to destroy the mites. Thorough hoovering of carpets and furniture is also essential.
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what can be given to people with scabies to help with the itching
Crotamiton cream and chlorphenamine at night
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what is crusted scabies
it is a serious infestation with scabies in patients that are immunocompromised it is extremely contagious rather than individual spots and burrows they have patches of red skin that turn into scaly plaques
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what are headlice
they are the pediculus humanus capitis parasite which causes infestations of the scalp
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how are headlice transmitted
head to head contact or by sharing equipment like combs or towels
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how does head lice present
itchy scalp can see visible eggs and lice on examination
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what is the management for head lice
dimeticone 4% applied to hair and left to dry - left on for 8 hrs and then washed off. this is then repeated 7 days later to catch any like that have hatched since the treatment fine combs can be used
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what are non blanching rashes
these are rashes caused by bleeding under the skin, and can be described as petechiae (<3mm) and purpura (3-10mm)
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what are causes of a non blanching rash
meningococcal septicaemia or other bacterial sepsis Henoch-schonlein purpura idiopathic thrombocytopenic purpura acute leukaemias haemolytic uraemic syndrome mechanical: strong coughing, vomiting or breath holding traumatic: non accidental injury, occlusion of blood in an area viral illness: influenza and enterovirus
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what investigations should be done if a child presents with a non blanching rash
FBC, U+E, CRP, ESR coagulation screen blood culture meningococcal PCR lumbar puncture blood pressure urine dipstick
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what is erythema nodosum
this is a condition where red lumps appear across the patients shins, caused by inflammation of the subcutaneous fat on the shins
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what causes erythema nodosum
a hypersensitivity reaction and is associated with a number of triggers and underlying conditions
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what are trigger that can cause erythema nodosum
streptococcal throat infections gastroenteritis mycoplasma pneumoniae tuberculosis pregnancy medications such as the OCP and NSAIDS
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what chronic diseases is erythema nodosum associated with
inflammatory bowel disease sarcoidosis lymphoma leukaemia
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how does erythema nodosum present
red, inflamed, subcutaneous nodules across both shins nodules are raised and can be painful and tender often will settle over time and appear as bruises
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what investigations should be done in someone with erythema nodosum
diagnosis is based on clinical presentation Inflammatory markers (CRP and ESR) Throat swab for streptococcal infection Chest xray can help identify mycoplasma, tuberculosis, sarcoidosis and lymphoma Stool microscopy and culture for campylobacter and salmonella Faecal calprotectin for inflammatory bowel disease
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how is erythema nodosum managed
conservatively with rest and analgesia steroids can be used to settle the inflammation
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what is impetigo
it is a superficial bacterial infection usually caused by staphylococcus aureus bacteria (can also be caused by streptococcus pyogenes)
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how does impetigo occur
when bacteria enters via a break in the skin - healthy skin or can be related to eczema or dermatitis
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what is non bullous impetigo
typically occurs around the nose and mouth, and has exudate from lesions that dries to form a golden crust
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how is non bullous impetigo treated
topical fusidic acid can be used antiseptic cream (hydrogen peroxide 1%) can be used in localised non bullous impetigo oral flucloxacillin can be used in more widespread or severe impetigo
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what advice should be given about how to reduce spread of impetigo
Patients should be given advice about not touching or scratching the lesions, hand hygiene and avoiding sharing face towels and cutlery. They need to be off school until all the lesions have healed or they have been treated with antibiotics for at least 48 hours.
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what is bullous impetigo
it is aways caused by staphylococcus aureus bacteria, and causes 1-2cm fluid filled vesicles to form on the skin which grow and then burst causing a golden crust
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what type of impetigo is more common in neonates and children under 2
bullous impetigo
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what are symptoms of bullous impetigo
lesions - golden crust, painful, itchy feverish malaise can cause staphylococcus scalded skin syndrome
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what is the treatment of bullous impetigo
antibiotics - flucloxacillin
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what are complications of impetigo
Cellulitis if the infection gets deeper in the skin Sepsis Scarring Post streptococcal glomerulonephritis Staphylococcus scalded skin syndrome Scarlet fever
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what is staphylococcus scalded skin syndrome
this is a condition caused by a type of staphylococcus aureus bacteria that produces epidermolysis toxins. These break down proteins that holds skin together
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how does scalded skin syndrome present
generalised patches of erythema on the skin then the skin looks thin and wrinkles then there is formation of bullae which burst and leave very sore erythematous skin below gentle rubbing of the skin causes it to peel away will have generalised symptoms: fever, irritability, lethargy, dehydration
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what is Nickolsky sign
where very gentle rubbing of the skin causes it to peel away. This is positive in SSSS.
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what is the management of scalded skin syndrome
IV antibiotics fluid and electrolyte balance is key
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what is pityriasis versicolour
it is a yeast infection of the skin which causes flaky discoloured patches on the chest and back
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who are most likely to get pityriasis versicolour
commonly affects young adults slightly more common in men than women can also affect children, adolescents and older adults
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what are risk factors for pityriasis versicolour
it is more common in hot humid climates it affects those who heavily perspire may be clear in winter months and recur in the summer
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what causes pityriasis versicolour
fungi in the genus Malassezia which are a part of the normal microbiota most common are M. globosa, M. restricta and M. sympodialis
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how do Malassezia cause pityriasis
One theory implicates a tryptophan-dependent metabolic pathway. The yeasts induce enlarged melanosomes (pigment granules) within basal melanocytes in the brown type of pityriasis versicolor. The white or hypopigmented type of pityriasis versicolor is thought to be due to a chemical produced by malassezia that diffuses into the epidermis and impairs the function of the melanocytes. The pink type of pityriasis versicolor is mildly inflamed, due to dermatiits induced by malassezia or its metabolites.
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what are the clinical features of pityriasis versicolour
affects the neck, trunk and/or arms patches may be coppery brown, paler than surrounding skin or pink pale patches are more common in darker skin normally asymptomatic but may have mild itching
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how is Pityriasis versicolour diagnosed
wood lamp (black light) examination - yellow-green fluorescence may be seen dermoscopy of the patches - pallor, background faint pigment network and scale microscopy of skin scraping fungal culture skin biopsy
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what is the treatment of pityriasis versicolour
mild - topical antifungals: selenium sulfide shampoo, topical azole cream/shampoo, terbinafine gel applied to skin for 5-15 minutes and then washed off - daily for for one week and then weekly for one month systemic measures - oral: fluconazole prevention - selenium sulfide shampoo every month once the rash has cleared
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what is rosacea
it is a long term skin condition that mainly affects the face - redness
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what are the symptoms of rosacea
redness across the nose, cheeks, forehead, chin, neck and chest that comes and goes usually lasts minutes each time face may also feel warm, hot and painful burning or stinging feeling when using water or skincare products may cause tiny broken blood vessels on face dry skin and swelling around the eyes yellow-orange patches on the skin sore eyelids or crusts around the roots of the eyelashes thickened skin mainly around the nose
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what are triggers for rosacea
It's not known what causes rosacea, but some things can make symptoms worse. Common triggers for rosacea include: alcohol spicy foods hot drinks sunlight hot or cold temperatures aerobic exercise, like running being stressed
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what is the treatment for rosacea
cant be cured but can control symptoms creams: brimonidine gel to reduce redness, creams such as azelaic acid or metronidazole antibiotics for 6-16 weeks: doxycycline dermatology referral
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what can be done to help with rosacea
wear a high SPF sunscreen of at least SPF 30 every day try to avoid heat, sunlight or humid conditions if possible try to cover your face in cold weather use gentle skincare products for sensitive skin clean your eyelids at least once a day if you have blepharitis take steps to manage stress
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if a child presents with a imp/hip pain and has a fever what is the management
they need to be referred for same day assessment even if transient synovitis is suspected
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