Psychiatry Flashcards
1
Q
Clozapine metabolised by which CYP
A
CYP1A2
2
Q
Effect of smoking on clozapine metabolism
A
Smoking induces CYP1A2, drops levels. Therefore higher levels when stop smoking
3
Q
When does agranulocytosis occur with clozapine Rx?
A
3-6 months in
4
Q
4 features of NMS
A
Fever, rigidity, mental status changes, autonomic instability
5
Q
NMS occurs most common within what time frame
A
Within 7 days, never after 30 days
