Psychiatric genetics

Question 1

inheritance of Huntington’s disease

Answer 1

autosomal dominant

Question 2

genetic defect of huntington’s disease

Answer 2

CAG trinucleotide repeat resulting in polyglutamine with defect of huntington protein

Question 3

what is genetic anticipation and in which condition is it seen

Answer 3

increased severity in future generation seen in huntington’s disease with more CAG repeats

Question 4

when is the onset of huntingtons disease

Answer 4

30-50s

Question 5

what is the most common type of dementia

Answer 5

Alzheimer’s disease

Question 6

what is dementia

Answer 6

progressive decline in global cognitive ability

Question 7

symptoms of Alzheimer’s

Answer 7

short term memory problems 
dysphasia
dyspraxia 
agnosia 
mood symptoms 
lose swallow at end stages

Question 8

pathology of Alzheimer’s disease

Answer 8

accumulation of extracellular B amyloid plaques and intracellular neurofibrillary Tau tangles

Question 9

what is the gene implicated in bipolar disorder

Answer 9

not known yet but all we know is pattern of inheritance is very much like autosomal dominant
therefore multifactorial