PSY349 Final Flashcards
What outcomes are associated with the down-regulation of the endocannabinoid system?
Anxiety, difficulty sleeping, depressed mood, and reduced motivation
What is an important role of endogenous cannabinoids, such as anandamide, in the brain?
They are released to buffer and mitigate the impact of stressful or traumatic experiences.
What did the quantitative meta-analysis on cue reactivity in imaging studies, focusing on nicotine, alcohol, and cocaine users, reveal about the core circuits of drug craving?
Ventral striatum, anterior cingulate, and amygdala were identified as core circuits of drug craving.
What distinguishes voyeuristic disorder according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5)?
Recurrent, intense sexually arousing fantasies, urges, or behaviors involving the observation of an unsuspecting person undressing or engaging in sexual activity
According to Dr. Carnes (1989), what are the characteristics associated with sex addicts?
Severe shame and depression, tendencies towards suicidal thoughts
The association between highly processed foods and “food addiction” is linked to characteristics shared with drugs of abuse, such as _______ and ________.
High dose; rapid absorption
One reason for the resistance to using an addiction framework for compulsive sexual behavior and pornography use is the fear of pathologizing people that have an unhealthy sexual appetite. [True/False]
False
The Kinsey Institute, a premier research institute on human sexuality, reported findings related to high exposure to pornography videos, including:
Lower sexual responsivity with a partner.
Δ⁹-tetrahydrocannabinol has a high affinity for endogenous cannabinoid (CB1) receptors, whereas cannabidiol (CBD) does not. [True/False]
True
Behavioral or process addictions are similar to substance use disorders in the following way/s:
There is a shift in salience attribution.
Withdrawal is experienced.
What characterizes a behavior associated with process addiction?
Repetitive, persistent behaviors with an inability to stop despite negative consequences.
The subjects in the Kinsey study who reported high exposure to pornography videos also indicated:
Increased need for more extreme, specialized, or “kinky” material.
What qualities of modern pornography make it a potential problem for some individuals?
High-quality recordings with constantly improving image quality, affordability, accessibility without restrictions, and an unlimited offering of sexual content, including risky or illegal practices.
According to a research study discussed in classs: Similar to subjects with addictive disorders, obese subjects have lower baseline striatal D2 R density, which is directionally proportional
to BMI. [True/False]
True
Research discussed in class included a study that found, food consumption is associated with DA release in the dorsal striatum in healthy subjects, and the amount of dopamine released is correlated positively with ratings
of food pleasantness. [True/False]
True
Highly processed foods share similar pharmacokinetic properties [True/False]
True
Addiction [definition]
brain disorder is defined as a chronic, relapsing disorder characterized by compulsive drug-seeking and use despite adverse consequences
Why do we call addiction a disease?
treatable
preventable
modifies biology
genetic factors
IRISA
[Imapired Response Inhibition & Salience Attribution]
take drug –> craving –> binge –> withdrawal –> relapse
Cravings are induced by
triggers or stressors
Addiction shows impairment in which six brain networks:
executive
salience
reward
habit
self-directed
memory
In what ways can PFC functioning be a protective or risk factor?
PFC controls attention and decision making – impaired decision making associated with increased likelihood of doing drugs
Individual protective factor
perceiving substance abuse as risky
secure attachment
self-competence
healthy coping skills
Diathesis Stress Model
diathesis + stress = development of SUD
Adverse Childhood Experiences
stressful/traumatic events
early use of alcohol
higher risk of mental illness and substance use as adults
OUD Diagnostic Criteria
2 of 3 symptoms:
loss of control
risky use
social/vocational problems
What are opioids?
chemical compounds that are derived from natural plant matter
Drivers of the Opioids problem
physicians disregarding the issues
readily accessible to the population
Opioid Withdrawal Symptoms
Anxiety
Insomnia
Muscle pain
Dysphoria
Gastrointestinal distress
Three Medication Options for OUD Treatment
agonist (methadone)
partial agonists (suboxone)
antagonist (antagonist)
Agonist [definition]
bind to receptors and produce a biological response
Partial agonist [definition]
bind to receptors but elicit partial functional response, regardless of the amount of drug administered
Antagonist [definition]
binds to receptors but produces no function response, while also preventing an agonist from binging at that receptor site
Effects of Alcohol on the Brain
calming/sedative effects
HPA axis is changed
decrease in top-down inhibition
Gut-Liver-Brain Axis
alcohol kills gut microbiota leads to have impaired cognitive function, mood changes, continued drinking behavior
chronic drinking increases risk of leaky gut
Psychotherapeutic Approaches
motivational interviewing
cognitive behavioral therapy
contingency management
OARS
community support