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FINALS - DERM > psoriasis > Flashcards

psoriasis Flashcards

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Dermatology Board Prep flashcards
1
Q

genes assoc with psoriasis

A

HLA B13, B17, identical twins

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2
Q

cell pathophysiology psoriasis

A

T cells stimulate kertatinocytes proliferation

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3
Q

which T cells in psoriasis

A

Th17, Th1, Th2

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4
Q

chronic plaque psoriasis

A

well demarcated // red plaques with white scale // extensors, sacrum, scalp

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5
Q

flexural psorasis

A

skin is smooth

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6
Q

pustular psoriasis

A

hands and feet

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7
Q

guttate psorasis

A

transient, small tear trop, psoriatic rash on trunk and limbs

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8
Q

what precipitates guttate psoriasis + how long does it lasts

A

strep infection 2-4 weeks prior // lasts 2-3 montgs

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9
Q

mx guttate psoriasis

A

topical psorasis mx // UVB // tonsillectomy

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10
Q

what is koebners phenomenon

A

skin lesions that appear at site of injury

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11
Q

aside from psoriasis when is koebners phenomenon seen

A

vitiligo, warts, lichen planus, lichen slcerosis, molluscum

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12
Q

what is auspitz sign

A

removing a plaque in –> pinpoint bleeding

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13
Q

common nail symptoms psoriasis

A

pitting, oncholysis, subungal hyperketatosis, loss of nail

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14
Q

what type of psoriasis is most assoc with nail chnages

A

psoriatic arthroplasty (80-90%)

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15
Q

exacerbating factors psoriasis

A

trauma, alcohol, meds, withdrawal from steroids

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16
Q

what meds can trigger psoriasis

A

BB, lithium, alcohol, NSAIDS, chloroquine, ACEi, infliximab

17
Q

in psoriatic arthropathy what is the first symptoms

A

unilateral arthritis

18
Q

1st line mx chronic plaque psoriasis

A

potent steroid + Vit D analogue (calcipotriol) once daily at different times for 4 weeks

19
Q

2nd line topical mx chronic plaque psoriasis + when is it offered

A

no improvement 8 weeks –> Vit D analogue twice a day

20
Q

3rd line topical mx chronic plaque psoriasis + when is it offered

A

no improvement 8-12 weeks –> potent steroid BD for 4 weeks OR tar daily OR dithranol

21
Q

phototherapy for chronic plaque psoriasis

A

UVB light, photochemotherapy

22
Q

SE phototherapy

A

ageing, SCC

23
Q

systemic therapy chronic plaque psoriasis

A

1 = methotraxte // others = ciclopsorin, retinoids, infiliximab

24
Q

mx scalp psoriasis

A

potent topical steroids OD 4 weeks (betnovate)

25
Q

mx face, flexure + groin psoriasis

A

mild or moderate steroid BD 2 weeks

26
Q

SE topical steroids

A

atrophy, striae, rebound symptoms

27
Q

how long after a course of topical steroids can another be started

A

4 weeks minimum

28
Q

how long can topical steroids be used

A

mild - 8 weelks // potent = 4

29
Q

how long can Vit D analogues be used

A

long term

30
Q

when is vit D contraindicated

A

pregnancy

31
Q

mechanism vit D

A

decreased cell division –> decreased epirdermal proliferation

32
Q

what is Vit D particularly good at in psoriasis

A

reducing scale (not redness)

33
Q

downsides tar and dithranol

A

tar stains + dithranol smells

34
Q

mechanism dithranol

A

inhibits DNA synthesis

FINALS - DERM (11 decks)

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