Provide a specific example of monoclonal antibody with bi-specific action

Question 1

Monoclonal antibody

Answer 1

Lab made antibodies generated by identical B cells which are clones from a single parent cell.
Produced ex-vivo

Question 2

Bi-specific action

Answer 2

Antibodies engineered to bind to two different epitopes, or antigens at the same time

Question 3

Example of drug

Answer 3

Catumaxomab

Question 4

What disease is drug used for

Answer 4

Catumaxomab is used for the treatment of patients with malignant ascites, which is the build up in spaces within the abdomen.It accelerates the destruction of tumour cells by different cells, has strong communication with immune cells

Question 5

Drug mechanism

Answer 5

Catumaxomab is able to bind to tumour cells, T-cells and accessory cells

Question 6

What problem does it resolve

Answer 6

Catumaxomab is able to destroy epCAM positive tumour cells which can be found in other types of cancers such as breast, colon and prostate cancer, as it is an epithelial cell adhesion molecule and aid the rapid proliferation of tumours with epithelial origin