Discuss the limitation of chimeric antigen receptor therapy

Question 1

CAR-T therapy

Answer 1

A type of immunotherapy used to treat certain types of cancer. It involves genetically modifying a patient’s own T cells to express a chimeric antigen receptor (CAR) on their surface and bind to cancer cells

Question 2

Limited applicability

Answer 2

CAR T-cells are designed to target specific antigens present on cancer cells. The therapy’s success depends on the availability of well-defined tumor antigens.

Question 3

Cytokine Release Syndrome (CRS)

Answer 3

Upon activation, CAR T-cells release a large number of cytokines, leading to systemic inflammatory responses due to excessive T cell activation
Managed by Ab blocking IL-6 receptors

Question 4

Neurological toxicity

Answer 4

Some patients may experience neurotoxicities, including confusion, delirium, and seizures, as a result of CAR T-cell therapy