Proteins Front Page Flashcards
Basic definition of proteins
- Complex macromolecules made up of amino acids held together by peptide bonds
Functions of Proteins
- They have several roles in a biological system
- Chemical messengers
- membrane-bound protein carriers
- free circulating carriers in blood
- enzymes
- external structures
Chemical Messengers
(Protein function)
- circulate and communicate between cells
- Ex. Insulin
Membrane-bound protein carriers
(Protein function)
- Proteins that are embedded in membranes help in cell transport
Free circulating carriers in blood
(Protein function)
- Ex. Blood pressure, proteins like hemoglobin and albumin
Enzymes
(Protein function)
- Biological catalysts of numerous types
- help in cellular reactions
External structures
(Protein function)
- Made up of keratin
- Ex. Hair, feathers, fingernails, horns
Generalized structure of proteins
- Chains of amino acids folded several times, to make up complex structures
How many amino acids are found in the body?
- there are 20 different types found circulating in the body
How many amino acids can be synthesized by the human body?
12
How many amino acids must be taken in the diet?
8
How many different ‘R’ groups are there?
20
Peptide Bonds
- Bonds that form between two adjacent amino acids
- Between carbon and nitrogen
What is on the left side of a dipeptide molecule?
The Amino or ‘N’ terminus
What is on the right side of a dipeptide molecule?
The carboxyl or ‘C’ terminus
What’s the link called that links two amino acids together?
Peptide link
Disulfide Bridges
- Bonds that form between adjacent sulphurs in complex protein molecules
- Factor accounting for protein shape and organization
How do proteins form, step by step
- Several amino acids join together by peptide links
- Polypeptides form from many peptide links
- The polypeptides get folded which makes proteins
What is a polypeptide?
Many peptide links
What is the strongest folds in proteins?
S-S bonds
Note about disulfide bridges
- Disulfide bridges form between adjacent Cysteines within a polypeptide
- therefore allowing strong folds to form, such as what’s found in keratin
What does keratin make up?
- Hair
- Nails
- Horns
- Hooves