PROTEIN METABOLISM Flashcards
protein digestion starts where?
stomach
produced in the pancreas
pancreatic juice
is the breakdown & re-synthesis
of body protein
protein turnover
what amino acid is most important metabolically
glutamate
Escapes in large amounts from dead or dying liver tissue.
Measured in blood samples for diagnostic purposes.
alanine aminotransferase
Also escapes in large amounts from dead or dying heart tissues & enters bloodstream.
Measured in blood for diagnosing myocardial infarction.
aspartate aminotransferase
will reversibly convert
glutamate to α-ketoglutarate
and α-ketoglutarate to glutamate.
Glutamate dehydrogenase
converting glutamate to α-ketoglutarate is an easily shifted equilibrium reaction.
Oxidative deamination
are toxic compounds in urea cycle
Ammonium salts
building up favors the synthesis of excessive amounts of glutamate, decreasing the Krebs cycle intermediate
Ammonium ions
the urea cycle are NH3, CO2 and aspartic acid and ATP.
input
The ___ are urea, ADP and fumaric acid.
outputs
Spiders excrete _______, 5 nitrogen atoms in a small molecule.
guanine
Aquatic species excrete free _____through gills.
ammonia
Terrestrial critters produce ____- very soluble - still needs water for removal via kidneys.
urea
Defective phenylalanine hydroxylase –
phenylalanine accumulates in body.
Phenylalanine is transaminated to phenylpyruvate.
Phenylketonuria
leads to severe mental retardation in infants.
Phenylketonuria (PKU)
a biochemical reaction that involves the
interchange of the amino group of an a-amino acid
transamination reaction
is a biochemical reaction in which an a-amino acid is converted into an a-keto acid
oxidative deamination
reaction
cyclic biochemical pathway in
which urea is produced, for excretion
urea cycle
amino acid that can be
converted into glucose through
gluconeogenesis.
KETOGENIC
are converted into ketone bodies.
glucogenic
s a rare (1:185,000), autosomal recessive disorder in which there is a
partial or complete deficiency in branched-chain α-keto acid dehydrogenase
Maple syrup urine disease (MSUD)
refers to a group of conditions in which a defect in tyrosine metabolism results in a deficiency in the
production of melanin
albinism