Protein application in biomedicine Flashcards
1
Q
What are the roles of protein in biomedicine?
A
Therapeutics
Biomarkers for lab tests
2
Q
Why use proteins rather than drugs?
A
Very specific interactions More natural Lower risk of adverse effects Their functions can't be easily mimicked Novel functions
3
Q
What are the uses of enzymatic proteins?
A
Replace a deficient/abnormal protein
Augment an existing pathway
Provide a novel activity or function
4
Q
What are the uses of proteins with special targeting activity?
A
Inhibit a specific pathogenic protein/pathway
Deliver other compounds
Most based on monoclonal antibodies
5
Q
What are problems associated with therapeutic proteins?
A
Efficacy Safety Immunogenicity Cannot permeate cell membranes Delivery
6
Q
What is a biomarker?
A
A characteristic that is objectively measured and evaluated as an indicator of biological processes
7
Q
What are the functions of biomarkers?
A
Diagnostic
Prognostic
Predictive
