Latency and activation Flashcards
1
Q
What are signal peptides?
A
Most secretory proteins are synthesised with signal peptides at the N-terminus which are removed after sorting by proteolysis
2
Q
What are propeptides?
A
Folded intramolecular chaperones
Assembly of multimers
Latency
Must be removed for activity
3
Q
What is pro-peptide cleavage?
A
Essential for activation
Basic residues
Cleavage by carboxypeptidase
4
Q
What are pro protein convertases?
A
Remove pro-peptides
5
Q
When does cleavage occur at the cell surface?
A
Wound healing
Tissue remodelling
Ovulation
6
Q
What carries out cleavage at the cell surface?
A
Matrix metalloproteinases
7
Q
What do secretases do?
A
Liberate active domains from membrane-bound proteins
