prostate ca

Question 1

prostate cancer OE

Answer 1

firm hard nodular assymetrical prostate

loss of central sulcus

Question 2

first line Ix

Answer 2

multiparametric MRI

Question 3

what happens after MRI

Answer 3

it is reported using 5 point likert scale

score ≥3 - prostate biopsy

Question 4

prostate biopsy - reported using

Answer 4

gleason grading system

6/low risk
7/int risk
8/high risk

Question 5

Mx options - localised prostate cancer (T1/T2)

Answer 5

conservative - monitor and wait
radical prostatectomy
radiotherapy - external beam and brachytherapy

Question 6

when is active monitor and watchful waiting preferred

Answer 6

patients with low grade disease and significant co-morbidities

Question 7

Mx options - localised advanced prostate cancer (T3/T4)

Answer 7

hormonal therapy
radical prostatecomy
radiotherapy

Question 8

complication on prostatectomy

Answer 8

erectile dysfunction

Question 9

what are patients at. risk of following radiotherapy for prostate cancer

Answer 9

bladder, colon and rectal cancer

Question 10

hormonal Mx options

Answer 10

GnRH agonists
bicalumatide
cyproterone acetate
abiraterone
bilateral orchidectomy

Question 11

GnRH agonists e.g. goserelin

Answer 11

lower LH levels by causing over-stimulation

testosterone will rise initially for first few weeks before falling

Question 12

what is initial therapy with GnRH agonist usually covered with

Answer 12

anti-androgen

- to prevent tumour flare

Question 13

tumour flare

Answer 13

stimulation of prostate cancer by initial Rx GnRH agonist

bone pain, bladder obstruction

Question 14

bicalutamide

Answer 14

non-steroidal anti-androgen

blocks the androgen receptor

Question 15

abiraterone

Answer 15

androgen synthesis inhibitor

Question 16

chemotherapy with..

Answer 16

docetaxel